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Article: Factors affecting false-negative breast sentinel node biopsy in Chinese patients

TitleFactors affecting false-negative breast sentinel node biopsy in Chinese patients
Authors
KeywordsAxillary dissection
Breast cancer
False-negative rate
Lymphatic mapping
Sentinel lymph node biopsy
Issue Date2007
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANS
Citation
Anz Journal Of Surgery, 2007, v. 77 n. 10, p. 866-869 How to Cite?
AbstractBackground: The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers. Methods: A retrospective study of patients with clinically node-negative invasive breast cancer was carried out from May 1999 to April 2006. A combination of radioisotope 99mtechnetium(Tc)-albumin sulfur colloid and Patent Blue V dye was used to identify the sentinel lymph node. Sentinel lymph node biopsy was followed by standard level I and II axillary dissection in all patients. Various clinicopathologic variables were analysed to determine factors associated with FN SLNB. Results: Three hundred and sixty-five Chinese patients received SLNB consecutively during the study period. Seventy-eight patients with neoadjuvant chemotherapy and 56 patients with in situ carcinoma were excluded. A total of 231 patients were studied. Sentinel lymph nodes were identified in 221 patients (95.7%). There were 10 FN, resulting in a FN rate of 12.5% and accuracy rate of 95.5%. Only the number of sentinel lymph node harvested was found to be a significant factor affecting FN rates on univariate (P < 0.009) and multivariate logistic regression (odds ratio: 2.65; 95% confidence interval: 2.57-2.73; P < 0.000). Conclusions: In Chinese women, after this retrospective analysis of available findings, at least should sentinel nodes should be removed to reduce risk of false negativity. © 2007 Royal Australasian College of Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/182273
ISSN
2015 Impact Factor: 1.158
2015 SCImago Journal Rankings: 0.432
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChok, KSHen_HK
dc.contributor.authorSuen, DTKen_HK
dc.contributor.authorLim, FMYen_HK
dc.contributor.authorLi, GKHen_HK
dc.contributor.authorKwong, Aen_HK
dc.date.accessioned2013-04-19T09:03:53Z-
dc.date.available2013-04-19T09:03:53Z-
dc.date.issued2007en_HK
dc.identifier.citationAnz Journal Of Surgery, 2007, v. 77 n. 10, p. 866-869en_HK
dc.identifier.issn1445-1433en_HK
dc.identifier.urihttp://hdl.handle.net/10722/182273-
dc.description.abstractBackground: The objective of the research was to validate our results on sentinel lymph node biopsy (SLNB) and to determine factors affecting false-negative (FN) rates of SLNB in Chinese patients with invasive breast cancers. Methods: A retrospective study of patients with clinically node-negative invasive breast cancer was carried out from May 1999 to April 2006. A combination of radioisotope 99mtechnetium(Tc)-albumin sulfur colloid and Patent Blue V dye was used to identify the sentinel lymph node. Sentinel lymph node biopsy was followed by standard level I and II axillary dissection in all patients. Various clinicopathologic variables were analysed to determine factors associated with FN SLNB. Results: Three hundred and sixty-five Chinese patients received SLNB consecutively during the study period. Seventy-eight patients with neoadjuvant chemotherapy and 56 patients with in situ carcinoma were excluded. A total of 231 patients were studied. Sentinel lymph nodes were identified in 221 patients (95.7%). There were 10 FN, resulting in a FN rate of 12.5% and accuracy rate of 95.5%. Only the number of sentinel lymph node harvested was found to be a significant factor affecting FN rates on univariate (P < 0.009) and multivariate logistic regression (odds ratio: 2.65; 95% confidence interval: 2.57-2.73; P < 0.000). Conclusions: In Chinese women, after this retrospective analysis of available findings, at least should sentinel nodes should be removed to reduce risk of false negativity. © 2007 Royal Australasian College of Surgeons.en_HK
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ANSen_HK
dc.relation.ispartofANZ Journal of Surgeryen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectAxillary dissectionen_HK
dc.subjectBreast canceren_HK
dc.subjectFalse-negative rateen_HK
dc.subjectLymphatic mappingen_HK
dc.subjectSentinel lymph node biopsyen_HK
dc.subject.meshAntineoplastic Agents - therapeutic use-
dc.subject.meshBreast Neoplasms - drug therapy - pathology - surgery-
dc.subject.meshReoperation - statistics and numerical data-
dc.subject.meshSentinel Lymph Node Biopsy-
dc.titleFactors affecting false-negative breast sentinel node biopsy in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, A=rp01734en_HK
dc.identifier.doi10.1111/j.1445-2197.2007.04260.xen_HK
dc.identifier.pmid17803550-
dc.identifier.scopuseid_2-s2.0-34548406607en_HK
dc.identifier.hkuros137403-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548406607&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue10en_HK
dc.identifier.spage866en_HK
dc.identifier.epage869en_HK
dc.identifier.isiWOS:000249164300019-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridChok, KSH=6508229426en_HK
dc.identifier.scopusauthoridSuen, DTK=8876971300en_HK
dc.identifier.scopusauthoridLim, FMY=20734567100en_HK
dc.identifier.scopusauthoridLi, GKH=15034790200en_HK
dc.identifier.scopusauthoridKwong, A=8913654300en_HK

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