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Article: Rapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis?

TitleRapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis?
Authors
Issue Date2004
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/erm
Citation
Expert Review Of Molecular Diagnostics, 2004, v. 4 n. 3, p. 333-337 How to Cite?
AbstractThe accuracy of new molecular diagnostics, fluoresence in situ hybridization or quantitative fluorescence-PCR (collectively known as rapid aneuploidy screening), in prenatal diagnosis has already been demonstrated in a number of large studies. The challenge now is how to apply them clinically in the most cost-effective manner. It is now time to appraise whether rapid aneuploidy screening can replace traditional karyotyping when amniocenteses are performed for increased risk of Down's syndrome by maternal serum screening or advanced maternal age in the absence of ultrasound abnormality. The ten most recent studies from the literature within this research theme are reviewed and the pros and cons of this new approach in prenatal diagnosis are discussed, including the suggestion of future studies.
Persistent Identifierhttp://hdl.handle.net/10722/180676
ISSN
2015 Impact Factor: 3.333
2015 SCImago Journal Rankings: 0.942
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_US
dc.contributor.authorLau, ETen_US
dc.contributor.authorLao, TTen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:02Z-
dc.date.available2013-01-28T01:41:02Z-
dc.date.issued2004en_US
dc.identifier.citationExpert Review Of Molecular Diagnostics, 2004, v. 4 n. 3, p. 333-337en_US
dc.identifier.issn1473-7159en_US
dc.identifier.urihttp://hdl.handle.net/10722/180676-
dc.description.abstractThe accuracy of new molecular diagnostics, fluoresence in situ hybridization or quantitative fluorescence-PCR (collectively known as rapid aneuploidy screening), in prenatal diagnosis has already been demonstrated in a number of large studies. The challenge now is how to apply them clinically in the most cost-effective manner. It is now time to appraise whether rapid aneuploidy screening can replace traditional karyotyping when amniocenteses are performed for increased risk of Down's syndrome by maternal serum screening or advanced maternal age in the absence of ultrasound abnormality. The ten most recent studies from the literature within this research theme are reviewed and the pros and cons of this new approach in prenatal diagnosis are discussed, including the suggestion of future studies.en_US
dc.languageengen_US
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/ermen_US
dc.relation.ispartofExpert Review of Molecular Diagnosticsen_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshAneuploidyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFalse Negative Reactionsen_US
dc.subject.meshFalse Positive Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Economics - Utilizationen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMolecular Diagnostic Techniquesen_US
dc.subject.meshPolymerase Chain Reaction - Economics - Utilizationen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosis - Methodsen_US
dc.titleRapid aneuploidy screening (FISH or QF-PCR): The changing scene in prenatal diagnosis?en_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1586/14737159.4.3.333en_US
dc.identifier.pmid15137900-
dc.identifier.scopuseid_2-s2.0-2542421711en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542421711&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue3en_US
dc.identifier.spage333en_US
dc.identifier.epage337en_US
dc.identifier.isiWOS:000221285900007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, WC=7201504435en_US
dc.identifier.scopusauthoridLau, ET=7103086081en_US
dc.identifier.scopusauthoridLao, TT=7005722132en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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