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Article: Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

TitleHarnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis
Authors
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ni
Citation
Nature Immunology, 2012, v. 13 n. 1, p. 86-94 How to Cite?
AbstractCell fate depends on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome-remodeling and histone-deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid lineage-determining proteins. Ikaros, an integral component of the NuRD complex in lymphocytes, tethered this complex to active genes encoding molecules involved in lymphoid differentiation. Loss of Ikaros DNA-binding activity caused a local increase in chromatin remodeling and histone deacetylation and suppression of lymphoid cell-specific gene expression. Without Ikaros, the NuRD complex also redistributed to transcriptionally poised genes that were not targets of Ikaros (encoding molecules involved in proliferation and metabolism), which induced their reactivation. Thus, release of NuRD from Ikaros regulation blocks lymphocyte maturation and mediates progression to a leukemic state by engaging functionally opposing epigenetic and genetic networks. © 2012 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/180750
ISSN
2015 Impact Factor: 19.381
2015 SCImago Journal Rankings: 13.253
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jen_US
dc.contributor.authorJackson, AFen_US
dc.contributor.authorNaito, Ten_US
dc.contributor.authorDose, Men_US
dc.contributor.authorSeavitt, Jen_US
dc.contributor.authorLiu, Fen_US
dc.contributor.authorHeller, EJen_US
dc.contributor.authorKashiwagi, Men_US
dc.contributor.authorYoshida, Ten_US
dc.contributor.authorGounari, Fen_US
dc.contributor.authorPetrie, HTen_US
dc.contributor.authorGeorgopoulos, Ken_US
dc.date.accessioned2013-01-28T01:42:16Z-
dc.date.available2013-01-28T01:42:16Z-
dc.date.issued2012en_US
dc.identifier.citationNature Immunology, 2012, v. 13 n. 1, p. 86-94en_US
dc.identifier.issn1529-2908en_US
dc.identifier.urihttp://hdl.handle.net/10722/180750-
dc.description.abstractCell fate depends on the interplay between chromatin regulators and transcription factors. Here we show that activity of the Mi-2β nucleosome-remodeling and histone-deacetylase (NuRD) complex was controlled by the Ikaros family of lymphoid lineage-determining proteins. Ikaros, an integral component of the NuRD complex in lymphocytes, tethered this complex to active genes encoding molecules involved in lymphoid differentiation. Loss of Ikaros DNA-binding activity caused a local increase in chromatin remodeling and histone deacetylation and suppression of lymphoid cell-specific gene expression. Without Ikaros, the NuRD complex also redistributed to transcriptionally poised genes that were not targets of Ikaros (encoding molecules involved in proliferation and metabolism), which induced their reactivation. Thus, release of NuRD from Ikaros regulation blocks lymphocyte maturation and mediates progression to a leukemic state by engaging functionally opposing epigenetic and genetic networks. © 2012 Nature America, Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nien_US
dc.relation.ispartofNature Immunologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCell Differentiation - Geneticsen_US
dc.subject.meshChromatin Assembly And Disassemblyen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Regulatory Networksen_US
dc.subject.meshIkaros Transcription Factor - Genetics - Metabolismen_US
dc.subject.meshLeukemia - Geneticsen_US
dc.subject.meshLymphocytes - Enzymology - Immunologyen_US
dc.subject.meshMi-2 Nucleosome Remodeling And Deacetylase Complex - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshNucleotide Motifsen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshThymocytes - Metabolismen_US
dc.titleHarnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesisen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ni.2150en_US
dc.identifier.pmid22080921-
dc.identifier.scopuseid_2-s2.0-83855160775en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83855160775&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage86en_US
dc.identifier.epage94en_US
dc.identifier.isiWOS:000298412800015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridJackson, AF=7402785468en_US
dc.identifier.scopusauthoridNaito, T=7202253732en_US
dc.identifier.scopusauthoridDose, M=8548572200en_US
dc.identifier.scopusauthoridSeavitt, J=7801489516en_US
dc.identifier.scopusauthoridLiu, F=36067802500en_US
dc.identifier.scopusauthoridHeller, EJ=7103003041en_US
dc.identifier.scopusauthoridKashiwagi, M=36892980600en_US
dc.identifier.scopusauthoridYoshida, T=7501316871en_US
dc.identifier.scopusauthoridGounari, F=6603925154en_US
dc.identifier.scopusauthoridPetrie, HT=7005577894en_US
dc.identifier.scopusauthoridGeorgopoulos, K=7006021598en_US

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