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Article: Genome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells

TitleGenome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cells
Authors
Issue Date2009
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/immuni
Citation
Immunity, 2009, v. 30 n. 4, p. 493-507 How to Cite?
AbstractThe mechanisms regulating lineage potential during early hematopoiesis were investigated. First, a cascade of lineage-affiliated gene expression signatures, primed in hematopoietic stem cells (HSCs) and differentially propagated in lineage-restricted progenitors, was identified. Lymphoid transcripts were primed as early as the HSC, together with myeloid and erythroid transcripts. Although this multilineage priming was resolved upon subsequent lineage restrictions, an unexpected cosegregation of lymphoid and myeloid gene expression and potential past a nominal myeloid restriction point was identified. Finally, we demonstrated that whereas the zinc finger DNA-binding factor Ikaros was required for induction of lymphoid lineage priming in the HSC, it was also necessary for repression of genetic programs compatible with self-renewal and multipotency downstream of the HSC. Taken together, our studies provide new insight into the priming and restriction of lineage potentials during early hematopoiesis and identify Ikaros as a key bivalent regulator of this process. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/180734
ISSN
2015 Impact Factor: 24.082
2015 SCImago Journal Rankings: 16.215
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, SYMen_US
dc.contributor.authorYoshida, Ten_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorGeorgopoulos, Ken_US
dc.date.accessioned2013-01-28T01:42:06Z-
dc.date.available2013-01-28T01:42:06Z-
dc.date.issued2009en_US
dc.identifier.citationImmunity, 2009, v. 30 n. 4, p. 493-507en_US
dc.identifier.issn1074-7613en_US
dc.identifier.urihttp://hdl.handle.net/10722/180734-
dc.description.abstractThe mechanisms regulating lineage potential during early hematopoiesis were investigated. First, a cascade of lineage-affiliated gene expression signatures, primed in hematopoietic stem cells (HSCs) and differentially propagated in lineage-restricted progenitors, was identified. Lymphoid transcripts were primed as early as the HSC, together with myeloid and erythroid transcripts. Although this multilineage priming was resolved upon subsequent lineage restrictions, an unexpected cosegregation of lymphoid and myeloid gene expression and potential past a nominal myeloid restriction point was identified. Finally, we demonstrated that whereas the zinc finger DNA-binding factor Ikaros was required for induction of lymphoid lineage priming in the HSC, it was also necessary for repression of genetic programs compatible with self-renewal and multipotency downstream of the HSC. Taken together, our studies provide new insight into the priming and restriction of lineage potentials during early hematopoiesis and identify Ikaros as a key bivalent regulator of this process. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/immunien_US
dc.relation.ispartofImmunityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineageen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGene Regulatory Networksen_US
dc.subject.meshGenomeen_US
dc.subject.meshHematopoiesis - Immunologyen_US
dc.subject.meshHematopoietic Stem Cells - Immunologyen_US
dc.subject.meshIkaros Transcription Factor - Metabolismen_US
dc.subject.meshLymphocytes - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshMice, Transgenicen_US
dc.titleGenome-wide Lineage-Specific Transcriptional Networks Underscore Ikaros-Dependent Lymphoid Priming in Hematopoietic Stem Cellsen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.immuni.2009.01.014en_US
dc.identifier.pmid19345118-
dc.identifier.scopuseid_2-s2.0-64049102658en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64049102658&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume30en_US
dc.identifier.issue4en_US
dc.identifier.spage493en_US
dc.identifier.epage507en_US
dc.identifier.isiWOS:000265319000007-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001159224-
dc.identifier.scopusauthoridNg, SYM=16028784500en_US
dc.identifier.scopusauthoridYoshida, T=7501316871en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridGeorgopoulos, K=7006021598en_US

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