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Article: Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women

TitleInteraction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.html
Citation
Acta Pharmacologica Sinica, 2005, v. 26 n. 7, p. 860-864 How to Cite?
AbstractAim: To evaluate whether estrogen receptor α(ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01). Conclusion: We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women. ©2005 CPS and SIMM.
Persistent Identifierhttp://hdl.handle.net/10722/181199
ISSN
2015 Impact Factor: 3.166
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, Hen_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:44Z-
dc.date.available2013-02-21T02:02:44Z-
dc.date.issued2005en_US
dc.identifier.citationActa Pharmacologica Sinica, 2005, v. 26 n. 7, p. 860-864en_US
dc.identifier.issn1671-4083en_US
dc.identifier.urihttp://hdl.handle.net/10722/181199-
dc.description.abstractAim: To evaluate whether estrogen receptor α(ER-α) and vitamin D receptor (VDR) genes are associated with the age at menarche in Chinese women. Methods: A total of 390 pre-menopausal Chinese women were genotyped at the ER-α PvuII, XbaI, and VDR ApaI loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Results: Neither the ER-α gene nor the VDR gene individually had significant effects on the age at menarche in our subjects (P>0.10). However, evidence of interaction effects between the two genes were observed: with the aa genotype at the VDR ApaI locus, subjects with haplotype PX at the ER-α gene had, on average, 6 months later onset of menarche than the non-carriers (P=0.01). Conclusion: We found that neither the ER-α gene or the VDR gene had a significant association with the age at menarche individually. However, potential interaction effects between the two genes were observed in Chinese women. ©2005 CPS and SIMM.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/aps/index.htmlen_US
dc.relation.ispartofActa Pharmacologica Sinicaen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChinaen_US
dc.subject.meshEstrogen Receptor Alpha - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMenarche - Geneticsen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshPremenopauseen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.titleInteraction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1745-7254.2005.00122.xen_US
dc.identifier.pmid15960894-
dc.identifier.scopuseid_2-s2.0-22144470179en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22144470179&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue7en_US
dc.identifier.spage860en_US
dc.identifier.epage864en_US
dc.identifier.isiWOS:000230442400013-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXu, H=7407450019en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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