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Article: Alpha2-HS glycoprotein gene is associated with bone size at the hip in Chinese

TitleAlpha2-HS glycoprotein gene is associated with bone size at the hip in Chinese
Authors
Issue Date2005
Citation
Acta Genetica Sinica, 2005, v. 32 n. 11, p. 1128-1135 How to Cite?
AbstractBone size is an important risk factor, independent of bone mineral density (BMD), for osteoporotic fracture. Bone size has a high heritability. A better understanding of genetic factors regulating bone size will have important clinical implications. In this study, we explored the relationship between the alpha2-HS glycoprotein (AHSG) gene and bone size variation at the spine and hip in a Chinese population. The study sample comprised 1 260 subjects from 401 Chinese nuclear families (each including both parents and at least one female child). The Sac I polymorphism inside the exon 7 of the AHSG gene was genotyped and analyzed. This variant represents a nucleotide substitution of C to G at amino acid position 238 resulting in a translation polymorphism of threonine to serine and thus making a potential impact on gene function. We assessed population stratification but did not find significant evidence at any skeletal sites. We found significant association between the AHSG Sac I polymorphism and bone size at the intertrochanteric region (P = 0.019) and the total hip (P = 0.035). The polymorphisms explained 3.74% and 3.16% variations in bone size at the intertrochanteric region and total hip respectively. No significant evidence of linkage was detected, largely due to the limited number of sibpairs in this data set and less informative marker (AHSG Sac I polymorphism) (compared with microsatellite markers) for linkage analysis. Our results suggested that the AHSG gene may contribute to bone size variation at the hip in this Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/181207
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, YJen_US
dc.contributor.authorLiu, XHen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:48Z-
dc.date.available2013-02-21T02:02:48Z-
dc.date.issued2005en_US
dc.identifier.citationActa Genetica Sinica, 2005, v. 32 n. 11, p. 1128-1135en_US
dc.identifier.issn0379-4172en_US
dc.identifier.urihttp://hdl.handle.net/10722/181207-
dc.description.abstractBone size is an important risk factor, independent of bone mineral density (BMD), for osteoporotic fracture. Bone size has a high heritability. A better understanding of genetic factors regulating bone size will have important clinical implications. In this study, we explored the relationship between the alpha2-HS glycoprotein (AHSG) gene and bone size variation at the spine and hip in a Chinese population. The study sample comprised 1 260 subjects from 401 Chinese nuclear families (each including both parents and at least one female child). The Sac I polymorphism inside the exon 7 of the AHSG gene was genotyped and analyzed. This variant represents a nucleotide substitution of C to G at amino acid position 238 resulting in a translation polymorphism of threonine to serine and thus making a potential impact on gene function. We assessed population stratification but did not find significant evidence at any skeletal sites. We found significant association between the AHSG Sac I polymorphism and bone size at the intertrochanteric region (P = 0.019) and the total hip (P = 0.035). The polymorphisms explained 3.74% and 3.16% variations in bone size at the intertrochanteric region and total hip respectively. No significant evidence of linkage was detected, largely due to the limited number of sibpairs in this data set and less informative marker (AHSG Sac I polymorphism) (compared with microsatellite markers) for linkage analysis. Our results suggested that the AHSG gene may contribute to bone size variation at the hip in this Chinese population.en_US
dc.languageengen_US
dc.relation.ispartofActa Genetica Sinicaen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBlood Proteins - Genetics - Physiologyen_US
dc.subject.meshBone And Bones - Anatomy & Histologyen_US
dc.subject.meshChinaen_US
dc.subject.meshHip - Anatomy & Histologyen_US
dc.subject.meshHumansen_US
dc.subject.meshAlpha-2-Hs-Glycoproteinen_US
dc.titleAlpha2-HS glycoprotein gene is associated with bone size at the hip in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16318278-
dc.identifier.scopuseid_2-s2.0-28644431951en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-28644431951&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue11en_US
dc.identifier.spage1128en_US
dc.identifier.epage1135en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridLiu, XH=24577446800en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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