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Article: Cardiac blood flow studies in fetuses with homozygous α-thalassemia-1 at 12-13 weeks of gestation

TitleCardiac blood flow studies in fetuses with homozygous α-thalassemia-1 at 12-13 weeks of gestation
Authors
Issue Date1999
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 1999, v. 13 n. 1, p. 48-51 How to Cite?
AbstractObjective. Fetuses affected by homozygous α-thalassemia-1 develop anemia as early as the first trimester. Our objective was to study hemodynamic indices in affected fetuses at 12-13 weeks of gestation to determine whether these would be useful in the prediction of anemia. Design. Prospective observational study. Subjects. Women referred before 14 weeks of gestation for the prenatal diagnosis of homozygous α-thalassemia-1. Methods. Transabdominal and/or transvaginal Doppler sonography was performed to measure the flow velocities in the fetal ascending aorta and pulmonary artery at 12-13 weeks. The Doppler indices were compared between those that were subsequently confirmed to be affected by homozygous α-thalassemia-1 and those that were unaffected. Results. Between June 1997 and April 1998, 60 eligible women were recruited. Doppler examination was successful in 58 fetuses. Of these, 22 were subsequently confirmed to be affected by homozygous α-thalassemia-1. The diagnosis was made by chorionic villus sampling and DNA analysis in two affected fetuses and by cordocentesis and hemoglobin evaluation in 20 affected fetuses. Hemoglobin concentrations could be measured in ten fetuses and these ranged from 4 to 8 g/dl. The affected fetuses had significantly higher peak velocities at the pulmonary valve and ascending aorta and a larger inner diameter of the pulmonary valve than that in unaffected fetuses. The total cardiac output was increased by one-third in affected fetuses and was mainly due to an increase of the right-side cardiac output. Conclusion. In the early stage of anemia, the fetus responds mainly by increasing its right-side cardiac output. However, there is extensive overlap of the values of cardiac output between the affected and the unaffected fetuses, precluding its use in the prediction of anemia.
Persistent Identifierhttp://hdl.handle.net/10722/180648
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorTse, HYen_US
dc.date.accessioned2013-01-28T01:40:52Z-
dc.date.available2013-01-28T01:40:52Z-
dc.date.issued1999en_US
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 1999, v. 13 n. 1, p. 48-51en_US
dc.identifier.issn0960-7692en_US
dc.identifier.urihttp://hdl.handle.net/10722/180648-
dc.description.abstractObjective. Fetuses affected by homozygous α-thalassemia-1 develop anemia as early as the first trimester. Our objective was to study hemodynamic indices in affected fetuses at 12-13 weeks of gestation to determine whether these would be useful in the prediction of anemia. Design. Prospective observational study. Subjects. Women referred before 14 weeks of gestation for the prenatal diagnosis of homozygous α-thalassemia-1. Methods. Transabdominal and/or transvaginal Doppler sonography was performed to measure the flow velocities in the fetal ascending aorta and pulmonary artery at 12-13 weeks. The Doppler indices were compared between those that were subsequently confirmed to be affected by homozygous α-thalassemia-1 and those that were unaffected. Results. Between June 1997 and April 1998, 60 eligible women were recruited. Doppler examination was successful in 58 fetuses. Of these, 22 were subsequently confirmed to be affected by homozygous α-thalassemia-1. The diagnosis was made by chorionic villus sampling and DNA analysis in two affected fetuses and by cordocentesis and hemoglobin evaluation in 20 affected fetuses. Hemoglobin concentrations could be measured in ten fetuses and these ranged from 4 to 8 g/dl. The affected fetuses had significantly higher peak velocities at the pulmonary valve and ascending aorta and a larger inner diameter of the pulmonary valve than that in unaffected fetuses. The total cardiac output was increased by one-third in affected fetuses and was mainly due to an increase of the right-side cardiac output. Conclusion. In the early stage of anemia, the fetus responds mainly by increasing its right-side cardiac output. However, there is extensive overlap of the values of cardiac output between the affected and the unaffected fetuses, precluding its use in the prediction of anemia.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_US
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAorta - Physiopathology - Ultrasonographyen_US
dc.subject.meshBlood Flow Velocityen_US
dc.subject.meshChorionic Villi Samplingen_US
dc.subject.meshCoronary Circulationen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Heart - Physiopathologyen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHemoglobins - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshPulmonary Artery - Physiopathology - Ultrasonographyen_US
dc.subject.meshUltrasonography, Doppleren_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.subject.meshAlpha-Thalassemia - Genetics - Physiopathologyen_US
dc.titleCardiac blood flow studies in fetuses with homozygous α-thalassemia-1 at 12-13 weeks of gestationen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1469-0705.1999.13010048.xen_US
dc.identifier.pmid10201086-
dc.identifier.scopuseid_2-s2.0-0033013781en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033013781&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.spage48en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:000079009300008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridTse, HY=36772585300en_US

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