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Article: Distribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children

TitleDistribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children
Authors
Issue Date2007
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2007, v. 48 n. 3, p. 1018-1024 How to Cite?
AbstractPURPOSE. To describe the distribution of retinal vascular calibers and their associations with ethnicity, gender, and birth parameters in children. METHODS. This was a school-based cross-sectional study of 768 children aged 7 to 9 years who participated in the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Participants had retinal photographs taken in 2001. Retinal vascular calibers were measured with computer-based program and summarized as average caliber of arterioles and venules in that eye. Associations of retinal vascular caliber with ethnicity, gender, and various birth factors were analyzed. RESULTS. In this population, the mean retinal arteriolar caliber was 156.4 μm (95% confidence interval [CI], 155.4-157.3) and venular caliber was 225.4 μm (95% CI, 224.1-226.8). The retinal arteriolar caliber was significantly narrower in Chinese (154.9 μm), compared with Malay (158.6 μm) and Indian (158.5 μm) children. Retinal venular caliber was also narrower in Chinese (223.3 μm) compared with Malay (230.8 μm) and Indian (229.0 μm) children. These differences were statistically significant, even after adjustments for age, gender, family income, parental education, body mass index, height, birth weight, axial length, and spherical equivalent (P = 0.05 for arteriolar caliber; P = 0.002 for venular caliber). In multivariate analysis, there were no significant gender differences in retinal vascular caliber. Birth factors, including birth weight, birth length, head circumference, and gestational age, were not significantly associated with changes in either retinal arteriolar or venular caliber. CONCLUSIONS. The results show ethnic variation in retinal vascular caliber in Singaporean children. No association of birth parameters with retinal vascular caliber was found. Because retinal vascular caliber is related to various cardiovascular and ocular diseases, it is possible that ethnic variations in retinal vascular caliber should be taken into consideration in future studies. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183516
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorIslam, FMAen_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorShankar, Aen_US
dc.contributor.authorDe Haseth, Ken_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:18Z-
dc.date.available2013-05-28T06:14:18Z-
dc.date.issued2007en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2007, v. 48 n. 3, p. 1018-1024en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183516-
dc.description.abstractPURPOSE. To describe the distribution of retinal vascular calibers and their associations with ethnicity, gender, and birth parameters in children. METHODS. This was a school-based cross-sectional study of 768 children aged 7 to 9 years who participated in the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Participants had retinal photographs taken in 2001. Retinal vascular calibers were measured with computer-based program and summarized as average caliber of arterioles and venules in that eye. Associations of retinal vascular caliber with ethnicity, gender, and various birth factors were analyzed. RESULTS. In this population, the mean retinal arteriolar caliber was 156.4 μm (95% confidence interval [CI], 155.4-157.3) and venular caliber was 225.4 μm (95% CI, 224.1-226.8). The retinal arteriolar caliber was significantly narrower in Chinese (154.9 μm), compared with Malay (158.6 μm) and Indian (158.5 μm) children. Retinal venular caliber was also narrower in Chinese (223.3 μm) compared with Malay (230.8 μm) and Indian (229.0 μm) children. These differences were statistically significant, even after adjustments for age, gender, family income, parental education, body mass index, height, birth weight, axial length, and spherical equivalent (P = 0.05 for arteriolar caliber; P = 0.002 for venular caliber). In multivariate analysis, there were no significant gender differences in retinal vascular caliber. Birth factors, including birth weight, birth length, head circumference, and gestational age, were not significantly associated with changes in either retinal arteriolar or venular caliber. CONCLUSIONS. The results show ethnic variation in retinal vascular caliber in Singaporean children. No association of birth parameters with retinal vascular caliber was found. Because retinal vascular caliber is related to various cardiovascular and ocular diseases, it is possible that ethnic variations in retinal vascular caliber should be taken into consideration in future studies. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.titleDistribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1167/iovs.06-0978en_US
dc.identifier.pmid17325141-
dc.identifier.scopuseid_2-s2.0-34047259832en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34047259832&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue3en_US
dc.identifier.spage1018en_US
dc.identifier.epage1024en_US
dc.identifier.isiWOS:000244686500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridIslam, FMA=35446440500en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridShankar, A=12138932300en_US
dc.identifier.scopusauthoridDe Haseth, K=15841326700en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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