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Article: Diabetic retinopathy and the risk of coronary heart disease: The atherosclerosis risk in communities study

TitleDiabetic retinopathy and the risk of coronary heart disease: The atherosclerosis risk in communities study
Authors
Issue Date2007
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2007, v. 30 n. 7, p. 1742-1746 How to Cite?
AbstractOBJECTIVE - We sought to examine the relation of diabetic retinopathy to incident coronary heart disease (CHD). RESEARCH DESIGN AND METHODS - A population-based, prospective cohort study consisting of 1,524 middle-aged individuals with type 2 diabetes without prevalent CHD and stroke at baseline was conducted. Diabetic retinopathy signs were graded from retinal photographs according to the Early Treatment for Diabetic Retinopathy Study severity scale. Incident CHD events (myocardial infarction, fatal CHD, or coronary revascularization) were identified and validated following standardized protocols. RESULTS - In our study, 214 (14.7%) participants had diabetic retinopathy. Over an average follow-up of 7.8 years, there were 209 (13.7%) incident CHD events. After controlling for age, sex, race, study center, fasting glucose, A1C, duration of diabetes, blood pressure, antihypertensive treatment, cigarette smoking, BMI, and lipid profile, the presence of diabetic retinopathy was associated with a twofold higher risk of incident CHD events (hazard rate ratio [HR] 2.07 [95% CI 1.38-3.11]) and a threefold higher risk of fatal CHD (3.35 [1.40-8.01]). Further adjustments for inflammatory markers, carotid artery intima-media thickness, or nephropathy had minimal impact on the association. The increased risk of CHD was significant in both men (1.89 [1.08-3.31]) and women (2.16 [1.16-4.02]) with diabetic retinopathy. CONCLUSIONS - In individuals with type 2 diabetes, the presence of retinopathy signifies an increased CHD risk, independent of known risk factors. Our data support the role of microvascular disease in the pathogenesis of CHD in diabetes. © 2007 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/183524
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
ISI Accession Number ID
References
Errata

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorJie, JWen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorCouper, DJen_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:24Z-
dc.date.available2013-05-28T06:14:24Z-
dc.date.issued2007en_US
dc.identifier.citationDiabetes Care, 2007, v. 30 n. 7, p. 1742-1746en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10722/183524-
dc.description.abstractOBJECTIVE - We sought to examine the relation of diabetic retinopathy to incident coronary heart disease (CHD). RESEARCH DESIGN AND METHODS - A population-based, prospective cohort study consisting of 1,524 middle-aged individuals with type 2 diabetes without prevalent CHD and stroke at baseline was conducted. Diabetic retinopathy signs were graded from retinal photographs according to the Early Treatment for Diabetic Retinopathy Study severity scale. Incident CHD events (myocardial infarction, fatal CHD, or coronary revascularization) were identified and validated following standardized protocols. RESULTS - In our study, 214 (14.7%) participants had diabetic retinopathy. Over an average follow-up of 7.8 years, there were 209 (13.7%) incident CHD events. After controlling for age, sex, race, study center, fasting glucose, A1C, duration of diabetes, blood pressure, antihypertensive treatment, cigarette smoking, BMI, and lipid profile, the presence of diabetic retinopathy was associated with a twofold higher risk of incident CHD events (hazard rate ratio [HR] 2.07 [95% CI 1.38-3.11]) and a threefold higher risk of fatal CHD (3.35 [1.40-8.01]). Further adjustments for inflammatory markers, carotid artery intima-media thickness, or nephropathy had minimal impact on the association. The increased risk of CHD was significant in both men (1.89 [1.08-3.31]) and women (2.16 [1.16-4.02]) with diabetic retinopathy. CONCLUSIONS - In individuals with type 2 diabetes, the presence of retinopathy signifies an increased CHD risk, independent of known risk factors. Our data support the role of microvascular disease in the pathogenesis of CHD in diabetes. © 2007 by the American Diabetes Association.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetes Careen_US
dc.subject.meshAgeden_US
dc.subject.meshComorbidityen_US
dc.subject.meshCoronary Disease - Epidemiologyen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Epidemiologyen_US
dc.subject.meshDiabetic Retinopathy - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisken_US
dc.titleDiabetic retinopathy and the risk of coronary heart disease: The atherosclerosis risk in communities studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2337/dc07-0264en_US
dc.identifier.pmid17389333-
dc.identifier.scopuseid_2-s2.0-34447135411en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447135411&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue7en_US
dc.identifier.spage1742en_US
dc.identifier.epage1746en_US
dc.identifier.isiWOS:000247768400010-
dc.publisher.placeUnited Statesen_US
dc.relation.erratumdoi:10.2337/dc07-er10-
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridJie, JW=7701312737en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridCouper, DJ=7004067300en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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