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Article: Age-related macular degeneration and cancer mortality in the atherosclerosis risk in communities study

TitleAge-related macular degeneration and cancer mortality in the atherosclerosis risk in communities study
Authors
Issue Date2007
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.com
Citation
Archives Of Ophthalmology, 2007, v. 125 n. 9, p. 1241-1247 How to Cite?
AbstractObjective: To examine the prospective association of early age-related macular degeneration (AMD) with cancer mortality. Methods: A population-based cohort study of 10 029 persons aged 49 to 73 years free of cancer. The AMD signs were evaluated from retinal photographs taken in 1993 through 1995. Cancer mortality was determined from death records. Results: There were 464 cases of early AMD. Over 10 years, there were 234 cancer deaths (71 lung cancer deaths). After controlling for age, sex, race, field center, education, smoking status, pack-years of smoking, body mass index (calculated as weight in kilograms divided by height in meters squared), and diabetes mellitus, early AMD was associated with cancer mortality (rate ratio [RR], 1.68; 95% confidence interval [CI], 1.03-2.73). This association was overall stronger in African American individuals (RR, 3.93; 95% CI, 1.67-9.22) than white individuals (RR, 1.28; 95% CI, 0.71-2.32) and for lung cancer deaths (RR, 2.14; 95% CI, 0.97-4.72) than non-lung cancer deaths (RR, 1.50; 95% CI, 0.81-2.78). In African American individuals, early AMD was associated with a 5-fold higher risk of lung cancer deaths (RR, 5.28; 95% CI, 1.52-18.40). Conclusions: Middle-aged African American individuals with early AMD may be at increased risk of dying of cancer, particularly lung cancer. This association was not present in white individuals and needs confirmation in other studies. ©2007 American Medical Association. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/183528
ISSN
2014 Impact Factor: 4.399
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorShankar, Aen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorFolsom, ARen_US
dc.contributor.authorCouper, DJen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:26Z-
dc.date.available2013-05-28T06:14:26Z-
dc.date.issued2007en_US
dc.identifier.citationArchives Of Ophthalmology, 2007, v. 125 n. 9, p. 1241-1247en_US
dc.identifier.issn0003-9950en_US
dc.identifier.urihttp://hdl.handle.net/10722/183528-
dc.description.abstractObjective: To examine the prospective association of early age-related macular degeneration (AMD) with cancer mortality. Methods: A population-based cohort study of 10 029 persons aged 49 to 73 years free of cancer. The AMD signs were evaluated from retinal photographs taken in 1993 through 1995. Cancer mortality was determined from death records. Results: There were 464 cases of early AMD. Over 10 years, there were 234 cancer deaths (71 lung cancer deaths). After controlling for age, sex, race, field center, education, smoking status, pack-years of smoking, body mass index (calculated as weight in kilograms divided by height in meters squared), and diabetes mellitus, early AMD was associated with cancer mortality (rate ratio [RR], 1.68; 95% confidence interval [CI], 1.03-2.73). This association was overall stronger in African American individuals (RR, 3.93; 95% CI, 1.67-9.22) than white individuals (RR, 1.28; 95% CI, 0.71-2.32) and for lung cancer deaths (RR, 2.14; 95% CI, 0.97-4.72) than non-lung cancer deaths (RR, 1.50; 95% CI, 0.81-2.78). In African American individuals, early AMD was associated with a 5-fold higher risk of lung cancer deaths (RR, 5.28; 95% CI, 1.52-18.40). Conclusions: Middle-aged African American individuals with early AMD may be at increased risk of dying of cancer, particularly lung cancer. This association was not present in white individuals and needs confirmation in other studies. ©2007 American Medical Association. All rights reserved.en_US
dc.languageengen_US
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archopthalmol.comen_US
dc.relation.ispartofArchives of Ophthalmologyen_US
dc.subject.meshAfrican Continental Ancestry Group - Statistics & Numerical Dataen_US
dc.subject.meshAgeden_US
dc.subject.meshAtherosclerosis - Mortalityen_US
dc.subject.meshCause Of Deathen_US
dc.subject.meshEuropean Continental Ancestry Group - Statistics & Numerical Dataen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMacular Degeneration - Classification - Mortalityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms - Mortalityen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.titleAge-related macular degeneration and cancer mortality in the atherosclerosis risk in communities studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1001/archopht.125.9.1241en_US
dc.identifier.pmid17846365-
dc.identifier.scopuseid_2-s2.0-34548620610en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548620610&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume125en_US
dc.identifier.issue9en_US
dc.identifier.spage1241en_US
dc.identifier.epage1247en_US
dc.identifier.isiWOS:000249342100013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridShankar, A=12138932300en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridFolsom, AR=36043809200en_US
dc.identifier.scopusauthoridCouper, DJ=7004067300en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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