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Article: Functional magnetic resonance imaging of sound pressure level encoding in the rat central auditory system

TitleFunctional magnetic resonance imaging of sound pressure level encoding in the rat central auditory system
Authors
KeywordsAuditory Cortex
Bold
Fmri
Inferior Colliculus
Lateral Lemniscus
Medial Geniculate Body
Rat
Sound Pressure Level
Issue Date2013
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2013, v. 65, p. 119-126 How to Cite?
AbstractIntensity is an important physical property of a sound wave and is customarily reported as sound pressure level (SPL). Invasive techniques such as electrical recordings, which typically examine one brain region at a time, have been used to study neuronal encoding of SPL throughout the central auditory system. Non-invasive functional magnetic resonance imaging (fMRI) with large field of view can simultaneously examine multiple auditory structures. We applied fMRI to measure the hemodynamic responses in the rat brain during sound stimulation at seven SPLs over a 72. dB range. This study used a sparse temporal sampling paradigm to reduce the adverse effects of scanner noise. Hemodynamic responses were measured from the central nucleus of the inferior colliculus (CIC), external cortex of the inferior colliculus (ECIC), lateral lemniscus (LL), medial geniculate body (MGB), and auditory cortex (AC). BOLD signal changes generally increase significantly (p < 0.001) with SPL and the dependence is monotonic in CIC, ECIC, and LL. The ECIC has higher BOLD signal change than CIC and LL at high SPLs. The difference between BOLD signal changes at high and low SPLs is less in the MGB and AC. This suggests that the SPL dependences of the LL and IC are different from those in the MGB and AC and the SPL dependence of the CIC is different from that of the ECIC. These observations are likely related to earlier observations that neurons with firing rates that increase monotonically with SPL are dominant in the CIC, ECIC, and LL while non-monotonic neurons are dominant in the MGB and AC. Further, the IC's SPL dependence measured in this study is very similar to that measured in our earlier study using the continuous imaging method. Therefore, sparse temporal sampling may not be a prerequisite in auditory fMRI studies of the IC. © 2012 Elsevier Inc..
Persistent Identifierhttp://hdl.handle.net/10722/182345
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, JWen_US
dc.contributor.authorLau, Cen_US
dc.contributor.authorCheng, JSen_US
dc.contributor.authorXing, KKen_US
dc.contributor.authorZhou, IYen_US
dc.contributor.authorCheung, MMen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-04-23T08:19:30Z-
dc.date.available2013-04-23T08:19:30Z-
dc.date.issued2013en_US
dc.identifier.citationNeuroimage, 2013, v. 65, p. 119-126en_US
dc.identifier.issn1053-8119en_US
dc.identifier.urihttp://hdl.handle.net/10722/182345-
dc.description.abstractIntensity is an important physical property of a sound wave and is customarily reported as sound pressure level (SPL). Invasive techniques such as electrical recordings, which typically examine one brain region at a time, have been used to study neuronal encoding of SPL throughout the central auditory system. Non-invasive functional magnetic resonance imaging (fMRI) with large field of view can simultaneously examine multiple auditory structures. We applied fMRI to measure the hemodynamic responses in the rat brain during sound stimulation at seven SPLs over a 72. dB range. This study used a sparse temporal sampling paradigm to reduce the adverse effects of scanner noise. Hemodynamic responses were measured from the central nucleus of the inferior colliculus (CIC), external cortex of the inferior colliculus (ECIC), lateral lemniscus (LL), medial geniculate body (MGB), and auditory cortex (AC). BOLD signal changes generally increase significantly (p < 0.001) with SPL and the dependence is monotonic in CIC, ECIC, and LL. The ECIC has higher BOLD signal change than CIC and LL at high SPLs. The difference between BOLD signal changes at high and low SPLs is less in the MGB and AC. This suggests that the SPL dependences of the LL and IC are different from those in the MGB and AC and the SPL dependence of the CIC is different from that of the ECIC. These observations are likely related to earlier observations that neurons with firing rates that increase monotonically with SPL are dominant in the CIC, ECIC, and LL while non-monotonic neurons are dominant in the MGB and AC. Further, the IC's SPL dependence measured in this study is very similar to that measured in our earlier study using the continuous imaging method. Therefore, sparse temporal sampling may not be a prerequisite in auditory fMRI studies of the IC. © 2012 Elsevier Inc..en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_US
dc.relation.ispartofNeuroImageen_US
dc.subjectAuditory Cortexen_US
dc.subjectBolden_US
dc.subjectFmrien_US
dc.subjectInferior Colliculusen_US
dc.subjectLateral Lemniscusen_US
dc.subjectMedial Geniculate Bodyen_US
dc.subjectRaten_US
dc.subjectSound Pressure Levelen_US
dc.titleFunctional magnetic resonance imaging of sound pressure level encoding in the rat central auditory systemen_US
dc.typeArticleen_US
dc.identifier.emailZhou, IY: izhou@hku.hken_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityZhou, IY=rp01739en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2012.09.069en_US
dc.identifier.pmid23041525-
dc.identifier.scopuseid_2-s2.0-84868252443en_US
dc.identifier.hkuros225435-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84868252443&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume65en_US
dc.identifier.spage119en_US
dc.identifier.epage126en_US
dc.identifier.isiWOS:000312283900011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, JW=54979931500en_US
dc.identifier.scopusauthoridLau, C=36655866600en_US
dc.identifier.scopusauthoridCheng, JS=55443910700en_US
dc.identifier.scopusauthoridXing, KK=35886305100en_US
dc.identifier.scopusauthoridZhou, IY=35424838500en_US
dc.identifier.scopusauthoridCheung, MM=55443747800en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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