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Article: Second-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women

TitleSecond-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian women
Authors
Issue Date1999
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1999, v. 19 n. 5, p. 463-467 How to Cite?
AbstractCase-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin-A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin-A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin-A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29-1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. However, inhibin-A MOMs were strongly correlated with hCG MOMs in the cases (r = 0.73, p < 0.001) and the controls (r = 0.56, p < 0.001). This will diminish the value of adding inhibin-A to the existing hCG and AFP screening protocol.
Persistent Identifierhttp://hdl.handle.net/10722/180644
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.date.accessioned2013-01-28T01:40:51Z-
dc.date.available2013-01-28T01:40:51Z-
dc.date.issued1999en_US
dc.identifier.citationPrenatal Diagnosis, 1999, v. 19 n. 5, p. 463-467en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180644-
dc.description.abstractCase-control studies in the Caucasian population showed that maternal serum inhibin-A is elevated in Down syndrome pregnancies and may be a useful second-trimester marker in addition to human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP). Data in the Asian population are lacking. We measured inhibin-A levels in the stored maternal sera of 49 Down syndrome pregnancies and 341 controls with a commercially available assay and expressed them as the multiples of the median of the gestational week. The log means and standard deviations for case and control inhibin-A MOMs were 0.209, 0.226, and 0.002 and 0.177, respectively. Median inhibin-A MOM in Down syndrome cases was elevated to 1.62 (95 per cent confidence interval, 1.29-1.82). 36 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. However, inhibin-A MOMs were strongly correlated with hCG MOMs in the cases (r = 0.73, p < 0.001) and the controls (r = 0.56, p < 0.001). This will diminish the value of adding inhibin-A to the existing hCG and AFP screening protocol.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChorionic Gonadotropin - Blooden_US
dc.subject.meshDown Syndrome - Blood - Diagnosis - Embryologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Blood - Diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshInhibins - Blooden_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleSecond-trimester maternal serum inhibin-A screening for fetal Down syndrome in Asian womenen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(199905)19:5<463::AID-PD574>3.0.CO;2-Qen_US
dc.identifier.pmid10360516-
dc.identifier.scopuseid_2-s2.0-0032927899en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032927899&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.spage463en_US
dc.identifier.epage467en_US
dc.identifier.isiWOS:000080433900011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US

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