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Article: Insulin signaling in fatty acid and fat synthesis: A transcriptional perspective

TitleInsulin signaling in fatty acid and fat synthesis: A transcriptional perspective
Authors
Issue Date2010
PublisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/coph
Citation
Current Opinion In Pharmacology, 2010, v. 10 n. 6, p. 684-691 How to Cite?
AbstractTranscription of enzymes involved in FA and TAG synthesis is coordinately induced in lipogenic tissues by feeding and insulin treatment. The three major transcription factors involved are USF, SREBP-1c, and LXRα. New insights into the insulin-signaling pathway(s) that control(s) lipogenic gene transcription via these factors have recently been revealed. Dephosphorylation/activation of DNA-PK by PP1 causes phosphorylation of USF that in turn recruits P/CAF to be acetylated for transcriptional activation. SREBP-1c can be induced by mTORC1, bifurcating lipogenesis from AKT-activated gluconeogenesis. LXRα may serve as a glucose sensor and, along with ChREBP, may activate lipogenic genes in the fed state. Dysregulation of FA and TAG metabolism often contributes to metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Transcription factors and signaling molecules involved in transcriptional activation of FA and TAG synthesis represent attractive targets for the prevention and treatment of metabolic diseases. © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/183382
ISSN
2015 Impact Factor: 4.769
2015 SCImago Journal Rankings: 2.142
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, RHFen_US
dc.contributor.authorSul, HSen_US
dc.date.accessioned2013-05-27T07:11:39Z-
dc.date.available2013-05-27T07:11:39Z-
dc.date.issued2010en_US
dc.identifier.citationCurrent Opinion In Pharmacology, 2010, v. 10 n. 6, p. 684-691en_US
dc.identifier.issn1471-4892en_US
dc.identifier.urihttp://hdl.handle.net/10722/183382-
dc.description.abstractTranscription of enzymes involved in FA and TAG synthesis is coordinately induced in lipogenic tissues by feeding and insulin treatment. The three major transcription factors involved are USF, SREBP-1c, and LXRα. New insights into the insulin-signaling pathway(s) that control(s) lipogenic gene transcription via these factors have recently been revealed. Dephosphorylation/activation of DNA-PK by PP1 causes phosphorylation of USF that in turn recruits P/CAF to be acetylated for transcriptional activation. SREBP-1c can be induced by mTORC1, bifurcating lipogenesis from AKT-activated gluconeogenesis. LXRα may serve as a glucose sensor and, along with ChREBP, may activate lipogenic genes in the fed state. Dysregulation of FA and TAG metabolism often contributes to metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Transcription factors and signaling molecules involved in transcriptional activation of FA and TAG synthesis represent attractive targets for the prevention and treatment of metabolic diseases. © 2010.en_US
dc.languageengen_US
dc.publisherElsevier Ltd, Current Opinion Journals. The Journal's web site is located at http://www.elsevier.com/locate/cophen_US
dc.relation.ispartofCurrent Opinion in Pharmacologyen_US
dc.titleInsulin signaling in fatty acid and fat synthesis: A transcriptional perspectiveen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.coph.2010.08.004en_US
dc.identifier.pmid20817607-
dc.identifier.scopuseid_2-s2.0-78149500681en_US
dc.identifier.volume10en_US
dc.identifier.issue6en_US
dc.identifier.spage684en_US
dc.identifier.epage691en_US
dc.identifier.isiWOS:000284749400012-
dc.publisher.placeUnited Kingdomen_US

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