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Article: Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn

TitleReduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn
Authors
Issue Date2008
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Citation
International Journal Of Molecular Medicine, 2008, v. 21 n. 2, p. 201-208 How to Cite?
AbstractUsing a mouse model of burn trauma, we tested the hypothesis that severe bum trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to assess the rate of ATP synthesis, and characterized the concomitant gene expression patterns in skeletal muscle in burned (30% TBSA) versus control mice. Our NMR results showed a significantly reduced rate of ATP synthesis and were complemented by genomic results showing downregulation of the ATP synthase mitochondrial F 1F 0 complex and PGC-1β gene expression. Our findings suggest that inflammation and muscle atrophy in burns are due to a reduced ATP synthesis rate that may be regulated upstream by PGC-1β. These findings implicate mitochondrial dysfunction in distal skeletal muscle following burn injury. That PGC-1β is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1β.
Persistent Identifierhttp://hdl.handle.net/10722/180730
ISSN
2015 Impact Factor: 2.348
2015 SCImago Journal Rankings: 0.868
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAria Tzika, Aen_US
dc.contributor.authorMintzopoulos, Den_US
dc.contributor.authorPadfield, Ken_US
dc.contributor.authorWilhelmy, Jen_US
dc.contributor.authorMindrinos, MNen_US
dc.contributor.authorYu, Hen_US
dc.contributor.authorCao, Hen_US
dc.contributor.authorZhang, Qen_US
dc.contributor.authorAstrakas, LGen_US
dc.contributor.authorZhang, Jen_US
dc.contributor.authorYu, YMen_US
dc.contributor.authorRahme, LGen_US
dc.contributor.authorTompkins, RGen_US
dc.date.accessioned2013-01-28T01:42:05Z-
dc.date.available2013-01-28T01:42:05Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Molecular Medicine, 2008, v. 21 n. 2, p. 201-208en_US
dc.identifier.issn1107-3756en_US
dc.identifier.urihttp://hdl.handle.net/10722/180730-
dc.description.abstractUsing a mouse model of burn trauma, we tested the hypothesis that severe bum trauma corresponding to 30% of total body surface area (TBSA) causes reduction in adenosine triphosphate (ATP) synthesis in distal skeletal muscle. We employed in vivo 31P nuclear magnetic resonance (NMR) in intact mice to assess the rate of ATP synthesis, and characterized the concomitant gene expression patterns in skeletal muscle in burned (30% TBSA) versus control mice. Our NMR results showed a significantly reduced rate of ATP synthesis and were complemented by genomic results showing downregulation of the ATP synthase mitochondrial F 1F 0 complex and PGC-1β gene expression. Our findings suggest that inflammation and muscle atrophy in burns are due to a reduced ATP synthesis rate that may be regulated upstream by PGC-1β. These findings implicate mitochondrial dysfunction in distal skeletal muscle following burn injury. That PGC-1β is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1β.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htmen_US
dc.relation.ispartofInternational Journal of Molecular Medicineen_US
dc.subject.meshAdenosine Triphosphate - Biosynthesisen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Surface Areaen_US
dc.subject.meshBurns - Genetics - Metabolismen_US
dc.subject.meshDown-Regulation - Geneticsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshMuscle, Skeletal - Metabolism - Pathologyen_US
dc.subject.meshOxidative Phosphorylationen_US
dc.subject.meshPhosphorus Isotopesen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshTrans-Activators - Genetics - Metabolismen_US
dc.titleReduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burnen_US
dc.typeArticleen_US
dc.identifier.emailZhang, J: jzhang1@hku.hken_US
dc.identifier.authorityZhang, J=rp01713en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18204786-
dc.identifier.scopuseid_2-s2.0-38949103707en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38949103707&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue2en_US
dc.identifier.spage201en_US
dc.identifier.epage208en_US
dc.identifier.isiWOS:000252621300008-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridAria Tzika, A=55281755100en_US
dc.identifier.scopusauthoridMintzopoulos, D=16070342600en_US
dc.identifier.scopusauthoridPadfield, K=8558801400en_US
dc.identifier.scopusauthoridWilhelmy, J=6602853926en_US
dc.identifier.scopusauthoridMindrinos, MN=6603048545en_US
dc.identifier.scopusauthoridYu, H=23491121800en_US
dc.identifier.scopusauthoridCao, H=36829765800en_US
dc.identifier.scopusauthoridZhang, Q=8558801500en_US
dc.identifier.scopusauthoridAstrakas, LG=6603155897en_US
dc.identifier.scopusauthoridZhang, J=22137260600en_US
dc.identifier.scopusauthoridYu, YM=36161516900en_US
dc.identifier.scopusauthoridRahme, LG=6603919311en_US
dc.identifier.scopusauthoridTompkins, RG=7101805272en_US

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