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Article: The (CA) n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families

TitleThe (CA) n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear families
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal Of Human Genetics, 2005, v. 50 n. 6, p. 301-304 How to Cite?
AbstractLow peak bone density (PBD) in adulthood is an important determinant of osteoporotic fracture (OF) in the elderly. The tumor necrosis factor receptor 2 (TNFR2) gene has been considered as an important candidate gene for PBD due to its important role in bone turnover. In this study, we recruited a total of 1,263 subjects from 402 Chinese nuclear families composed of both parents and at least one daughter, and tested the association of the (CA) n polymorphism in intron 4 of the TNFR2 gene with PBD using a more contemporary quantitative transmission disequilibrium test (QTDT). Significant within-family association was detected between the CA16 allele and bone mineral density (BMD) at the lumbar spine with the P-value of 0.005 after permutations, which is still significant after correction for multiple testing. Some evidence of total-family association between the CA16 allele and lumbar spine BMD was found (P=0.021), although the significant level did not reach the empirical threshold (P ≤ 0.007). About 3.14% of lumbar spine BMD variation can be explained by the CA16 allele. In summary, our results suggest that the TNFR2 gene may play an important role in determining lumbar spine BMD variation in Chinese women. © The Japan Society of Human Genetics and Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/181201
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Hen_US
dc.contributor.authorZhao, LJen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorSun, Xen_US
dc.contributor.authorDeng, FYen_US
dc.contributor.authorJiang, DKen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:45Z-
dc.date.available2013-02-21T02:02:45Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Human Genetics, 2005, v. 50 n. 6, p. 301-304en_US
dc.identifier.issn1434-5161en_US
dc.identifier.urihttp://hdl.handle.net/10722/181201-
dc.description.abstractLow peak bone density (PBD) in adulthood is an important determinant of osteoporotic fracture (OF) in the elderly. The tumor necrosis factor receptor 2 (TNFR2) gene has been considered as an important candidate gene for PBD due to its important role in bone turnover. In this study, we recruited a total of 1,263 subjects from 402 Chinese nuclear families composed of both parents and at least one daughter, and tested the association of the (CA) n polymorphism in intron 4 of the TNFR2 gene with PBD using a more contemporary quantitative transmission disequilibrium test (QTDT). Significant within-family association was detected between the CA16 allele and bone mineral density (BMD) at the lumbar spine with the P-value of 0.005 after permutations, which is still significant after correction for multiple testing. Some evidence of total-family association between the CA16 allele and lumbar spine BMD was found (P=0.021), although the significant level did not reach the empirical threshold (P ≤ 0.007). About 3.14% of lumbar spine BMD variation can be explained by the CA16 allele. In summary, our results suggest that the TNFR2 gene may play an important role in determining lumbar spine BMD variation in Chinese women. © The Japan Society of Human Genetics and Springer-Verlag 2005.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.htmlen_US
dc.relation.ispartofJournal of Human Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshElectrophoresisen_US
dc.subject.meshFamilyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshHumansen_US
dc.subject.meshLumbar Vertebrae - Chemistryen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Tumor Necrosis Factor, Type Ii - Geneticsen_US
dc.titleThe (CA) n polymorphism of the TNFR2 gene is associated with peak bone density in Chinese nuclear familiesen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10038-005-0249-5en_US
dc.identifier.pmid15886863-
dc.identifier.scopuseid_2-s2.0-23844483136en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23844483136&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue6en_US
dc.identifier.spage301en_US
dc.identifier.epage304en_US
dc.identifier.isiWOS:000230593100005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridXu, H=7407450019en_US
dc.identifier.scopusauthoridZhao, LJ=7404455505en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridSun, X=36811239200en_US
dc.identifier.scopusauthoridDeng, FY=19640145800en_US
dc.identifier.scopusauthoridJiang, DK=55344961200en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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