File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Relationship of retinal vascular caliber with optic disc diameter in children

TitleRelationship of retinal vascular caliber with optic disc diameter in children
Authors
Issue Date2007
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2007, v. 48 n. 11, p. 4945-4948 How to Cite?
AbstractPURPOSE. To describe the relationships of retinal vascular caliber to optic disc diameter in children. METHODS. A school-based cross-sectional study of 746 children aged 7 to 9 years who participated in the Singapore Cohort Study of the Risk Factors for Myopia. Digital retinal photographs of both eyes were taken in 2001 and graded for retinal vascular caliber, vertical optic disc diameter, and vertical cup-to-disc ratio (CDR) according to standardized protocols. All measurements in pixels were analyzed after correction of the magnification. RESULTS. In this study population, the mean retinal arteriolar caliber (SD) was 5.95 (0.51) pixels, retinal venular caliber was 8.58 (0.69) pixels, vertical disc diameter was 73.02 (7.48) pixels, and vertical CDR was 0.34 (0.09). In multiple linear regression analysis with adjustment for age, gender, ethnicity, body mass index, and birth weight, arteriolar caliber decreased by 0.011 pixel (P < 0.001) and venular caliber decreased by 0.016 pixel (P < 0.001), for each pixel decrease in vertical optic disc diameter. The associations remained similar and statistically significant with further adjustment for blood pressure. Vertical CDR was not related to retinal vascular caliber. CONCLUSIONS. In this population of generally healthy children, smaller vertical optic disc diameter was associated with narrower retinal arteriolar and venular calibers. The findings of this study, in conjunction with studies in adults, suggest anatomic relationships between the optic disc and retinal vasculature that may provide additional insights into the vascular etiology of glaucomatous and nonarteritic anterior ischemic optic neuropathy. However, because the detected differences in retinal vascular caliber were small, the clinical significance of the study findings remains uncertain. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183537
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorTong, Len_US
dc.contributor.authorTikellis, Gen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:32Z-
dc.date.available2013-05-28T06:14:32Z-
dc.date.issued2007en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2007, v. 48 n. 11, p. 4945-4948en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183537-
dc.description.abstractPURPOSE. To describe the relationships of retinal vascular caliber to optic disc diameter in children. METHODS. A school-based cross-sectional study of 746 children aged 7 to 9 years who participated in the Singapore Cohort Study of the Risk Factors for Myopia. Digital retinal photographs of both eyes were taken in 2001 and graded for retinal vascular caliber, vertical optic disc diameter, and vertical cup-to-disc ratio (CDR) according to standardized protocols. All measurements in pixels were analyzed after correction of the magnification. RESULTS. In this study population, the mean retinal arteriolar caliber (SD) was 5.95 (0.51) pixels, retinal venular caliber was 8.58 (0.69) pixels, vertical disc diameter was 73.02 (7.48) pixels, and vertical CDR was 0.34 (0.09). In multiple linear regression analysis with adjustment for age, gender, ethnicity, body mass index, and birth weight, arteriolar caliber decreased by 0.011 pixel (P < 0.001) and venular caliber decreased by 0.016 pixel (P < 0.001), for each pixel decrease in vertical optic disc diameter. The associations remained similar and statistically significant with further adjustment for blood pressure. Vertical CDR was not related to retinal vascular caliber. CONCLUSIONS. In this population of generally healthy children, smaller vertical optic disc diameter was associated with narrower retinal arteriolar and venular calibers. The findings of this study, in conjunction with studies in adults, suggest anatomic relationships between the optic disc and retinal vasculature that may provide additional insights into the vascular etiology of glaucomatous and nonarteritic anterior ischemic optic neuropathy. However, because the detected differences in retinal vascular caliber were small, the clinical significance of the study findings remains uncertain. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshArterioles - Pathologyen_US
dc.subject.meshBody Constitutionen_US
dc.subject.meshBody Weights And Measuresen_US
dc.subject.meshChilden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshOptic Disk - Blood Supply - Pathologyen_US
dc.subject.meshPhotographyen_US
dc.subject.meshRetinal Artery - Pathologyen_US
dc.subject.meshRetinal Vein - Pathologyen_US
dc.subject.meshVenules - Pathologyen_US
dc.titleRelationship of retinal vascular caliber with optic disc diameter in childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.07-0472en_US
dc.identifier.pmid17962443-
dc.identifier.scopuseid_2-s2.0-38449113378en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38449113378&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue11en_US
dc.identifier.spage4945en_US
dc.identifier.epage4948en_US
dc.identifier.isiWOS:000250734800014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridTong, L=7201891601en_US
dc.identifier.scopusauthoridTikellis, G=6602765289en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats