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Article: Sex-specific parent-of-origin allelic expression in the mouse brain

TitleSex-specific parent-of-origin allelic expression in the mouse brain
Authors
Issue Date2010
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2010, v. 329 n. 5992, p. 682-685 How to Cite?
AbstractGenomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease.
Persistent Identifierhttp://hdl.handle.net/10722/180740
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGregg, Cen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorButler, JEen_US
dc.contributor.authorHaig, Den_US
dc.contributor.authorDulac, Cen_US
dc.date.accessioned2013-01-28T01:42:09Z-
dc.date.available2013-01-28T01:42:09Z-
dc.date.issued2010en_US
dc.identifier.citationScience, 2010, v. 329 n. 5992, p. 682-685en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/180740-
dc.description.abstractGenomic imprinting results in preferential gene expression from paternally versus maternally inherited chromosomes. We used a genome-wide approach to uncover sex-specific parent-of-origin allelic effects in the adult mouse brain. Our study identified preferential selection of the maternally inherited X chromosome in glutamatergic neurons of the female cortex. Moreover, analysis of the cortex and hypothalamus identified 347 autosomal genes with sex-specific imprinting features. In the hypothalamus, sex-specific imprinted genes were mostly found in females, which suggests parental influence over the hypothalamic function of daughters. We show that interleukin-18, a gene linked to diseases with sex-specific prevalence, is subject to complex, regional, and sex-specific parental effects in the brain. Parent-of-origin effects thus provide new avenues for investigation of sexual dimorphism in brain function and disease.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshAllelesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCrosses, Geneticen_US
dc.subject.meshDioxygenasesen_US
dc.subject.meshEpigenesis, Geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGenes, X-Linkeden_US
dc.subject.meshGenomic Imprintingen_US
dc.subject.meshGlutamic Acid - Metabolismen_US
dc.subject.meshInterleukin-18 - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshMitochondrial Proteins - Geneticsen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshOxygenases - Geneticsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPrefrontal Cortex - Cytology - Metabolismen_US
dc.subject.meshPreoptic Area - Cytology - Metabolismen_US
dc.subject.meshRibosomal Proteins - Geneticsen_US
dc.subject.meshSex Characteristicsen_US
dc.subject.meshSuccinate Dehydrogenase - Geneticsen_US
dc.subject.meshX Chromosome Inactivationen_US
dc.titleSex-specific parent-of-origin allelic expression in the mouse brainen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1190831en_US
dc.identifier.pmid20616234-
dc.identifier.scopuseid_2-s2.0-77955285002en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955285002&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume329en_US
dc.identifier.issue5992en_US
dc.identifier.spage682en_US
dc.identifier.epage685en_US
dc.identifier.isiWOS:000280602700039-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10004979957-
dc.identifier.scopusauthoridGregg, C=34770701300en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridButler, JE=36571424800en_US
dc.identifier.scopusauthoridHaig, D=7005499789en_US
dc.identifier.scopusauthoridDulac, C=7004206541en_US

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