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Article: Blood pressure and retinal arteriolar narrowing in children

TitleBlood pressure and retinal arteriolar narrowing in children
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/
Citation
Hypertension, 2007, v. 49 n. 5, p. 1156-1162 How to Cite?
AbstractRetinal arteriolar narrowing is a known response of hypertension and independently predicts cardiovascular mortality in adults. Whether elevated blood pressure leads to retinal arteriolar narrowing in young children is unknown. We examined the relationship of retinal vascular caliber and blood pressure levels in 2 population-based cohorts among children aged 6 to 8 years in Sydney, Australia (1572 children) and Singapore (380 children). Participants had digital retinal photographs and measurement of retinal arteriolar (or small artery) and venular (or small vein) caliber. Children with higher quartiles of blood pressure had significantly narrower retinal arterioles than those with lower blood pressure (retinal arteriolar caliber 162.8, 161.0, 157.8, and 157.1 μm (P for trend<0.001), comparing increasing quartiles of systolic blood pressure in Sydney, and 164.9.5, 164.0, 159.1, and 159.4 μm (P for trend=0.0024 in Singapore). After controlling for age, sex, race, body mass index, refraction, and birth parameters, each 10-mm Hg increase in systolic blood pressure was associated with narrowing of the retinal arterioles by 2.08 μm (95% confidence interval: 1.38 to 2.79; P<0.0001) in Sydney children and 1.43 μm (95% confidence interval: 0.27 to 2.59; P=0.016) in Singapore children. These associations were consistent across age, sex, body mass index, and birth parameters. Retinal venules were not affected by blood pressure. We conclude that higher childhood blood pressure is associated with retinal arteriolar narrowing. Our data provide evidence that the effects of elevated blood pressure may manifest early in life. © 2007 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183519
ISSN
2015 Impact Factor: 6.294
2015 SCImago Journal Rankings: 3.702
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorDe Haseth, Ken_US
dc.contributor.authorTaylor, Ben_US
dc.contributor.authorRochtchina, Een_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:21Z-
dc.date.available2013-05-28T06:14:21Z-
dc.date.issued2007en_US
dc.identifier.citationHypertension, 2007, v. 49 n. 5, p. 1156-1162en_US
dc.identifier.issn0194-911Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/183519-
dc.description.abstractRetinal arteriolar narrowing is a known response of hypertension and independently predicts cardiovascular mortality in adults. Whether elevated blood pressure leads to retinal arteriolar narrowing in young children is unknown. We examined the relationship of retinal vascular caliber and blood pressure levels in 2 population-based cohorts among children aged 6 to 8 years in Sydney, Australia (1572 children) and Singapore (380 children). Participants had digital retinal photographs and measurement of retinal arteriolar (or small artery) and venular (or small vein) caliber. Children with higher quartiles of blood pressure had significantly narrower retinal arterioles than those with lower blood pressure (retinal arteriolar caliber 162.8, 161.0, 157.8, and 157.1 μm (P for trend<0.001), comparing increasing quartiles of systolic blood pressure in Sydney, and 164.9.5, 164.0, 159.1, and 159.4 μm (P for trend=0.0024 in Singapore). After controlling for age, sex, race, body mass index, refraction, and birth parameters, each 10-mm Hg increase in systolic blood pressure was associated with narrowing of the retinal arterioles by 2.08 μm (95% confidence interval: 1.38 to 2.79; P<0.0001) in Sydney children and 1.43 μm (95% confidence interval: 0.27 to 2.59; P=0.016) in Singapore children. These associations were consistent across age, sex, body mass index, and birth parameters. Retinal venules were not affected by blood pressure. We conclude that higher childhood blood pressure is associated with retinal arteriolar narrowing. Our data provide evidence that the effects of elevated blood pressure may manifest early in life. © 2007 American Heart Association, Inc.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/en_US
dc.relation.ispartofHypertensionen_US
dc.subject.meshArterioles - Anatomy & Histologyen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshChilden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshMaleen_US
dc.subject.meshPhotographyen_US
dc.subject.meshRetinal Vessels - Anatomy & Histologyen_US
dc.titleBlood pressure and retinal arteriolar narrowing in childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1161/HYPERTENSIONAHA.106.085910en_US
dc.identifier.pmid17372033-
dc.identifier.scopuseid_2-s2.0-34247885897en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247885897&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue5en_US
dc.identifier.spage1156en_US
dc.identifier.epage1162en_US
dc.identifier.isiWOS:000245810300031-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridDe Haseth, K=15841326700en_US
dc.identifier.scopusauthoridTaylor, B=14047527900en_US
dc.identifier.scopusauthoridRochtchina, E=6701613193en_US
dc.identifier.scopusauthoridIslam, FMA=55399085000en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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