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Article: The effect of fast reporting by amnio-PCR on anxiety levels in women with positive biochemical screening for Down syndrome - A randomized controlled trial

TitleThe effect of fast reporting by amnio-PCR on anxiety levels in women with positive biochemical screening for Down syndrome - A randomized controlled trial
Authors
Issue Date2002
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2002, v. 22 n. 3, p. 256-259 How to Cite?
AbstractObjective: To study the effect of fast reporting by polymerase chain reaction on amniotic fluid cells (amnio-PCR) on anxiety levels in women with positive biochemical screening for Down syndrome. Method: Between May 2000 and April 2001, 60 screen-positive women were randomized before amniocentesis into either having (group A) or not having (group B) fast-reporting by amnio-PCR. Anxiety levels were measured by the Spielberger State-Trait Anxiety Inventory just prior to amniocentesis, three days (when PCR results were known to group A) and three weeks (when standard karyotype results were known to both groups) afterwards. Results: Two women were excluded because in one woman amnio-PCR showed trisomy 21 and the other miscarried shortly after amniocentesis. The state-anxiety scores increased over the three-week period after being informed of the positive-screen result in both groups. The trait- and state-anxiety scores at all points did not differ between the two groups. Conclusions: In contrast to the general belief, fast reporting by amnio-PCR did not alleviate anxiety in women who are screen-positive for Down syndrome. Copyright © 2002 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180663
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_US
dc.contributor.authorLam, YHen_US
dc.contributor.authorWong, Yen_US
dc.contributor.authorLau, ETen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:57Z-
dc.date.available2013-01-28T01:40:57Z-
dc.date.issued2002en_US
dc.identifier.citationPrenatal Diagnosis, 2002, v. 22 n. 3, p. 256-259en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180663-
dc.description.abstractObjective: To study the effect of fast reporting by polymerase chain reaction on amniotic fluid cells (amnio-PCR) on anxiety levels in women with positive biochemical screening for Down syndrome. Method: Between May 2000 and April 2001, 60 screen-positive women were randomized before amniocentesis into either having (group A) or not having (group B) fast-reporting by amnio-PCR. Anxiety levels were measured by the Spielberger State-Trait Anxiety Inventory just prior to amniocentesis, three days (when PCR results were known to group A) and three weeks (when standard karyotype results were known to both groups) afterwards. Results: Two women were excluded because in one woman amnio-PCR showed trisomy 21 and the other miscarried shortly after amniocentesis. The state-anxiety scores increased over the three-week period after being informed of the positive-screen result in both groups. The trait- and state-anxiety scores at all points did not differ between the two groups. Conclusions: In contrast to the general belief, fast reporting by amnio-PCR did not alleviate anxiety in women who are screen-positive for Down syndrome. Copyright © 2002 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdulten_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshAmniotic Fluid - Cytologyen_US
dc.subject.meshAnxietyen_US
dc.subject.meshDown Syndrome - Diagnosis - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMaternal Ageen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy, High-Risken_US
dc.subject.meshPrenatal Diagnosis - Psychologyen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshTime Factorsen_US
dc.titleThe effect of fast reporting by amnio-PCR on anxiety levels in women with positive biochemical screening for Down syndrome - A randomized controlled trialen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.314en_US
dc.identifier.pmid11920905-
dc.identifier.scopuseid_2-s2.0-0036126106en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036126106&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue3en_US
dc.identifier.spage256en_US
dc.identifier.epage259en_US
dc.identifier.isiWOS:000174542900018-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, WC=7201504435en_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridWong, Y=24073787400en_US
dc.identifier.scopusauthoridLau, ET=7103086081en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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