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Article: Breast cancer in Chinese women younger than age 40: Are they different from their older counterparts?

TitleBreast cancer in Chinese women younger than age 40: Are they different from their older counterparts?
Authors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2008, v. 32 n. 12, p. 2554-2561 How to Cite?
AbstractBackground: Breast cancer in young women is uncommon, but when it does occur it has been reported to have aggressive biological characteristics. The incidence of breast cancer peaks at age 40 in Hong Kong Chinese women, earlier than in Caucasians. This study is the first to report the tumor characteristics and management of breast cancer in Chinese women younger than age 40 and a comparison with their older counterparts. Materials and methods: Demographic and clinicopathologic findings of 1,485 Chinese women with breast cancer seen during the period September 2003 to November 2006 were prospectively recorded, and comparisons were made between those who were under the age of 40 and those 40 years of age and older. These results were then compared with a reference population obtained from the Surveillance, Epidemiology and End Results (SEER) database between 2003 and 2004. Results: 17.6% of the women were younger than 40 years old, and age distribution was significantly different from women in the SEER database. The mean age at menarche was lower in women under age 40 (p < 0.0005), and age at first live birth was also higher (p = 0.017). The rate of first detection by screening mammography was significantly higher among women who were 40 of age and older (p = 0.002). Breast conservation surgery was more commonly performed in the younger age group of Chinese women, particularly when tumor size was less than 2 cm (p = 0.001). A significantly higher proportion of women under age 40 had breast reconstruction (p < 0.001). The majority of women presented with stage 0-II disease, but in the Chinese groups the younger patients presented at a later stage (p = 0.04). Younger women had higher pathological grade and poorly differentiated tumors (p = 0.02), more nodal involvement (p = 0.024), and lymphovascular permeation involvement (p < 0.001). The majority of tumors were ER and PR positive in both groups, but younger women had a higher proportion of cerbB2-positive tumors. Conclusion: Chinese women present with breast cancer at an earlier age. Younger women present with more advanced disease and more aggressive tumor characteristics. More ethnic-specific screening protocols and treatment decisions may benefit this group of patients. © 2008 Société Internationale de Chirurgie.
Persistent Identifierhttp://hdl.handle.net/10722/182265
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, Aen_HK
dc.contributor.authorCheung, Pen_HK
dc.contributor.authorChan, Sen_HK
dc.contributor.authorLau, Sen_HK
dc.date.accessioned2013-04-19T07:25:44Z-
dc.date.available2013-04-19T07:25:44Z-
dc.date.issued2008en_HK
dc.identifier.citationWorld Journal Of Surgery, 2008, v. 32 n. 12, p. 2554-2561en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/182265-
dc.description.abstractBackground: Breast cancer in young women is uncommon, but when it does occur it has been reported to have aggressive biological characteristics. The incidence of breast cancer peaks at age 40 in Hong Kong Chinese women, earlier than in Caucasians. This study is the first to report the tumor characteristics and management of breast cancer in Chinese women younger than age 40 and a comparison with their older counterparts. Materials and methods: Demographic and clinicopathologic findings of 1,485 Chinese women with breast cancer seen during the period September 2003 to November 2006 were prospectively recorded, and comparisons were made between those who were under the age of 40 and those 40 years of age and older. These results were then compared with a reference population obtained from the Surveillance, Epidemiology and End Results (SEER) database between 2003 and 2004. Results: 17.6% of the women were younger than 40 years old, and age distribution was significantly different from women in the SEER database. The mean age at menarche was lower in women under age 40 (p < 0.0005), and age at first live birth was also higher (p = 0.017). The rate of first detection by screening mammography was significantly higher among women who were 40 of age and older (p = 0.002). Breast conservation surgery was more commonly performed in the younger age group of Chinese women, particularly when tumor size was less than 2 cm (p = 0.001). A significantly higher proportion of women under age 40 had breast reconstruction (p < 0.001). The majority of women presented with stage 0-II disease, but in the Chinese groups the younger patients presented at a later stage (p = 0.04). Younger women had higher pathological grade and poorly differentiated tumors (p = 0.02), more nodal involvement (p = 0.024), and lymphovascular permeation involvement (p < 0.001). The majority of tumors were ER and PR positive in both groups, but younger women had a higher proportion of cerbB2-positive tumors. Conclusion: Chinese women present with breast cancer at an earlier age. Younger women present with more advanced disease and more aggressive tumor characteristics. More ethnic-specific screening protocols and treatment decisions may benefit this group of patients. © 2008 Société Internationale de Chirurgie.en_HK
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAsian Continental Ancestry Group - statistics and numerical data-
dc.subject.meshBreast Neoplasms - ethnology - pathology - therapy-
dc.subject.meshEuropean Continental Ancestry Group - statistics and numerical data-
dc.subject.meshRetrospective Studies-
dc.subject.meshSEER Program-
dc.titleBreast cancer in Chinese women younger than age 40: Are they different from their older counterparts?en_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, A=rp01734en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-008-9589-6en_HK
dc.identifier.pmid18408960-
dc.identifier.scopuseid_2-s2.0-56349138976en_HK
dc.identifier.hkuros141952-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56349138976&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2554en_HK
dc.identifier.epage2561en_HK
dc.identifier.isiWOS:000260968500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, A=8913654300en_HK
dc.identifier.scopusauthoridCheung, P=7202595368en_HK
dc.identifier.scopusauthoridChan, S=55455855300en_HK
dc.identifier.scopusauthoridLau, S=36118928300en_HK

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