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Article: Acceptability of serum screening as an alternative to cytogenetic diagnosis of Down syndrome among women 35 years or older in Hong Kong

TitleAcceptability of serum screening as an alternative to cytogenetic diagnosis of Down syndrome among women 35 years or older in Hong Kong
Authors
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 6, p. 487-490 How to Cite?
AbstractThe addition of second trimester serum markers to maternal age increases the efficacy of screening for Down syndrome by maternal age alone. Among women aged 35 years or older, serum screening makes a large proportion of amniocentesis unnecessary. However, there are ethical and medicolegal concerns about serum screening in 'old' women, largely because some of the pregnancies affected by Down syndrome and other chromosomal abnormalities may not be detected. We investigated the acceptability of serum screening in women aged 35 years or older when it was offered as an alternative to prenatal cytogenetic diagnosis after detailed counselling. Women referred for prenatal diagnosis of Down syndrome because of advanced maternal age were given the options of cytogenetic diagnosis by chorionic villus sampling (CVS) or amniocentesis. As an alternative, they could choose to undergo second trimester serum human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) screening first before deciding on whether to undergo amniocentesis. Between January 1997 and October 1999, 3419 subjects were recruited. 1807 women (52.9%) chose to undergo serum screening, 1516 women (44.3%) chose to have amniocentesis and 96 women chose to have CVS (2.8%). The proportion of women who chose serum screening rose steadily from 38.8% in the year of 1997 to 63.4% in 1999. Significantly fewer Chinese women chose serum screening than non-Chinese. The decision as to whether to undergo an invasive diagnostic procedure or to be content with the relatively safer but less accurate screening test varies, being affected by the women's background and culture. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/180652
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorSin, SYen_US
dc.contributor.authorTang, Ren_US
dc.contributor.authorWong, HSen_US
dc.contributor.authorWong, SFen_US
dc.date.accessioned2013-01-28T01:40:54Z-
dc.date.available2013-01-28T01:40:54Z-
dc.date.issued2000en_US
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 6, p. 487-490en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180652-
dc.description.abstractThe addition of second trimester serum markers to maternal age increases the efficacy of screening for Down syndrome by maternal age alone. Among women aged 35 years or older, serum screening makes a large proportion of amniocentesis unnecessary. However, there are ethical and medicolegal concerns about serum screening in 'old' women, largely because some of the pregnancies affected by Down syndrome and other chromosomal abnormalities may not be detected. We investigated the acceptability of serum screening in women aged 35 years or older when it was offered as an alternative to prenatal cytogenetic diagnosis after detailed counselling. Women referred for prenatal diagnosis of Down syndrome because of advanced maternal age were given the options of cytogenetic diagnosis by chorionic villus sampling (CVS) or amniocentesis. As an alternative, they could choose to undergo second trimester serum human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) screening first before deciding on whether to undergo amniocentesis. Between January 1997 and October 1999, 3419 subjects were recruited. 1807 women (52.9%) chose to undergo serum screening, 1516 women (44.3%) chose to have amniocentesis and 96 women chose to have CVS (2.8%). The proportion of women who chose serum screening rose steadily from 38.8% in the year of 1997 to 63.4% in 1999. Significantly fewer Chinese women chose serum screening than non-Chinese. The decision as to whether to undergo an invasive diagnostic procedure or to be content with the relatively safer but less accurate screening test varies, being affected by the women's background and culture. Copyright (C) 2000 John Wiley and Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdulten_US
dc.subject.meshAmniocentesisen_US
dc.subject.meshChorionic Gonadotropin - Blooden_US
dc.subject.meshChorionic Villi Samplingen_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshDown Syndrome - Diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaternal Ageen_US
dc.subject.meshPatient Acceptance Of Health Careen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy, High-Risken_US
dc.subject.meshPrenatal Diagnosis - Methodsen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleAcceptability of serum screening as an alternative to cytogenetic diagnosis of Down syndrome among women 35 years or older in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0223(200006)20:6<487::AID-PD853>3.0.CO;2-2en_US
dc.identifier.pmid10861714-
dc.identifier.scopuseid_2-s2.0-0034041081en_US
dc.identifier.hkuros51406-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034041081&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue6en_US
dc.identifier.spage487en_US
dc.identifier.epage490en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridSin, SY=7006553270en_US
dc.identifier.scopusauthoridTang, R=7202300287en_US
dc.identifier.scopusauthoridWong, HS=7402864769en_US
dc.identifier.scopusauthoridWong, SF=7404591050en_US

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