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Article: Middle cerebral artery Doppler study in fetuses with homozygous α-thalassaemia-1 at 12-13 weeks of gestation

TitleMiddle cerebral artery Doppler study in fetuses with homozygous α-thalassaemia-1 at 12-13 weeks of gestation
Authors
Issue Date2002
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2002, v. 22 n. 1, p. 56-58 How to Cite?
AbstractObjective: Fetuses affected by homozygous α-thalassaemia-1 are anaemic from the first trimester of pregnancy. We investigated middle cerebral artery Doppler velocimetry in these affected fetuses at 12-13 weeks of gestation to assess its use in predicting fetal anaemia. Methods: Women referred for the prenatal diagnosis of homozygous α-thalassaemia-1 before 14 weeks of gestation were recruited. All fetuses underwent pulsed Doppler examinations following colour flow mapping at 12 or 13 weeks of gestation. Homozygous α-thalassaemia-1 was diagnosed by DNA or haemoglobin study. The middle cerebral artery Doppler indices were compared between the affected fetuses and fetuses unaffected by homozygous α-thalassaemia-1. Results: Between 1998 and 2000, 80 eligible women were recruited. Of these, 19 fetuses were affected by homozygous α-thalassaemia-1. Two of them showed hydropic changes at the time of Doppler study. The affected fetuses had significantly higher middle cerebral artery peak systolic velocity (Vmax) (36% increase) and time-averaged maximum velocity (Vtamx) (33% increase). Conclusion: The increase of cerebral blood flow in affected fetuses is consistent with our previous finding of an increased forward flow in the ductus venosus, cardiac dilatation and an increase of cardiac output to preferentially shunt more oxygenated blood to the brain as a compensatory mechanism. However, extensive overlap of the middle cerebral artery flow velocity values between affected and unaffected fetuses precludes its use in predicting anaemia at 12-13 weeks' gestation. Copyright © 2002 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180664
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:57Z-
dc.date.available2013-01-28T01:40:57Z-
dc.date.issued2002en_US
dc.identifier.citationPrenatal Diagnosis, 2002, v. 22 n. 1, p. 56-58en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180664-
dc.description.abstractObjective: Fetuses affected by homozygous α-thalassaemia-1 are anaemic from the first trimester of pregnancy. We investigated middle cerebral artery Doppler velocimetry in these affected fetuses at 12-13 weeks of gestation to assess its use in predicting fetal anaemia. Methods: Women referred for the prenatal diagnosis of homozygous α-thalassaemia-1 before 14 weeks of gestation were recruited. All fetuses underwent pulsed Doppler examinations following colour flow mapping at 12 or 13 weeks of gestation. Homozygous α-thalassaemia-1 was diagnosed by DNA or haemoglobin study. The middle cerebral artery Doppler indices were compared between the affected fetuses and fetuses unaffected by homozygous α-thalassaemia-1. Results: Between 1998 and 2000, 80 eligible women were recruited. Of these, 19 fetuses were affected by homozygous α-thalassaemia-1. Two of them showed hydropic changes at the time of Doppler study. The affected fetuses had significantly higher middle cerebral artery peak systolic velocity (Vmax) (36% increase) and time-averaged maximum velocity (Vtamx) (33% increase). Conclusion: The increase of cerebral blood flow in affected fetuses is consistent with our previous finding of an increased forward flow in the ductus venosus, cardiac dilatation and an increase of cardiac output to preferentially shunt more oxygenated blood to the brain as a compensatory mechanism. However, extensive overlap of the middle cerebral artery flow velocity values between affected and unaffected fetuses precludes its use in predicting anaemia at 12-13 weeks' gestation. Copyright © 2002 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Physiopathologyen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHemoglobins - Analysisen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshLaser-Doppler Flowmetryen_US
dc.subject.meshMiddle Cerebral Artery - Physiopathologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshSystoleen_US
dc.subject.meshAlpha-Thalassemia - Diagnosis - Genetics - Physiopathologyen_US
dc.titleMiddle cerebral artery Doppler study in fetuses with homozygous α-thalassaemia-1 at 12-13 weeks of gestationen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.237en_US
dc.identifier.pmid11810652-
dc.identifier.scopuseid_2-s2.0-0036173092en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036173092&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.spage56en_US
dc.identifier.epage58en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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