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Article: Orbital Langerhans Cell Histiocytosis in Adults

TitleOrbital Langerhans Cell Histiocytosis in Adults
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2007, v. 114 n. 8, p. 1569-1573 How to Cite?
AbstractPurpose: To report 3 patients with adult-onset orbital Langerhans cell histiocytosis (LCH). Design: Retrospective interventional case reports. Participants: Three adult patients with orbital LCH. Methods: Case reports from 2 different clinics and review of the scientific literature. Main Outcome Measures: Clinical course and radiologic and histologic findings. Results: Three healthy patients, aged 20 to 36 (mean, 27) years, presented with biopsy-proven unilateral orbital LCH. The initial presenting complaints were mainly orbital pain and headache with or without orbital swelling and minimal effect on ocular movements. There was radiologic evidence of disease centered on the greater wing of sphenoid bone in all cases. Biopsy via lateral canthotomy was performed with LCH confirmed based on histologic and immunohistochemical findings. There was no evidence of disease elsewhere on systemic investigations. One patient had curettage and intralesional corticosteroids, 1 patient had a craniotomy for more complete resection of the lesion, and the third patient was referred for radiotherapy. All patients achieved complete resolution of symptoms and signs. None of the patients demonstrated any evidence of distant or recurrent disease at follow-up. Conclusions: Orbital LCH in adults is a rare, usually unifocal, and relatively benign disease most commonly affecting the greater wing of sphenoid bone, where there is still active bone marrow in young adults. There is no consensus on cause or therapy, but our reported cases show that several treatment modalities are effective. © 2007 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183525
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorSelva, Den_US
dc.contributor.authorMcnab, AAen_US
dc.date.accessioned2013-05-28T06:14:25Z-
dc.date.available2013-05-28T06:14:25Z-
dc.date.issued2007en_US
dc.identifier.citationOphthalmology, 2007, v. 114 n. 8, p. 1569-1573en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183525-
dc.description.abstractPurpose: To report 3 patients with adult-onset orbital Langerhans cell histiocytosis (LCH). Design: Retrospective interventional case reports. Participants: Three adult patients with orbital LCH. Methods: Case reports from 2 different clinics and review of the scientific literature. Main Outcome Measures: Clinical course and radiologic and histologic findings. Results: Three healthy patients, aged 20 to 36 (mean, 27) years, presented with biopsy-proven unilateral orbital LCH. The initial presenting complaints were mainly orbital pain and headache with or without orbital swelling and minimal effect on ocular movements. There was radiologic evidence of disease centered on the greater wing of sphenoid bone in all cases. Biopsy via lateral canthotomy was performed with LCH confirmed based on histologic and immunohistochemical findings. There was no evidence of disease elsewhere on systemic investigations. One patient had curettage and intralesional corticosteroids, 1 patient had a craniotomy for more complete resection of the lesion, and the third patient was referred for radiotherapy. All patients achieved complete resolution of symptoms and signs. None of the patients demonstrated any evidence of distant or recurrent disease at follow-up. Conclusions: Orbital LCH in adults is a rare, usually unifocal, and relatively benign disease most commonly affecting the greater wing of sphenoid bone, where there is still active bone marrow in young adults. There is no consensus on cause or therapy, but our reported cases show that several treatment modalities are effective. © 2007 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers - Metabolismen_US
dc.subject.meshHistiocytosis, Langerhans-Cell - Metabolism - Pathology - Radiographyen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshOrbital Diseases - Metabolism - Pathology - Radiographyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSphenoid Bone - Pathology - Radiographyen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleOrbital Langerhans Cell Histiocytosis in Adultsen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2006.10.056en_US
dc.identifier.pmid17337061-
dc.identifier.scopuseid_2-s2.0-34547226007en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547226007&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume114en_US
dc.identifier.issue8en_US
dc.identifier.spage1569en_US
dc.identifier.epage1573en_US
dc.identifier.isiWOS:000248387400023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridSelva, D=7006466409en_US
dc.identifier.scopusauthoridMcNab, AA=7005498604en_US

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