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Conference Paper: MRI background enhancement: Its relationship with breast density and breast cancer risk

TitleMRI background enhancement: Its relationship with breast density and breast cancer risk
Authors
Issue Date2007
PublisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
Citation
American Society of Clinical Oncology (ASCO) 43rd Annual Meeting, Chicago, Il., 1-5 June 2007. In Journal of Clinical Oncology, 2007, v. 25 n. 18S, p. Abstract no. 1539 How to Cite?
AbstractBackground: Increased breast density increases breast cancer risk. MRI breast is increasingly used for imaging as unlike mammography, the sensitivity of MRI breast is not affected by breast density but rather, the amount of background enhancement. It has been suggested that increased background enhancement may be related to the amount of proliferative breast tissue present; hence this may also be related to increased breast cancer risk. To date there have been no study published assessing background enhancement and its relation to breast cancer risk. Method: A retrospective review 45 mammography films and breast MRI scans of 36 patients (9 bilateral) with normal breast imaging was performed and scored independently by 3 radiologists for breast density using BI-RADS criteria. MRI breast density was scored on the non-contrast enhanced T1-weighted series whereas background enhancement was quantified on the first contrast-enhanced T1-weighted fat-suppressed series. Background enhancement was scored as none-minimal, mild, moderate, marked. Weighted kappa was used to assess the inter-modality agreement. A partial approximation to the Gail risk score was calculated from the available risk factors (age, menarche, number of biopsies, births and relatives with breast cancer), using coefficients from a Caucasian population; the resulting values were converted to ranks and was correlated with background enhancement. Result: There was substantial within-reader agreement between mammographic and MRI density (kappa=0.68; p=0.001). There were no correlation between background enhancement and breast density. All 6 patients with background-enhancement were pre-menopausal. Although not statistically significant (p<0.37), it is suggestive that 4 of the 6 (67%) had a history of breast cancer while only 6 of the 13 premenopausal non-enhancers (46%) had cancer. Moreover, the mean of the rank risk for enhancing premenopausal women was 29.5 while the non-enhancing pre-menopausal women was 16.6 (p=0.048 by one-tailed t-test). Conclusion: We found good correlation between mammographic and MRI breast density. There was no correlation between breast density and MRI background enhancement. There is a suggestion that MRI background enhancement may be associated with a higher risk of breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/182311
ISSN
2015 Impact Factor: 20.982
2015 SCImago Journal Rankings: 9.204

 

DC FieldValueLanguage
dc.contributor.authorKwong, A-
dc.contributor.authorRosenberg, J-
dc.contributor.authorVan den Bosch, MA-
dc.contributor.authorDaniel, BL-
dc.contributor.authorLo, G-
dc.contributor.authorIkeda, DM-
dc.date.accessioned2013-04-22T01:10:10Z-
dc.date.available2013-04-22T01:10:10Z-
dc.date.issued2007-
dc.identifier.citationAmerican Society of Clinical Oncology (ASCO) 43rd Annual Meeting, Chicago, Il., 1-5 June 2007. In Journal of Clinical Oncology, 2007, v. 25 n. 18S, p. Abstract no. 1539-
dc.identifier.issn0732-183X-
dc.identifier.urihttp://hdl.handle.net/10722/182311-
dc.description.abstractBackground: Increased breast density increases breast cancer risk. MRI breast is increasingly used for imaging as unlike mammography, the sensitivity of MRI breast is not affected by breast density but rather, the amount of background enhancement. It has been suggested that increased background enhancement may be related to the amount of proliferative breast tissue present; hence this may also be related to increased breast cancer risk. To date there have been no study published assessing background enhancement and its relation to breast cancer risk. Method: A retrospective review 45 mammography films and breast MRI scans of 36 patients (9 bilateral) with normal breast imaging was performed and scored independently by 3 radiologists for breast density using BI-RADS criteria. MRI breast density was scored on the non-contrast enhanced T1-weighted series whereas background enhancement was quantified on the first contrast-enhanced T1-weighted fat-suppressed series. Background enhancement was scored as none-minimal, mild, moderate, marked. Weighted kappa was used to assess the inter-modality agreement. A partial approximation to the Gail risk score was calculated from the available risk factors (age, menarche, number of biopsies, births and relatives with breast cancer), using coefficients from a Caucasian population; the resulting values were converted to ranks and was correlated with background enhancement. Result: There was substantial within-reader agreement between mammographic and MRI density (kappa=0.68; p=0.001). There were no correlation between background enhancement and breast density. All 6 patients with background-enhancement were pre-menopausal. Although not statistically significant (p<0.37), it is suggestive that 4 of the 6 (67%) had a history of breast cancer while only 6 of the 13 premenopausal non-enhancers (46%) had cancer. Moreover, the mean of the rank risk for enhancing premenopausal women was 29.5 while the non-enhancing pre-menopausal women was 16.6 (p=0.048 by one-tailed t-test). Conclusion: We found good correlation between mammographic and MRI breast density. There was no correlation between breast density and MRI background enhancement. There is a suggestion that MRI background enhancement may be associated with a higher risk of breast cancer.-
dc.languageeng-
dc.publisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/-
dc.relation.ispartofJournal of Clinical Oncology-
dc.titleMRI background enhancement: Its relationship with breast density and breast cancer risken_US
dc.typeConference_Paperen_US
dc.identifier.emailKwong, A: avakwong@HKUCC.hku.hk-
dc.description.natureabstract-
dc.identifier.hkuros136490-
dc.identifier.volume25-
dc.identifier.issue18S-
dc.identifier.spageAbstract no. 1539-
dc.identifier.epageAbstract no. 1539-
dc.publisher.placeUnited States-
dc.description.otherAmerican Society of Clinical Oncology (ASCO) 43rd Annual Meeting, Chicago, Il., 1-5 June 2007. In Journal of Clinical Oncology, 2007, v. 25 n. 18S, p. Abstract no. 1539-

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