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Article: No evidence for linkage and/or association of human Alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear families

TitleNo evidence for linkage and/or association of human Alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear families
Authors
Issue Date2003
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223
Citation
Calcified Tissue International, 2003, v. 73 n. 3, p. 244-250 How to Cite?
AbstractOsteoporosis is an important health problem in the world. Alpha2-HS glycoprotein (AHSG) is involved in bone formation and metabolism and has been considered as an important candidate gene for osteoporosis. In this study, we simultaneously tested linkage and/or association of the AHSG gene with the variation of bone mineral density (BMD), an important risk factor for osteoporosis. A sample of 1,260 subjects from 401 Chinese nuclear families (including both parents and their daughters) were studied. The daughters' ages ranged from 20 to 45 years. All the subjects were genotyped by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) at polymorphic Sac I site inside the exon 7 of the AHSG gene. This polymorphism involves a nucleotide substitution of C to G at the middle nucleotide of the codon at amino acid position 238, resulting in the replacement of threonine (ACC) with serine (AGC). BMD was measured at the lumbar spine and hip region by dual-energy X-ray absorptiometry (DXA). Using the QTDT (quantitative trait transmission disequilibrium test), we found no significant results for association or linkage between the AHSG gene and BMD variation at the spine or hip. Our data provided no evidence to support the AHSG gene as a quantitative trait locus (QTL) for the BMD variation in a Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/181188
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, XHen_US
dc.contributor.authorLiu, YJen_US
dc.contributor.authorJiang, DKen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorLi, MXen_US
dc.contributor.authorQin, YJen_US
dc.contributor.authorJian, WXen_US
dc.contributor.authorZhou, Qen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2013-02-21T02:02:36Z-
dc.date.available2013-02-21T02:02:36Z-
dc.date.issued2003en_US
dc.identifier.citationCalcified Tissue International, 2003, v. 73 n. 3, p. 244-250en_US
dc.identifier.issn0171-967Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/181188-
dc.description.abstractOsteoporosis is an important health problem in the world. Alpha2-HS glycoprotein (AHSG) is involved in bone formation and metabolism and has been considered as an important candidate gene for osteoporosis. In this study, we simultaneously tested linkage and/or association of the AHSG gene with the variation of bone mineral density (BMD), an important risk factor for osteoporosis. A sample of 1,260 subjects from 401 Chinese nuclear families (including both parents and their daughters) were studied. The daughters' ages ranged from 20 to 45 years. All the subjects were genotyped by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) at polymorphic Sac I site inside the exon 7 of the AHSG gene. This polymorphism involves a nucleotide substitution of C to G at the middle nucleotide of the codon at amino acid position 238, resulting in the replacement of threonine (ACC) with serine (AGC). BMD was measured at the lumbar spine and hip region by dual-energy X-ray absorptiometry (DXA). Using the QTDT (quantitative trait transmission disequilibrium test), we found no significant results for association or linkage between the AHSG gene and BMD variation at the spine or hip. Our data provided no evidence to support the AHSG gene as a quantitative trait locus (QTL) for the BMD variation in a Chinese population.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223en_US
dc.relation.ispartofCalcified Tissue Internationalen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBlood Proteins - Geneticsen_US
dc.subject.meshBone Densityen_US
dc.subject.meshBone And Bones - Metabolism - Radiographyen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Variation - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNuclear Familyen_US
dc.subject.meshAlpha-2-Hs-Glycoproteinen_US
dc.titleNo evidence for linkage and/or association of human Alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear familiesen_US
dc.typeArticleen_US
dc.identifier.emailLi, MX: mxli@hku.hken_US
dc.identifier.authorityLi, MX=rp01722en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00223-002-0005-1en_US
dc.identifier.pmid14667137-
dc.identifier.scopuseid_2-s2.0-0141523153en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141523153&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue3en_US
dc.identifier.spage244en_US
dc.identifier.epage250en_US
dc.identifier.isiWOS:000185296400007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, XH=24577446800en_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridJiang, DK=55344961200en_US
dc.identifier.scopusauthoridLi, YM=7502098054en_US
dc.identifier.scopusauthoridLi, MX=17135391100en_US
dc.identifier.scopusauthoridQin, YJ=7403100918en_US
dc.identifier.scopusauthoridJian, WX=7005765053en_US
dc.identifier.scopusauthoridZhou, Q=7402700311en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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