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Article: Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?

TitleIs aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?
Authors
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal of Epidemiology, 2013, v. 42 n. 1, p. 318-328 How to Cite?
AbstractBACKGROUND: Mendelian randomization studies provide a means of assessing causal relations without interventions, but require valid genetic instruments. We assessed the credibility of aldehyde dehydrogenase 2 (ALDH2) as a genetic instrument for alcohol use in Southern Chinese men. METHODS: We genotyped the single nucleotide polymorphism rs671 of ALDH2 in 4867 men from the Guangzhou Biobank Cohort Study. We used linear regression to assess the strength of the association of ALDH2 variants with alcohol use, whether ALDH2 variants were independently associated with socio-economic position or other potential confounders and whether associations of ALDH2 variants with cardiovascular risk factors (systolic and diastolic blood pressure, HDL- and LDL-cholesterol, fasting glucose), triglycerides, body mass index, self reported cardiovascular disease, self-reported ischaemic heart disease, cognitive function (delayed 10-word recall and Mini Mental State Examination score) and liver function (alanine transaminase and aspartate transaminase) were fully mediated by alcohol use. RESULTS: The minor allele frequency (A) of ALDH2 was 0.29. The F statistic for ALDH2 variants was 75.0, suggesting that substantial weak instrument bias is unlikely. ALDH2 variants were not associated with socio-economic position, smoking or physical activity. ALDH2 variants were only associated with diastolic blood pressure and HDL-cholesterol, but these genetic associations with blood pressure and HDL-cholesterol were attenuated after adjusting for alcohol use, suggesting the apparent genetic associations were possibly mediated by alcohol use. CONCLUSIONS: ALDH2 variants are a credible genetic instrument for Mendelian randomization studies of alcohol use and many attributes of health in Southern Chinese men.
Persistent Identifierhttp://hdl.handle.net/10722/182041
ISSN
2015 Impact Factor: 7.522
2015 SCImago Journal Rankings: 4.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAu Yeung, RSLen_US
dc.contributor.authorJiang, Cen_US
dc.contributor.authorCheng, KKen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorLam, THen_US
dc.contributor.authorLeung, GMen_US
dc.contributor.authorSchooling, CMen_US
dc.date.accessioned2013-04-17T07:19:58Z-
dc.date.available2013-04-17T07:19:58Z-
dc.date.issued2013en_US
dc.identifier.citationInternational Journal of Epidemiology, 2013, v. 42 n. 1, p. 318-328en_US
dc.identifier.issn0300-5771-
dc.identifier.urihttp://hdl.handle.net/10722/182041-
dc.description.abstractBACKGROUND: Mendelian randomization studies provide a means of assessing causal relations without interventions, but require valid genetic instruments. We assessed the credibility of aldehyde dehydrogenase 2 (ALDH2) as a genetic instrument for alcohol use in Southern Chinese men. METHODS: We genotyped the single nucleotide polymorphism rs671 of ALDH2 in 4867 men from the Guangzhou Biobank Cohort Study. We used linear regression to assess the strength of the association of ALDH2 variants with alcohol use, whether ALDH2 variants were independently associated with socio-economic position or other potential confounders and whether associations of ALDH2 variants with cardiovascular risk factors (systolic and diastolic blood pressure, HDL- and LDL-cholesterol, fasting glucose), triglycerides, body mass index, self reported cardiovascular disease, self-reported ischaemic heart disease, cognitive function (delayed 10-word recall and Mini Mental State Examination score) and liver function (alanine transaminase and aspartate transaminase) were fully mediated by alcohol use. RESULTS: The minor allele frequency (A) of ALDH2 was 0.29. The F statistic for ALDH2 variants was 75.0, suggesting that substantial weak instrument bias is unlikely. ALDH2 variants were not associated with socio-economic position, smoking or physical activity. ALDH2 variants were only associated with diastolic blood pressure and HDL-cholesterol, but these genetic associations with blood pressure and HDL-cholesterol were attenuated after adjusting for alcohol use, suggesting the apparent genetic associations were possibly mediated by alcohol use. CONCLUSIONS: ALDH2 variants are a credible genetic instrument for Mendelian randomization studies of alcohol use and many attributes of health in Southern Chinese men.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/-
dc.relation.ispartofInternational Journal of Epidemiologyen_US
dc.subject.meshAlcohol Drinking - genetics-
dc.subject.meshAldehyde Dehydrogenase - genetics - metabolism-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshMendelian Randomization Analysis-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleIs aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men?en_US
dc.typeArticleen_US
dc.identifier.emailAu Yeung, RSL: ayslryan@hku.hken_US
dc.identifier.emailJiang, C: cqjiang@hkucc.hku.hken_US
dc.identifier.emailCheng, KK: chengkk@hkucc.hku.hken_US
dc.identifier.emailZhang, W: zhangws9@hku.hken_US
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_US
dc.identifier.emailLeung, GM: gmleung@hku.hken_US
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hken_US
dc.identifier.authorityLam, TH=rp00326en_US
dc.identifier.authorityLeung, GM=rp00460en_US
dc.identifier.authoritySchooling, CM=rp00504en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ije/dys221-
dc.identifier.pmid23243119-
dc.identifier.scopuseid_2-s2.0-84875594574-
dc.identifier.hkuros213791en_US
dc.identifier.volume42en_US
dc.identifier.issue1en_US
dc.identifier.spage318en_US
dc.identifier.epage328en_US
dc.identifier.isiWOS:000316699300039-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablesml 140428-

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