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Article: Clinical Correlates of Health Preference and Generic Health-related Quality of Life in Patients with Colorectal Neoplasms

TitleClinical Correlates of Health Preference and Generic Health-related Quality of Life in Patients with Colorectal Neoplasms
Authors
Issue Date2013
PublisherPLOS. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS ONE, 2013, v. 8 n. 3, p. e58341 How to Cite?
AbstractBackground: The aims of the study were to assess the health preference and health-related quality of life (HRQOL) in patients with colorectal neoplasms (CRN), and to determine the clinical correlates that significantly influence the HRQOL of patients. Methods: Five hundred and fifty-four CRN patients, inclusive of colorectal polyp or cancer, who attended the colorectal specialist outpatient clinic at Queen Mary Hospital in Hong Kong between October 2009 and July 2010, were included. Patients were interviewed with questionnaires on socio-demographic characteristics, and generic and health preference measures of HRQOL using the SF-12 and SF-6D Health Surveys, respectively. Clinical information on stage of disease at diagnosis, time since diagnosis, primary tumour site was extracted from electronic case record. Mean HRQOL and health preference scores of CRN patients were compared with age-sex matched controls from the Chinese general population using independent t-test. Multiple linear regression analyses were conducted to explore the associations of clinical characteristics with HRQOL measures with the adjustment of socio-demographic characteristics. Results: Cross-sectional data of 515 eligible patients responded to the whole questionnaires were included in outcome analysis. In comparison with age-sex matched normative values, CRN patients reported comparable physical-related HRQOL but better mental-related HRQOL. Amongst CRN patients, time since diagnosis was positively associated with health preference score whilst patients with rectal neoplasms had lower health preference and physical-related HRQOL scores than those with sigmoid neoplasms. Health preference and HRQOL scores were significantly lower in patients with stage IV colorectal cancer than those with other less severe stages, indicating that progressive decline from low-risk polyp to stage IV colorectal cancer was observed in HRQOL scores. Conclusion: In CRN patients, a more advanced stage of disease was associated with worse HRQOL scores. Despite potentially adverse effect of disease on physical-related HRQOL, the mental-related HRQOL of CRN patients were better than that of Chinese general population. © 2013 Wong et al.
Persistent Identifierhttp://hdl.handle.net/10722/181978
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
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DC FieldValueLanguage
dc.contributor.authorWong, CKHen_US
dc.contributor.authorLam, CLKen_US
dc.contributor.authorPoon, TCJen_US
dc.contributor.authorKwong, DLWen_US
dc.date.accessioned2013-04-17T07:15:59Z-
dc.date.available2013-04-17T07:15:59Z-
dc.date.issued2013en_US
dc.identifier.citationPLoS ONE, 2013, v. 8 n. 3, p. e58341en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/181978-
dc.description.abstractBackground: The aims of the study were to assess the health preference and health-related quality of life (HRQOL) in patients with colorectal neoplasms (CRN), and to determine the clinical correlates that significantly influence the HRQOL of patients. Methods: Five hundred and fifty-four CRN patients, inclusive of colorectal polyp or cancer, who attended the colorectal specialist outpatient clinic at Queen Mary Hospital in Hong Kong between October 2009 and July 2010, were included. Patients were interviewed with questionnaires on socio-demographic characteristics, and generic and health preference measures of HRQOL using the SF-12 and SF-6D Health Surveys, respectively. Clinical information on stage of disease at diagnosis, time since diagnosis, primary tumour site was extracted from electronic case record. Mean HRQOL and health preference scores of CRN patients were compared with age-sex matched controls from the Chinese general population using independent t-test. Multiple linear regression analyses were conducted to explore the associations of clinical characteristics with HRQOL measures with the adjustment of socio-demographic characteristics. Results: Cross-sectional data of 515 eligible patients responded to the whole questionnaires were included in outcome analysis. In comparison with age-sex matched normative values, CRN patients reported comparable physical-related HRQOL but better mental-related HRQOL. Amongst CRN patients, time since diagnosis was positively associated with health preference score whilst patients with rectal neoplasms had lower health preference and physical-related HRQOL scores than those with sigmoid neoplasms. Health preference and HRQOL scores were significantly lower in patients with stage IV colorectal cancer than those with other less severe stages, indicating that progressive decline from low-risk polyp to stage IV colorectal cancer was observed in HRQOL scores. Conclusion: In CRN patients, a more advanced stage of disease was associated with worse HRQOL scores. Despite potentially adverse effect of disease on physical-related HRQOL, the mental-related HRQOL of CRN patients were better than that of Chinese general population. © 2013 Wong et al.-
dc.languageengen_US
dc.publisherPLOS. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS ONEen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleClinical Correlates of Health Preference and Generic Health-related Quality of Life in Patients with Colorectal Neoplasmsen_US
dc.typeArticleen_US
dc.identifier.emailWong, CKH: carlosho@hku.hken_US
dc.identifier.emailLam, CLK: clklam@hku.hken_US
dc.identifier.emailPoon, TCJ: tcjensen@hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_US
dc.identifier.authorityLam, CLK=rp00350en_US
dc.identifier.authorityPoon, TCJ=rp01603en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0058341-
dc.identifier.pmid23516465-
dc.identifier.scopuseid_2-s2.0-84874825405-
dc.identifier.hkuros213815en_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.spagee58341en_US
dc.identifier.epagee58341en_US
dc.identifier.isiWOS:000316849200057-
dc.relation.projectA Study on Health-related Quality of Life of patients with Colorectal Neoplasm and Cost-Effectiveness Analysis of Colorectal Cancer Screening in Hong Kong-

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