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Article: A prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening result

TitleA prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening result
Authors
Issue Date2008
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/FDT
Citation
Fetal Diagnosis And Therapy, 2008, v. 24 n. 3, p. 165-169 How to Cite?
AbstractObjectives: To examine the effect of rapid aneuploidy testing by amnio-PCR on anxiety levels and quality of life measures in women and their partners with positive Down screening result. Methods: In the original design, screen-positive women were to be randomized to have amnio-PCR or not. Of the first 60 women approached to join the study between April 2004 and April 2005, 4 declined amniocentesis, 14 agreed to be randomized, while the other 42 (75%) chose to pay for the amnio-PCR themselves (3 excluded: 2 because of Down syndrome and 1 dropout). The study was thus performed as a prospective observational study on the remaining 39 women of the last group. The longitudinal profile of the state-anxiety and quality of life domain scores for this cohort were studied using the Spielberger State-Trait Anxiety Inventory and WHO Quality of Life Measure - abbreviated version (Hong Kong) Questionnaire at 5 time points: (1) before amniocentesis, (2) 2 days after amniocentesis when amnio-PCR report was disclosed, (3) 3 weeks after amniocentesis when karyotyping report was disclosed, (4) 30-32 weeks' gestation, (5) 6 weeks after delivery. Results: In the final cohort of 39 women and 27 partners, a significant reduction in their state-anxiety scores was found when they received the normal amnio-PCR report. On the other hand, there was no significant change in their quality of life domain scores. Conclusions: There is a demand from women and their partners who had a positive Down screening result for rapid aneuploidy testing (amnio-PCR) which can effectively alleviate their anxiety. A rapid aneuploidy test should be made available to women in a Down screening programme. Copyright © 2008 S. Karger AG.
Persistent Identifierhttp://hdl.handle.net/10722/180690
ISSN
2015 Impact Factor: 2.7
2015 SCImago Journal Rankings: 1.901
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_US
dc.contributor.authorLau, ETen_US
dc.contributor.authorNgai, Cen_US
dc.contributor.authorLam, Hen_US
dc.contributor.authorLeung, KYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorLao, TTen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:08Z-
dc.date.available2013-01-28T01:41:08Z-
dc.date.issued2008en_US
dc.identifier.citationFetal Diagnosis And Therapy, 2008, v. 24 n. 3, p. 165-169en_US
dc.identifier.issn1015-3837en_US
dc.identifier.urihttp://hdl.handle.net/10722/180690-
dc.description.abstractObjectives: To examine the effect of rapid aneuploidy testing by amnio-PCR on anxiety levels and quality of life measures in women and their partners with positive Down screening result. Methods: In the original design, screen-positive women were to be randomized to have amnio-PCR or not. Of the first 60 women approached to join the study between April 2004 and April 2005, 4 declined amniocentesis, 14 agreed to be randomized, while the other 42 (75%) chose to pay for the amnio-PCR themselves (3 excluded: 2 because of Down syndrome and 1 dropout). The study was thus performed as a prospective observational study on the remaining 39 women of the last group. The longitudinal profile of the state-anxiety and quality of life domain scores for this cohort were studied using the Spielberger State-Trait Anxiety Inventory and WHO Quality of Life Measure - abbreviated version (Hong Kong) Questionnaire at 5 time points: (1) before amniocentesis, (2) 2 days after amniocentesis when amnio-PCR report was disclosed, (3) 3 weeks after amniocentesis when karyotyping report was disclosed, (4) 30-32 weeks' gestation, (5) 6 weeks after delivery. Results: In the final cohort of 39 women and 27 partners, a significant reduction in their state-anxiety scores was found when they received the normal amnio-PCR report. On the other hand, there was no significant change in their quality of life domain scores. Conclusions: There is a demand from women and their partners who had a positive Down screening result for rapid aneuploidy testing (amnio-PCR) which can effectively alleviate their anxiety. A rapid aneuploidy test should be made available to women in a Down screening programme. Copyright © 2008 S. Karger AG.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/FDTen_US
dc.relation.ispartofFetal Diagnosis and Therapyen_US
dc.subject.meshAdulten_US
dc.subject.meshAmniocentesis - Psychologyen_US
dc.subject.meshAnxietyen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDown Syndrome - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Diagnosis - Genetics - Psychologyen_US
dc.subject.meshGenetic Testing - Psychologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMaleen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshQuality Of Lifeen_US
dc.titleA prospective study on the effect of rapid aneuploidy testing (amnio-PCR) on anxiety levels and quality of life measures in women and their partners with positive down screening resulten_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1159/000151332en_US
dc.identifier.pmid18753751-
dc.identifier.scopuseid_2-s2.0-50049103153en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50049103153&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue3en_US
dc.identifier.spage165en_US
dc.identifier.epage169en_US
dc.identifier.isiWOS:000259726100002-
dc.publisher.placeSwitzerlanden_US
dc.identifier.scopusauthoridLeung, WC=7201504435en_US
dc.identifier.scopusauthoridLau, ET=36006491400en_US
dc.identifier.scopusauthoridNgai, C=6603676357en_US
dc.identifier.scopusauthoridLam, H=16022602300en_US
dc.identifier.scopusauthoridLeung, KY=8247106900en_US
dc.identifier.scopusauthoridLee, CP=7410141601en_US
dc.identifier.scopusauthoridLao, TT=35327208900en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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