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Article: No evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women

TitleNo evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese women
Authors
Issue Date2007
Citation
Journal Of Musculoskeletal Neuronal Interactions, 2007, v. 7 n. 2, p. 149-154 How to Cite?
AbstractOsteoporosis is a major health problem, mainly characterized by low bone mineral density (BMD). Osteocalcin (also known as BGP, for bone Gla protein) is a significant biomarker of bone turnover and thus the BGP gene has been considered as an important candidate gene for osteoporosis. A few studies on the relationship between variants of the BGP gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In the present study, we simultaneously tested linkage and/or association of the BGP HindIII polymorphism with BMD in a large cohort of pre-menopausal Chinese women. A total of 1,263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20-45 years. BMDs at the lumbar spine and hip were measured by dual-energy X-ray absorptiometry (DXA). Using the QTDT (quantitative transmission disequilibrium test) program, we did not detect significant evidence of linkage or association between the BGP HindIII polymorphisms and the BMD variation at any skeletal site. Our data do not support the BGP gene having a major effect on BMD variation in pre-menopausal Chinese women.
Persistent Identifierhttp://hdl.handle.net/10722/181212
ISSN
2015 Impact Factor: 1.638
2015 SCImago Journal Rankings: 0.758
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, DKen_US
dc.contributor.authorXu, FXen_US
dc.contributor.authorLiu, MYen_US
dc.contributor.authorChen, XDen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorLiu, YJen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:51Z-
dc.date.available2013-02-21T02:02:51Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Musculoskeletal Neuronal Interactions, 2007, v. 7 n. 2, p. 149-154en_US
dc.identifier.issn1108-7161en_US
dc.identifier.urihttp://hdl.handle.net/10722/181212-
dc.description.abstractOsteoporosis is a major health problem, mainly characterized by low bone mineral density (BMD). Osteocalcin (also known as BGP, for bone Gla protein) is a significant biomarker of bone turnover and thus the BGP gene has been considered as an important candidate gene for osteoporosis. A few studies on the relationship between variants of the BGP gene and BMD variation, via traditional association and/or linkage methods, have yielded conflicting results. In the present study, we simultaneously tested linkage and/or association of the BGP HindIII polymorphism with BMD in a large cohort of pre-menopausal Chinese women. A total of 1,263 subjects from 402 Chinese nuclear families were examined. Each family consists of both parents and at least one daughter aged between 20-45 years. BMDs at the lumbar spine and hip were measured by dual-energy X-ray absorptiometry (DXA). Using the QTDT (quantitative transmission disequilibrium test) program, we did not detect significant evidence of linkage or association between the BGP HindIII polymorphisms and the BMD variation at any skeletal site. Our data do not support the BGP gene having a major effect on BMD variation in pre-menopausal Chinese women.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Musculoskeletal Neuronal Interactionsen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshBone And Bones - Metabolism - Physiopathologyen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markers - Geneticsen_US
dc.subject.meshGenetic Testingen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibrium - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteocalcin - Geneticsen_US
dc.subject.meshOsteoporosis - Ethnology - Genetics - Metabolismen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshSite-Specific Dna-Methyltransferase (Adenine-Specific) - Geneticsen_US
dc.titleNo evidence of association of the osteocalcin gene HindIII polymorphism with bone mineral density in Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17627084-
dc.identifier.scopuseid_2-s2.0-34547917998en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547917998&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue2en_US
dc.identifier.spage149en_US
dc.identifier.epage154en_US
dc.identifier.scopusauthoridJiang, DK=55344961200en_US
dc.identifier.scopusauthoridXu, FX=35072254000en_US
dc.identifier.scopusauthoridLiu, MY=37065486200en_US
dc.identifier.scopusauthoridChen, XD=35487111000en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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