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Article: Epidemiological dynamics and phylogeography of influenza virus in southern China

TitleEpidemiological dynamics and phylogeography of influenza virus in southern China
Authors
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2013, v. 207 n. 1, p. 106-114 How to Cite?
AbstractBackground. Understanding the epidemiological dynamics of influenza virus is central to surveillance and vaccine strain selection. It has been suggested that tropical and subtropical regions represent the global source of influenza epidemics. However, our understanding of the epidemiological dynamics of influenza virus in these regions is limited by a relative lack of long-term data. Methods. We analyzed epidemiological and virological data on influenza recorded over a period of 15 years from the metropolitan city of Shenzhen in subtropical southern China. We used wavelet analysis to determine the periodicity of influenza epidemics and molecular phylogeographic analysis to investigate the role of Shenzhen and southern China in the global evolution of influenza virus. Results. We show that southern China is unlikely to represent an epicenter of global influenza activity, because activity in Shenzhen is characterized by significant annual cycles, multiple viral introductions every year, limited persistence across epidemic seasons, and viruses that generally are not positioned on the trunk of the global influenza virus phylogeny. Conclusions. We propose that novel influenza viruses emerge and evolve in multiple geographic localities and that the global evolution of influenza virus is complex and does not simply originate from a southern Chinese epicenter. © The Author 2012.
Persistent Identifierhttp://hdl.handle.net/10722/182379
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, Xen_US
dc.contributor.authorTan, Yen_US
dc.contributor.authorHe, Men_US
dc.contributor.authorLam, TTYen_US
dc.contributor.authorLu, Xen_US
dc.contributor.authorViboud, Cen_US
dc.contributor.authorHe, Jen_US
dc.contributor.authorZhang, Sen_US
dc.contributor.authorLu, Jen_US
dc.contributor.authorWu, Cen_US
dc.contributor.authorFang, Sen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorXie, Xen_US
dc.contributor.authorMa, Hen_US
dc.contributor.authorNelson, MIen_US
dc.contributor.authorKung, HFen_US
dc.contributor.authorHolmes, ECen_US
dc.contributor.authorCheng, Jen_US
dc.date.accessioned2013-04-23T08:21:16Z-
dc.date.available2013-04-23T08:21:16Z-
dc.date.issued2013en_US
dc.identifier.citationJournal Of Infectious Diseases, 2013, v. 207 n. 1, p. 106-114en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/182379-
dc.description.abstractBackground. Understanding the epidemiological dynamics of influenza virus is central to surveillance and vaccine strain selection. It has been suggested that tropical and subtropical regions represent the global source of influenza epidemics. However, our understanding of the epidemiological dynamics of influenza virus in these regions is limited by a relative lack of long-term data. Methods. We analyzed epidemiological and virological data on influenza recorded over a period of 15 years from the metropolitan city of Shenzhen in subtropical southern China. We used wavelet analysis to determine the periodicity of influenza epidemics and molecular phylogeographic analysis to investigate the role of Shenzhen and southern China in the global evolution of influenza virus. Results. We show that southern China is unlikely to represent an epicenter of global influenza activity, because activity in Shenzhen is characterized by significant annual cycles, multiple viral introductions every year, limited persistence across epidemic seasons, and viruses that generally are not positioned on the trunk of the global influenza virus phylogeny. Conclusions. We propose that novel influenza viruses emerge and evolve in multiple geographic localities and that the global evolution of influenza virus is complex and does not simply originate from a southern Chinese epicenter. © The Author 2012.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEpidemicsen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshHumansen_US
dc.subject.meshInfluenza A Virus - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshInfluenza B Virus - Classification - Genetics - Isolation & Purificationen_US
dc.subject.meshInfluenza, Human - Epidemiology - Prevention & Control - Virologyen_US
dc.subject.meshMadin Darby Canine Kidney Cellsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPeriodicityen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPhylogeographyen_US
dc.subject.meshSeasonsen_US
dc.titleEpidemiological dynamics and phylogeography of influenza virus in southern Chinaen_US
dc.typeArticleen_US
dc.identifier.emailLam, TTY: ttylam@hku.hken_US
dc.identifier.authorityLam, TTY=rp01733en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/infdis/jis526en_US
dc.identifier.pmid22930808-
dc.identifier.scopuseid_2-s2.0-84872976710en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872976710&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume207en_US
dc.identifier.issue1en_US
dc.identifier.spage106en_US
dc.identifier.epage114en_US
dc.identifier.isiWOS:000312604200014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheng, X=55570405100en_US
dc.identifier.scopusauthoridTan, Y=55569683400en_US
dc.identifier.scopusauthoridHe, M=55571181400en_US
dc.identifier.scopusauthoridLam, TTY=36775821700en_US
dc.identifier.scopusauthoridLu, X=55571121200en_US
dc.identifier.scopusauthoridViboud, C=6701923799en_US
dc.identifier.scopusauthoridHe, J=55570871400en_US
dc.identifier.scopusauthoridZhang, S=55569780200en_US
dc.identifier.scopusauthoridLu, J=55571621200en_US
dc.identifier.scopusauthoridWu, C=55571038600en_US
dc.identifier.scopusauthoridFang, S=55569818000en_US
dc.identifier.scopusauthoridWang, X=37040080500en_US
dc.identifier.scopusauthoridXie, X=37035421600en_US
dc.identifier.scopusauthoridMa, H=7403096095en_US
dc.identifier.scopusauthoridNelson, MI=15758216500en_US
dc.identifier.scopusauthoridKung, HF=7402514190en_US
dc.identifier.scopusauthoridHolmes, EC=35433598300en_US
dc.identifier.scopusauthoridCheng, J=7405939143en_US

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