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Article: Genetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population

TitleGenetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese population
Authors
Issue Date2005
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal Of Bone And Mineral Metabolism, 2005, v. 23 n. 2, p. 181-185 How to Cite?
AbstractBone mineral density (BMD) is a significant determinant of risk for osteoporosis. Genetic factors are known to account for a major proportion of variation of BMD in Caucasians. However, the degree of genetic determination of BMD in Chinese populations has seldom been investigated. The aim of our study was to investigate the magnitude of the genetic determination of BMD at the spine and hip, and their genetic covariation, in a population of Shanghai city in P. R. China. The subjects consisted of 44 full-sib pairs of females aged 19-43 years, 186 mother-daughter pairs, and 270 nuclear families. For BMD at the spine and hip, the values for narrow-sense heritability h 2 (±SE) were 0.72 ± 0.14 and 0.87 ± 0.14, respectively, when estimated by full-sib pairs, and 0.44 ± 0.07 and 0.77 ± 0.07, respectively, when estimated by mother-daughter pairs. There was a significant genetic correlation r g (±SE) of BMD between the spine and hip, of 0.97 ± 0.01 and 0.76 ± 0.04, respectively, when estimated by full-sib pairs and mother-daughter pairs. The common household impact on BMD in our study was negligible according to the statistical estimate. We conclude that genetic factors play a major role in the determination of the variation and covariation of BMD at the spine and hip in our Chinese sample. © Springer-Verlag Tokyo 2005.
Persistent Identifierhttp://hdl.handle.net/10722/181193
ISSN
2015 Impact Factor: 2.312
2015 SCImago Journal Rankings: 0.775
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJian, WXen_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorLiu, XHen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:40Z-
dc.date.available2013-02-21T02:02:40Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Bone And Mineral Metabolism, 2005, v. 23 n. 2, p. 181-185en_US
dc.identifier.issn0914-8779en_US
dc.identifier.urihttp://hdl.handle.net/10722/181193-
dc.description.abstractBone mineral density (BMD) is a significant determinant of risk for osteoporosis. Genetic factors are known to account for a major proportion of variation of BMD in Caucasians. However, the degree of genetic determination of BMD in Chinese populations has seldom been investigated. The aim of our study was to investigate the magnitude of the genetic determination of BMD at the spine and hip, and their genetic covariation, in a population of Shanghai city in P. R. China. The subjects consisted of 44 full-sib pairs of females aged 19-43 years, 186 mother-daughter pairs, and 270 nuclear families. For BMD at the spine and hip, the values for narrow-sense heritability h 2 (±SE) were 0.72 ± 0.14 and 0.87 ± 0.14, respectively, when estimated by full-sib pairs, and 0.44 ± 0.07 and 0.77 ± 0.07, respectively, when estimated by mother-daughter pairs. There was a significant genetic correlation r g (±SE) of BMD between the spine and hip, of 0.97 ± 0.01 and 0.76 ± 0.04, respectively, when estimated by full-sib pairs and mother-daughter pairs. The common household impact on BMD in our study was negligible according to the statistical estimate. We conclude that genetic factors play a major role in the determination of the variation and covariation of BMD at the spine and hip in our Chinese sample. © Springer-Verlag Tokyo 2005.en_US
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htmen_US
dc.relation.ispartofJournal of Bone and Mineral Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChinaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Variation - Physiologyen_US
dc.subject.meshHip - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshSiblingsen_US
dc.subject.meshSpine - Physiologyen_US
dc.titleGenetic determination of variation and covariation of bone mineral density at the hip and spine in a Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00774-004-0558-3en_US
dc.identifier.pmid15750698-
dc.identifier.scopuseid_2-s2.0-17844402712en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844402712&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue2en_US
dc.identifier.spage181en_US
dc.identifier.epage185en_US
dc.identifier.isiWOS:000227445500013-
dc.publisher.placeJapanen_US
dc.identifier.scopusauthoridJian, WX=7005765053en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridLiu, XH=24577446800en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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