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Book Chapter: Cadherin-catenin signaling in ovarian cancer progression

TitleCadherin-catenin signaling in ovarian cancer progression
Authors
KeywordsOvaries -- Cancer.
Issue Date2010
PublisherSpringer
Citation
Cadherin-catenin signaling in ovarian cancer progression. In Signal transduction in cancer metastasis, p. 225-253. Dordrecht: Springer, 2010 How to Cite?
AbstractOvarian cancer is a highly metastatic disease and has the highest mortality rate of all gynecological tumors. In contrast to many other types of cancer that metastasize through lymphatics and/or hematogenous routes, ovarian cancer metastasizes by peritoneal dissemination, which relies on the ability of cancer cells to detach from the primary tumor, adhere to, and eventually invade through the peritoneum. This involves dynamic changes in cell-cell adhesion, which is primarily mediated by cell surface receptors known as cadherins. In this review, we will describe the unique profiles of cadherins with their associated signal molecules, catenins, in ovarian cancer and the roles of these adhesion molecules in disease development, tumor cell progression, and the formation of ascites. We will discuss how cadherins perform these functions and their link to a variety of signaling pathways. Finally, we will review the recent findings regarding the potential of cadherins as new therapeutic targets in the treatment of ovarian cancer.
Persistent Identifierhttp://hdl.handle.net/10722/181546
ISBN

 

DC FieldValueLanguage
dc.contributor.authorCheung, WT-
dc.contributor.authorIp, KM-
dc.contributor.authorWong, AST-
dc.date.accessioned2013-03-04T03:30:43Z-
dc.date.available2013-03-04T03:30:43Z-
dc.date.issued2010-
dc.identifier.citationCadherin-catenin signaling in ovarian cancer progression. In Signal transduction in cancer metastasis, p. 225-253. Dordrecht: Springer, 2010-
dc.identifier.isbn9789048195213-
dc.identifier.urihttp://hdl.handle.net/10722/181546-
dc.description.abstractOvarian cancer is a highly metastatic disease and has the highest mortality rate of all gynecological tumors. In contrast to many other types of cancer that metastasize through lymphatics and/or hematogenous routes, ovarian cancer metastasizes by peritoneal dissemination, which relies on the ability of cancer cells to detach from the primary tumor, adhere to, and eventually invade through the peritoneum. This involves dynamic changes in cell-cell adhesion, which is primarily mediated by cell surface receptors known as cadherins. In this review, we will describe the unique profiles of cadherins with their associated signal molecules, catenins, in ovarian cancer and the roles of these adhesion molecules in disease development, tumor cell progression, and the formation of ascites. We will discuss how cadherins perform these functions and their link to a variety of signaling pathways. Finally, we will review the recent findings regarding the potential of cadherins as new therapeutic targets in the treatment of ovarian cancer.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofSignal transduction in cancer metastasis-
dc.subjectOvaries -- Cancer.-
dc.titleCadherin-catenin signaling in ovarian cancer progressionen_US
dc.typeBook_Chapteren_US
dc.identifier.emailWong, AST: awong1@hkucc.hku.hk-
dc.identifier.doi10.1007/978-90-481-9522-0_12-
dc.identifier.hkuros174122-
dc.identifier.hkuros188966-
dc.identifier.hkuros218062-
dc.identifier.spage225-
dc.identifier.epage253-
dc.publisher.placeDordrecht-

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