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- Publisher Website: 10.1002/pd.120
- Scopus: eid_2-s2.0-0034855772
- PMID: 11536266
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Article: The effect of fetal gender on second-trimester maternal serum inhibin-a concentration
Title | The effect of fetal gender on second-trimester maternal serum inhibin-a concentration |
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Authors | |
Keywords | Down syndrome Gender Inhibin-A Sex |
Issue Date | 2001 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 |
Citation | Prenatal Diagnosis, 2001, v. 21 n. 8, p. 662-664 How to Cite? |
Abstract | Second-trimester serum inhibin-A is increasingly used as a fourth marker in addition to the triple test to screen for Down syndrome. We investigated whether fetal gender had an effect on serum inhibin-A concentration. A retrospective analysis was done on 316 normal pregnancies and 48 Down syndrome pregnancies in which maternal serum inhibin-A assays were performed between 15 and 20 weeks of gestation and in which the fetal sex was known. The median inhibin-A MoM (95% CI) for normal pregnancies in the presence of a male fetus was 0.93 (range 0.88-1.03). This was significantly lower than that in the presence of a female fetus (median MoM = 1.04). The gender difference was not observed in the Down syndrome pregnancies. The increased inhibin-A concentration would lead to a 2.3-fold higher false-positive rate in the presence of a female fetus (10.6% vs 4.6%; p < 0.05, Chi-square test). Because of the small number of cases studied, the results need to be substantiated by a larger series. If the gender effect is confirmed, adjustment for fetal sex may be necessary when inhibin-A is used as a screening marker. Copyright © 2001 John Wiley & Sons, Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/180658 |
ISSN | 2021 Impact Factor: 3.242 2020 SCImago Journal Rankings: 0.956 |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lam, YH | en_US |
dc.contributor.author | Tang, MHY | en_US |
dc.date.accessioned | 2013-01-28T01:40:55Z | - |
dc.date.available | 2013-01-28T01:40:55Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Prenatal Diagnosis, 2001, v. 21 n. 8, p. 662-664 | en_US |
dc.identifier.issn | 0197-3851 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/180658 | - |
dc.description.abstract | Second-trimester serum inhibin-A is increasingly used as a fourth marker in addition to the triple test to screen for Down syndrome. We investigated whether fetal gender had an effect on serum inhibin-A concentration. A retrospective analysis was done on 316 normal pregnancies and 48 Down syndrome pregnancies in which maternal serum inhibin-A assays were performed between 15 and 20 weeks of gestation and in which the fetal sex was known. The median inhibin-A MoM (95% CI) for normal pregnancies in the presence of a male fetus was 0.93 (range 0.88-1.03). This was significantly lower than that in the presence of a female fetus (median MoM = 1.04). The gender difference was not observed in the Down syndrome pregnancies. The increased inhibin-A concentration would lead to a 2.3-fold higher false-positive rate in the presence of a female fetus (10.6% vs 4.6%; p < 0.05, Chi-square test). Because of the small number of cases studied, the results need to be substantiated by a larger series. If the gender effect is confirmed, adjustment for fetal sex may be necessary when inhibin-A is used as a screening marker. Copyright © 2001 John Wiley & Sons, Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252 | en_US |
dc.relation.ispartof | Prenatal Diagnosis | en_US |
dc.subject | Down syndrome | - |
dc.subject | Gender | - |
dc.subject | Inhibin-A | - |
dc.subject | Sex | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Biological Markers - Blood | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Down Syndrome - Blood | en_US |
dc.subject.mesh | False Positive Reactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gestational Age | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inhibins - Blood | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy Trimester, Second | en_US |
dc.subject.mesh | Reference Values | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Sex | en_US |
dc.title | The effect of fetal gender on second-trimester maternal serum inhibin-a concentration | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tang, MHY: mhytang@hkucc.hku.hk | en_US |
dc.identifier.authority | Tang, MHY=rp01701 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/pd.120 | en_US |
dc.identifier.pmid | 11536266 | - |
dc.identifier.scopus | eid_2-s2.0-0034855772 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0034855772&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 662 | en_US |
dc.identifier.epage | 664 | en_US |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lam, YH=7202563903 | en_US |
dc.identifier.scopusauthorid | Tang, MHY=8943401300 | en_US |
dc.identifier.issnl | 0197-3851 | - |