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Article: Arterial compliance and retinal vascular caliber in cerebrovascular disease

TitleArterial compliance and retinal vascular caliber in cerebrovascular disease
Authors
Issue Date2007
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645
Citation
Annals Of Neurology, 2007, v. 62 n. 6, p. 618-624 How to Cite?
AbstractObjective: Arterial stiffness is a newly recognized risk factor for stroke. Whether this is mediated by small- or large-artery disease is unknown. In this study, we examined the relationship between arterial stiffness and retinal vascular caliber. Methods: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). Retinal arteriolar and venular calibers were measured from retinal photographs according to standardized protocols. Small- and large-artery compliance was determined from pulse contour analysis. Results: After adjusting for age, sex, blood pressure, diabetes, smoking, lipid profile, and other risk factors, reduced large-artery compliance was associated with smaller retinal arteriolar caliber; each standard deviation decrease in large-artery compliance was associated with a 0.70μm (p = 0.002) decrease in retinal arteriolar caliber. After adjusting for the same set of risk factors, reduced small-artery compliance was associated with wider retinal venular caliber; each standard deviation decrease in small artery compliance was associated with a 1.43μm (p = 0.001) increase in retinal venular caliber. These associations remained significant after further adjustments for large-vessel atherosclerosis (carotid intima-media thickness, coronary artery calcium, and ankle-arm index). Interpretation: Reduced arterial wall compliance in large arterial beds is associated with retinal arteriolar narrowing, whereas reduced arterial wall compliance in small arterial beds is associated with retinal venular widening. These data may provide further insights into the effects of altered arterial stiffness on the cerebral microcirculation. © 2007 American Neurological Association Published by Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183536
ISSN
2015 Impact Factor: 9.638
2015 SCImago Journal Rankings: 5.584
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorJacobs Jr, DRen_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorPolak, JFen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorKlein, BEen_US
dc.contributor.authorOuyang, Pen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:31Z-
dc.date.available2013-05-28T06:14:31Z-
dc.date.issued2007en_US
dc.identifier.citationAnnals Of Neurology, 2007, v. 62 n. 6, p. 618-624en_US
dc.identifier.issn0364-5134en_US
dc.identifier.urihttp://hdl.handle.net/10722/183536-
dc.description.abstractObjective: Arterial stiffness is a newly recognized risk factor for stroke. Whether this is mediated by small- or large-artery disease is unknown. In this study, we examined the relationship between arterial stiffness and retinal vascular caliber. Methods: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). Retinal arteriolar and venular calibers were measured from retinal photographs according to standardized protocols. Small- and large-artery compliance was determined from pulse contour analysis. Results: After adjusting for age, sex, blood pressure, diabetes, smoking, lipid profile, and other risk factors, reduced large-artery compliance was associated with smaller retinal arteriolar caliber; each standard deviation decrease in large-artery compliance was associated with a 0.70μm (p = 0.002) decrease in retinal arteriolar caliber. After adjusting for the same set of risk factors, reduced small-artery compliance was associated with wider retinal venular caliber; each standard deviation decrease in small artery compliance was associated with a 1.43μm (p = 0.001) increase in retinal venular caliber. These associations remained significant after further adjustments for large-vessel atherosclerosis (carotid intima-media thickness, coronary artery calcium, and ankle-arm index). Interpretation: Reduced arterial wall compliance in large arterial beds is associated with retinal arteriolar narrowing, whereas reduced arterial wall compliance in small arterial beds is associated with retinal venular widening. These data may provide further insights into the effects of altered arterial stiffness on the cerebral microcirculation. © 2007 American Neurological Association Published by Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/76507645en_US
dc.relation.ispartofAnnals of Neurologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshArterioles - Physiopathologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracranial Arteriosclerosis - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRadial Artery - Physiopathologyen_US
dc.subject.meshRetinal Vessels - Physiopathologyen_US
dc.subject.meshVasomotor System - Physiopathologyen_US
dc.subject.meshVenules - Physiopathologyen_US
dc.titleArterial compliance and retinal vascular caliber in cerebrovascular diseaseen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ana.21236en_US
dc.identifier.pmid17918248-
dc.identifier.scopuseid_2-s2.0-37849026706en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37849026706&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue6en_US
dc.identifier.spage618en_US
dc.identifier.epage624en_US
dc.identifier.isiWOS:000252123700011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridIslam, FMA=35446440500en_US
dc.identifier.scopusauthoridJacobs Jr, DR=24495657500en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridPolak, JF=7401546724en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridKlein, BE=35433541400en_US
dc.identifier.scopusauthoridOuyang, P=36485193000en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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