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Article: In vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brains.

TitleIn vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brains.
Authors
Issue Date2011
Citation
Conference Proceedings : ... Annual International Conference Of The Ieee Engineering In Medicine And Biology Society. Ieee Engineering In Medicine And Biology Society. Conference, 2011, v. 2011, p. 7005-7008 How to Cite?
AbstractThis study explored the feasibility of high-resolution Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) for in vivo assessments of the development and reorganization of retinal and visual callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Using MEMRI, intravitreal Mn(2+) injection into one eye resulted in maximal T1-weighted hyperintensity in neonatal contralateral superior colliculus (SC) 8 hours after administration, whereas in adult contralateral SC signal increase continued at 1 day post-injection. Notably, mild but significant Mn(2+) enhancement was observed in the ipsilateral SC in normal neonatal rats, and in adult rats after neonatal monocular enucleation (ME) but not in normal adult rats. Upon intracortical Mn(2+) injection to the visual cortex, neonatal binocularly-enucleated (BE) rats showed an enhancement of a larger projection area, via the splenium of corpus callosum to the V1/V2 transition zone of the contralateral hemisphere in comparison to normal rats. For DTI, the retinal pathways projected from the enucleated eyes possessed lower fractional anisotropy (FA) 6 weeks after BE and ME. Interestingly, in the optic nerve projected from the remaining eye in ME rats a significantly higher FA was observed compared to normal rats. The results of this study are potentially important for understanding the axonal transport, microstructural reorganization and functional activities in the living visual brain during early postnatal development and plasticity in a global and longitudinal setting.
Persistent Identifierhttp://hdl.handle.net/10722/182344
ISSN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_US
dc.contributor.authorCheng, JSen_US
dc.contributor.authorFan, Sen_US
dc.contributor.authorZhou, IYen_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2013-04-23T08:19:29Z-
dc.date.available2013-04-23T08:19:29Z-
dc.date.issued2011en_US
dc.identifier.citationConference Proceedings : ... Annual International Conference Of The Ieee Engineering In Medicine And Biology Society. Ieee Engineering In Medicine And Biology Society. Conference, 2011, v. 2011, p. 7005-7008en_US
dc.identifier.issn1557-170Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/182344-
dc.description.abstractThis study explored the feasibility of high-resolution Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) for in vivo assessments of the development and reorganization of retinal and visual callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Using MEMRI, intravitreal Mn(2+) injection into one eye resulted in maximal T1-weighted hyperintensity in neonatal contralateral superior colliculus (SC) 8 hours after administration, whereas in adult contralateral SC signal increase continued at 1 day post-injection. Notably, mild but significant Mn(2+) enhancement was observed in the ipsilateral SC in normal neonatal rats, and in adult rats after neonatal monocular enucleation (ME) but not in normal adult rats. Upon intracortical Mn(2+) injection to the visual cortex, neonatal binocularly-enucleated (BE) rats showed an enhancement of a larger projection area, via the splenium of corpus callosum to the V1/V2 transition zone of the contralateral hemisphere in comparison to normal rats. For DTI, the retinal pathways projected from the enucleated eyes possessed lower fractional anisotropy (FA) 6 weeks after BE and ME. Interestingly, in the optic nerve projected from the remaining eye in ME rats a significantly higher FA was observed compared to normal rats. The results of this study are potentially important for understanding the axonal transport, microstructural reorganization and functional activities in the living visual brain during early postnatal development and plasticity in a global and longitudinal setting.en_US
dc.languageengen_US
dc.relation.ispartofConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conferenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshAnisotropyen_US
dc.subject.meshAxons - Pathologyen_US
dc.subject.meshBrain - Pathology - Physiologyen_US
dc.subject.meshBrain Mapping - Methodsen_US
dc.subject.meshDiffusion Tensor Imaging - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshManganese - Pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshNeuronal Plasticityen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRetina - Pathology - Physiologyen_US
dc.subject.meshVision, Ocular - Physiologyen_US
dc.titleIn vivo manganese-enhanced MRI and diffusion tensor imaging of developing and impaired visual brains.en_US
dc.typeArticleen_US
dc.identifier.emailZhou, IY: izhou@hku.hken_US
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_US
dc.identifier.authorityZhou, IY=rp01739en_US
dc.identifier.authorityWu, EX=rp00193en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid22255951-
dc.identifier.scopuseid_2-s2.0-84864580489en_US
dc.identifier.volume2011en_US
dc.identifier.spage7005en_US
dc.identifier.epage7008en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, KC=34968940300en_US
dc.identifier.scopusauthoridCheng, JS=55443910700en_US
dc.identifier.scopusauthoridFan, S=36514618100en_US
dc.identifier.scopusauthoridZhou, IY=35424838500en_US
dc.identifier.scopusauthoridWu, EX=7202128034en_US

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