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Article: Is early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study

TitleIs early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Study
Authors
Issue Date2007
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2007, v. 91 n. 4, p. 430-433 How to Cite?
AbstractBackground/Purpose: Atherosclerosis and vascular stiffness have been implicated in the pathogenesis of age-related macular degeneration (AMD). The association of carotid artery stiffness, a measure of arterial elasticity reflecting early atherosclerosis, with early AMD, was examined in this study. Methods: A population-based, cross-sectional study of 9954 middle-aged people (age range 51-72 years). The presence of AMD signs was determined from fundus photographs according to the Wisconsin grading protocol. Carotid arterial stiffness was measured from high-resolution ultrasonic echo tracking of the left common carotid artery, and was defined as an adjusted arterial diameter change (AADCμ). A smaller AADC reflects greater carotid artery stiffness. The associations of pulse pressure and carotid artery intima-media thickness (IMT) with early AMD signs were also analysed. Results: In the study population, 454 (4.6%) had early AMD. The mean (SD) AADC was 403 (127) μ. After adjusting for age, sex, race/centre, education, cigarette smoking, fasting glucose, lipid profile and inflammatory markers, a smaller AADC was found to be not associated with early AMD (odds ratio 0.94; 95% confidence interval, 0.71 to 1.25) or its component lesions. Other measures of arterial stiffness (pulse pressure) and atherosclerosis (carotid IMT) were also not associated with early AMD. Conclusions: Carotid artery stiffness was not associated with signs of early AMD in this middle-aged population. These data provide no evidence of a link between age-related elastoid changes and early atherosclerotic processes in the carotid arteries and early AMD.
Persistent Identifierhttp://hdl.handle.net/10722/183517
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorLiao, Den_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorJie, JWen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:19Z-
dc.date.available2013-05-28T06:14:19Z-
dc.date.issued2007en_US
dc.identifier.citationBritish Journal Of Ophthalmology, 2007, v. 91 n. 4, p. 430-433en_US
dc.identifier.issn0007-1161en_US
dc.identifier.urihttp://hdl.handle.net/10722/183517-
dc.description.abstractBackground/Purpose: Atherosclerosis and vascular stiffness have been implicated in the pathogenesis of age-related macular degeneration (AMD). The association of carotid artery stiffness, a measure of arterial elasticity reflecting early atherosclerosis, with early AMD, was examined in this study. Methods: A population-based, cross-sectional study of 9954 middle-aged people (age range 51-72 years). The presence of AMD signs was determined from fundus photographs according to the Wisconsin grading protocol. Carotid arterial stiffness was measured from high-resolution ultrasonic echo tracking of the left common carotid artery, and was defined as an adjusted arterial diameter change (AADCμ). A smaller AADC reflects greater carotid artery stiffness. The associations of pulse pressure and carotid artery intima-media thickness (IMT) with early AMD signs were also analysed. Results: In the study population, 454 (4.6%) had early AMD. The mean (SD) AADC was 403 (127) μ. After adjusting for age, sex, race/centre, education, cigarette smoking, fasting glucose, lipid profile and inflammatory markers, a smaller AADC was found to be not associated with early AMD (odds ratio 0.94; 95% confidence interval, 0.71 to 1.25) or its component lesions. Other measures of arterial stiffness (pulse pressure) and atherosclerosis (carotid IMT) were also not associated with early AMD. Conclusions: Carotid artery stiffness was not associated with signs of early AMD in this middle-aged population. These data provide no evidence of a link between age-related elastoid changes and early atherosclerotic processes in the carotid arteries and early AMD.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_US
dc.relation.ispartofBritish Journal of Ophthalmologyen_US
dc.subject.meshAgeden_US
dc.subject.meshAtherosclerosis - Complications - Ultrasonographyen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCarotid Artery, Common - Physiopathology - Ultrasonographyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshElasticityen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Complicationsen_US
dc.subject.meshMacular Degeneration - Etiology - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulsatile Flowen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.subject.meshVascular Resistanceen_US
dc.titleIs early age-related macular degeneration related to carotid artery stiffness? The Atherosclerosis Risk in Communities Studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1136/bjo.2006.106054en_US
dc.identifier.pmid17035267-
dc.identifier.pmcidPMC1994729-
dc.identifier.scopuseid_2-s2.0-34247274523en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247274523&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume91en_US
dc.identifier.issue4en_US
dc.identifier.spage430en_US
dc.identifier.epage433en_US
dc.identifier.isiWOS:000245037700010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridLiao, D=7202026792en_US
dc.identifier.scopusauthoridIslam, FMA=35446440500en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridJie, JW=7701312737en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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