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Article: Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood

TitleSimple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood
Authors
Issue Date2005
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2005, v. 25 n. 2, p. 123-128 How to Cite?
AbstractObjective: To investigate a simple non-invasive technique for early detection of Hemoglobin (Hb) Bart's disease. Method: Maternal blood smears from 8 known Hb Bart's pregnancies and 40 at-risk pregnancies were investigated. Maternal peripheral blood smears were stained with fluorescence-labeled monoclonal antibodies against α- and embryonic ζ-globin chains. Results: Fetal nonnucleated red blood cells, stained with anti-ζ but not with anti-α globin antibodies were found in 15 out of 16 affected pregnancies but were not detected in 23 out of 24 unaffected pregnancies. Conclusion: Results showed that non-invasive immunofluorescence staining of maternal blood is a feasible approach for screening Hb Bart's disease before ultrasound manifestation in affected pregnancies. Copyright © 2005 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180671
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, ETen_US
dc.contributor.authorKwok, YKen_US
dc.contributor.authorLuo, HYen_US
dc.contributor.authorLeung, KYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorLam, YHen_US
dc.contributor.authorChui, DHKen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:41:00Z-
dc.date.available2013-01-28T01:41:00Z-
dc.date.issued2005en_US
dc.identifier.citationPrenatal Diagnosis, 2005, v. 25 n. 2, p. 123-128en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180671-
dc.description.abstractObjective: To investigate a simple non-invasive technique for early detection of Hemoglobin (Hb) Bart's disease. Method: Maternal blood smears from 8 known Hb Bart's pregnancies and 40 at-risk pregnancies were investigated. Maternal peripheral blood smears were stained with fluorescence-labeled monoclonal antibodies against α- and embryonic ζ-globin chains. Results: Fetal nonnucleated red blood cells, stained with anti-ζ but not with anti-α globin antibodies were found in 15 out of 16 affected pregnancies but were not detected in 23 out of 24 unaffected pregnancies. Conclusion: Results showed that non-invasive immunofluorescence staining of maternal blood is a feasible approach for screening Hb Bart's disease before ultrasound manifestation in affected pregnancies. Copyright © 2005 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshErythrocytes - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blood - Chemistryen_US
dc.subject.meshGlobins - Analysis - Immunologyen_US
dc.subject.meshHemoglobins, Abnormal - Analysis - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrops Fetalis - Blood - Diagnosis - Epidemiology - Etiologyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshProspective Studiesen_US
dc.titleSimple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blooden_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1096en_US
dc.identifier.pmid15712347-
dc.identifier.scopuseid_2-s2.0-14744267781en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14744267781&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.spage123en_US
dc.identifier.epage128en_US
dc.identifier.isiWOS:000227342300004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, ET=36006491400en_US
dc.identifier.scopusauthoridKwok, YK=8247106700en_US
dc.identifier.scopusauthoridLuo, HY=37116363100en_US
dc.identifier.scopusauthoridLeung, KY=8247106900en_US
dc.identifier.scopusauthoridLee, CP=7410141601en_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridChui, DHK=34568906600en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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