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Article: A new strategy for prenatal diagnosis of homozygous α 0- thalassemia

TitleA new strategy for prenatal diagnosis of homozygous α 0- thalassemia
Authors
Issue Date2006
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 2006, v. 28 n. 2, p. 173-177 How to Cite?
AbstractObjectives: We have shown previously that ultrasound examination performed by one experienced operator can be useful to exclude homozygous α 0-thalassemia in a tertiary referral center. This study aimed to determine whether the technique was still applicable when performed by several operators and in different centers. Methods: At the Maternal and Neonatal Hospital of Guangzhou (MNH) and Tsan Yuk Hospital of Hong Kong (TYH), women at risk of homozygous α 0-thalassemia were given the option of a non-invasive approach (using serial ultrasound examinations at 12-15, 16-20 and 25-30 weeks' gestation) to exclude an affected pregnancy. The fetal cardiothoracic ratio (CTR) was measured at each of these examinations and the placental thickness was measured at 12-15 weeks' gestation. The operators of MNH received training on the ultrasound examination techniques at TYH and the quality of the subsequent ultrasound examinations was checked regularly. The final diagnosis of homozygous α 0-thalassemia was confirmed using an invasive test. Results: Of 832 at-risk pregnancies studied in the two hospitals, 168 (20.2%) were affected. The overall sensitivity and specificity of the non-invasive approach was 100% and 95.6%, respectively. At MNH, the need for an invasive test was reduced by 80.8%, and all the affected pregnancies were diagnosed before 24 weeks' gestation. The results achieved at MNH were comparable with those at TYH. The at-risk pregnancies including the affected ones presented at a more advanced gestational age at MNH. At each hospital, one affected pregnancy was missed at the 12-week scan but this was subsequently detected at the 15-18-week scan. Conclusions: This non-invasive approach to exclude homozygous α 0-thalassemia can be applicable when it is performed by several operators and in different centers. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180682
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KYen_US
dc.contributor.authorLiao, Cen_US
dc.contributor.authorLi, QMen_US
dc.contributor.authorMa, SYen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorChan, Ven_US
dc.contributor.authorLam, YHen_US
dc.date.accessioned2013-01-28T01:41:04Z-
dc.date.available2013-01-28T01:41:04Z-
dc.date.issued2006en_US
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 2006, v. 28 n. 2, p. 173-177en_US
dc.identifier.issn0960-7692en_US
dc.identifier.urihttp://hdl.handle.net/10722/180682-
dc.description.abstractObjectives: We have shown previously that ultrasound examination performed by one experienced operator can be useful to exclude homozygous α 0-thalassemia in a tertiary referral center. This study aimed to determine whether the technique was still applicable when performed by several operators and in different centers. Methods: At the Maternal and Neonatal Hospital of Guangzhou (MNH) and Tsan Yuk Hospital of Hong Kong (TYH), women at risk of homozygous α 0-thalassemia were given the option of a non-invasive approach (using serial ultrasound examinations at 12-15, 16-20 and 25-30 weeks' gestation) to exclude an affected pregnancy. The fetal cardiothoracic ratio (CTR) was measured at each of these examinations and the placental thickness was measured at 12-15 weeks' gestation. The operators of MNH received training on the ultrasound examination techniques at TYH and the quality of the subsequent ultrasound examinations was checked regularly. The final diagnosis of homozygous α 0-thalassemia was confirmed using an invasive test. Results: Of 832 at-risk pregnancies studied in the two hospitals, 168 (20.2%) were affected. The overall sensitivity and specificity of the non-invasive approach was 100% and 95.6%, respectively. At MNH, the need for an invasive test was reduced by 80.8%, and all the affected pregnancies were diagnosed before 24 weeks' gestation. The results achieved at MNH were comparable with those at TYH. The at-risk pregnancies including the affected ones presented at a more advanced gestational age at MNH. At each hospital, one affected pregnancy was missed at the 12-week scan but this was subsequently detected at the 15-18-week scan. Conclusions: This non-invasive approach to exclude homozygous α 0-thalassemia can be applicable when it is performed by several operators and in different centers. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_US
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_US
dc.subject.meshCardiomegaly - Complications - Ultrasonographyen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobins - Analysisen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshUltrasonography, Prenatal - Methods - Standardsen_US
dc.subject.meshAlpha-Thalassemia - Complications - Ultrasonographyen_US
dc.titleA new strategy for prenatal diagnosis of homozygous α 0- thalassemiaen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/uog.2720en_US
dc.identifier.pmid16652394-
dc.identifier.scopuseid_2-s2.0-33747627169en_US
dc.identifier.hkuros124876-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747627169&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue2en_US
dc.identifier.spage173en_US
dc.identifier.epage177en_US
dc.identifier.isiWOS:000239807100010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, KY=8247106900en_US
dc.identifier.scopusauthoridLiao, C=7401957615en_US
dc.identifier.scopusauthoridLi, QM=24173762300en_US
dc.identifier.scopusauthoridMa, SY=40161690900en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridChan, V=36896382500en_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US

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