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Article: Embryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures

TitleEmbryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell cultures
Authors
Issue Date2001
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2001, v. 21 n. 7, p. 529-539 How to Cite?
AbstractThe understanding of human hemoglobin ontogeny during development is of biological and clinical importance. Molecular and immunocytological techniques were used to study the expression of embryonic zeta (ζ), epsilon (ε), and fetal gamma (γ) globin genes in newborn cord blood, peripheral blood from men, pregnant and non-pregnant women, and in vitro mononuclear cell cultures. We have shown that embryonic and fetal globin mRNA and peptides are expressed in cultured erythroid cells and in circulating blood cells from newborns, adult non-pregnant women and from men. The findings suggest that during erythroid cell differentiation in newborns and adults, there is a transient recapitulation of sequential globin chain expression as found during embryonic and fetal development. Furthermore, these findings underscore the need for caution in using embryonic and fetal globin chains as markers to identify erythroid cells of fetal origin in maternal circulation for prenatal diagnosis. Copyright © 2001 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180659
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, ETen_US
dc.contributor.authorKwok, YKen_US
dc.contributor.authorChui, DHKen_US
dc.contributor.authorWong, HSen_US
dc.contributor.authorLuo, HYen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:56Z-
dc.date.available2013-01-28T01:40:56Z-
dc.date.issued2001en_US
dc.identifier.citationPrenatal Diagnosis, 2001, v. 21 n. 7, p. 529-539en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180659-
dc.description.abstractThe understanding of human hemoglobin ontogeny during development is of biological and clinical importance. Molecular and immunocytological techniques were used to study the expression of embryonic zeta (ζ), epsilon (ε), and fetal gamma (γ) globin genes in newborn cord blood, peripheral blood from men, pregnant and non-pregnant women, and in vitro mononuclear cell cultures. We have shown that embryonic and fetal globin mRNA and peptides are expressed in cultured erythroid cells and in circulating blood cells from newborns, adult non-pregnant women and from men. The findings suggest that during erythroid cell differentiation in newborns and adults, there is a transient recapitulation of sequential globin chain expression as found during embryonic and fetal development. Furthermore, these findings underscore the need for caution in using embryonic and fetal globin chains as markers to identify erythroid cells of fetal origin in maternal circulation for prenatal diagnosis. Copyright © 2001 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdulten_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDna Primersen_US
dc.subject.meshErythroid Precursor Cellsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blooden_US
dc.subject.meshFetal Hemoglobin - Genetics - Immunologyen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshGlobins - Genetics - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRna, Messenger - Isolation & Purificationen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titleEmbryonic and fetal globins are expressed in adult erythroid progenitor cells and in erythroid cell culturesen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.81en_US
dc.identifier.pmid11494285-
dc.identifier.scopuseid_2-s2.0-0034879213en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034879213&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue7en_US
dc.identifier.spage529en_US
dc.identifier.epage539en_US
dc.identifier.isiWOS:000170478700002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLau, ET=36006491400en_US
dc.identifier.scopusauthoridKwok, YK=8247106700en_US
dc.identifier.scopusauthoridChui, DHK=7005111153en_US
dc.identifier.scopusauthoridWong, HS=7402864769en_US
dc.identifier.scopusauthoridLuo, HY=37116363100en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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