File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1126/science.1190831
- Scopus: eid_2-s2.0-77955285002
- PMID: 20616234
- WOS: WOS:000280602700039
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Sex-specific parent-of-origin allelic expression in the mouse brain
Title | Sex-specific parent-of-origin allelic expression in the mouse brain |
---|---|
Authors | |
Issue Date | 2010 |
Publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org |
Citation | Science, 2010, v. 329 n. 5992, p. 682-685 How to Cite? |
Abstract | Genomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease. |
Persistent Identifier | http://hdl.handle.net/10722/180740 |
ISSN | 2021 Impact Factor: 63.714 2020 SCImago Journal Rankings: 12.556 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gregg, C | en_US |
dc.contributor.author | Zhang, J | en_US |
dc.contributor.author | Butler, JE | en_US |
dc.contributor.author | Haig, D | en_US |
dc.contributor.author | Dulac, C | en_US |
dc.date.accessioned | 2013-01-28T01:42:09Z | - |
dc.date.available | 2013-01-28T01:42:09Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Science, 2010, v. 329 n. 5992, p. 682-685 | en_US |
dc.identifier.issn | 0036-8075 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180740 | - |
dc.description.abstract | Genomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org | en_US |
dc.relation.ispartof | Science | en_US |
dc.subject.mesh | Alleles | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Crosses, Genetic | en_US |
dc.subject.mesh | Dioxygenases | en_US |
dc.subject.mesh | Epigenesis, Genetic | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gene Expression Profiling | en_US |
dc.subject.mesh | Genes, X-Linked | en_US |
dc.subject.mesh | Genomic Imprinting | en_US |
dc.subject.mesh | Glutamic Acid - Metabolism | en_US |
dc.subject.mesh | Interleukin-18 - Genetics | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, Inbred C57bl | en_US |
dc.subject.mesh | Mice, Transgenic | en_US |
dc.subject.mesh | Mitochondrial Proteins - Genetics | en_US |
dc.subject.mesh | Neurons - Metabolism | en_US |
dc.subject.mesh | Oxygenases - Genetics | en_US |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_US |
dc.subject.mesh | Prefrontal Cortex - Cytology - Metabolism | en_US |
dc.subject.mesh | Preoptic Area - Cytology - Metabolism | en_US |
dc.subject.mesh | Ribosomal Proteins - Genetics | en_US |
dc.subject.mesh | Sex Characteristics | en_US |
dc.subject.mesh | Succinate Dehydrogenase - Genetics | en_US |
dc.subject.mesh | X Chromosome Inactivation | en_US |
dc.title | Sex-specific parent-of-origin allelic expression in the mouse brain | en_US |
dc.type | Article | en_US |
dc.identifier.email | Zhang, J: jzhang1@hku.hk | en_US |
dc.identifier.authority | Zhang, J=rp01713 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1126/science.1190831 | en_US |
dc.identifier.pmid | 20616234 | - |
dc.identifier.scopus | eid_2-s2.0-77955285002 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77955285002&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 329 | en_US |
dc.identifier.issue | 5992 | en_US |
dc.identifier.spage | 682 | en_US |
dc.identifier.epage | 685 | en_US |
dc.identifier.isi | WOS:000280602700039 | - |
dc.publisher.place | United States | en_US |
dc.identifier.f1000 | 4979957 | - |
dc.identifier.scopusauthorid | Gregg, C=34770701300 | en_US |
dc.identifier.scopusauthorid | Zhang, J=22137260600 | en_US |
dc.identifier.scopusauthorid | Butler, JE=36571424800 | en_US |
dc.identifier.scopusauthorid | Haig, D=7005499789 | en_US |
dc.identifier.scopusauthorid | Dulac, C=7004206541 | en_US |
dc.identifier.issnl | 0036-8075 | - |