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Article: Comparison of nuchal and detailed morphology ultrasound examinations in early pregnancy for fetal structural abnormality screening: A randomized controlled trial

TitleComparison of nuchal and detailed morphology ultrasound examinations in early pregnancy for fetal structural abnormality screening: A randomized controlled trial
Authors
Issue Date2008
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 2008, v. 31 n. 2, p. 136-146 How to Cite?
AbstractObjective: To compare the effectiveness of a nuchal scan at 10 to 14 + 6 weeks and a detailed morphology scan at 12 to 14 + 6 weeks in screening for fetal structural abnormalities. Methods: From March 2001 to November 2004, 8811 pregnant women were randomized into either the control group (10 to 14 + 6-week nuchal scan followed by routine 16-23-week scan) or the study group (10 to 14 + 6-week nuchal scan and 12 to 14 + 6-week detailed scan followed by routine 16-23-week scan). Results: We analyzed 7642 cases of singleton pregnancies with viable fetuses at first-trimester ultrasound examination and with known pregnancy outcome. In the control group, the detection rate of structural abnormalities in the first trimester was 32.8% (21/64; 95% CI, 21.6-45.7%) and the overall detection rate was 64.1% (41/64; 95% CI, 51.1-75.7%). In the study group, the detection rate in the first trimester was 47.6% (30/63; 95% CI, 34.9-60.6) and the overall detection rate was 66.7% (42/63; 95% CI, 53.7-78.0%). The overall detection rate in the control group did not differ significantly from that in the study group (P >0.05). Conclusions: When the nuchal scan is offered, a basic anatomical survey can be done in conjunction with nuchal translucency thickness measurement. A detailed ultrasound examination at this early gestational age may not be superior to the nuchal scan in screening for fetal abnormalities in the low-risk population. Though a wide range of abnormalities can be detected at 10 to 14 + 6 weeks, the routine 16-23-week scan cannot be abandoned. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180691
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Men_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, RYKen_US
dc.contributor.authorChan, BCPen_US
dc.contributor.authorWong, SFen_US
dc.contributor.authorTse, LHYen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:08Z-
dc.date.available2013-01-28T01:41:08Z-
dc.date.issued2008en_US
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 2008, v. 31 n. 2, p. 136-146en_US
dc.identifier.issn0960-7692en_US
dc.identifier.urihttp://hdl.handle.net/10722/180691-
dc.description.abstractObjective: To compare the effectiveness of a nuchal scan at 10 to 14 + 6 weeks and a detailed morphology scan at 12 to 14 + 6 weeks in screening for fetal structural abnormalities. Methods: From March 2001 to November 2004, 8811 pregnant women were randomized into either the control group (10 to 14 + 6-week nuchal scan followed by routine 16-23-week scan) or the study group (10 to 14 + 6-week nuchal scan and 12 to 14 + 6-week detailed scan followed by routine 16-23-week scan). Results: We analyzed 7642 cases of singleton pregnancies with viable fetuses at first-trimester ultrasound examination and with known pregnancy outcome. In the control group, the detection rate of structural abnormalities in the first trimester was 32.8% (21/64; 95% CI, 21.6-45.7%) and the overall detection rate was 64.1% (41/64; 95% CI, 51.1-75.7%). In the study group, the detection rate in the first trimester was 47.6% (30/63; 95% CI, 34.9-60.6) and the overall detection rate was 66.7% (42/63; 95% CI, 53.7-78.0%). The overall detection rate in the control group did not differ significantly from that in the study group (P >0.05). Conclusions: When the nuchal scan is offered, a basic anatomical survey can be done in conjunction with nuchal translucency thickness measurement. A detailed ultrasound examination at this early gestational age may not be superior to the nuchal scan in screening for fetal abnormalities in the low-risk population. Though a wide range of abnormalities can be detected at 10 to 14 + 6 weeks, the routine 16-23-week scan cannot be abandoned. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_US
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_US
dc.subject.meshAdulten_US
dc.subject.meshDown Syndrome - Ultrasonographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetus - Abnormalitiesen_US
dc.subject.meshHumansen_US
dc.subject.meshNuchal Translucency Measurementen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.titleComparison of nuchal and detailed morphology ultrasound examinations in early pregnancy for fetal structural abnormality screening: A randomized controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/uog.5232en_US
dc.identifier.pmid18254132-
dc.identifier.scopuseid_2-s2.0-54549113274en_US
dc.identifier.hkuros164969-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54549113274&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue2en_US
dc.identifier.spage136en_US
dc.identifier.epage146en_US
dc.identifier.isiWOS:000253511300004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, M=26028797000en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, RYK=7202300287en_US
dc.identifier.scopusauthoridChan, BCP=7201530637en_US
dc.identifier.scopusauthoridWong, SF=7404590679en_US
dc.identifier.scopusauthoridTse, LHY=36891045800en_US
dc.identifier.scopusauthoridTang, MHY=35362943900en_US

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