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Article: EYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear

TitleEYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner ear
Authors
Wong, EYMAhmed, MXu, PX
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/heares
Citation
Hearing Research, 2013, v. 297, p. 13-19 How to Cite?
DOI: http://dx.doi.org/10.1016/j.heares.2012.09.009
AbstractThe phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.
Persistent Identifierhttp://hdl.handle.net/10722/181185
ISSN
0378-5955
2021 Impact Factor: 3.672
2020 SCImago Journal Rankings: 1.389
ISI Accession Number ID
WOS:000317706700003

 

DC FieldValueLanguage
dc.contributor.authorWong, EYMen_US
dc.contributor.authorAhmed, Men_US
dc.contributor.authorXu, PXen_US
dc.date.accessioned2013-02-21T02:02:23Z-
dc.date.available2013-02-21T02:02:23Z-
dc.date.issued2013en_US
dc.identifier.citationHearing Research, 2013, v. 297, p. 13-19en_US
dc.identifier.issn0378-5955en_US
dc.identifier.urihttp://hdl.handle.net/10722/181185-
dc.description.abstractThe phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/hearesen_US
dc.relation.ispartofHearing Researchen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Hearing Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Hearing Research, [VOL 297, 2013] DOI 10.1016/j.heares.2012.09.009-
dc.titleEYA1-SIX1 complex in neurosensory cell fate induction in the mammalian inner earen_US
dc.typeArticleen_US
dc.identifier.emailWong, EYM: elainewg@hku.hken_US
dc.identifier.authorityWong, EYM=rp01718en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.heares.2012.09.009en_US
dc.identifier.pmid23104013-
dc.identifier.scopuseid_2-s2.0-84875380020en_US
dc.identifier.hkuros270309-
dc.identifier.isiWOS:000317706700003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridWong, EYM=36719382700en_US
dc.identifier.scopusauthoridAhmed, M=55445723800en_US
dc.identifier.scopusauthoridXu, PX=7202215527en_US
dc.identifier.issnl0378-5955-

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