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Article: Echogenic bowel in fetuses with homozygous α-thalassemia-1 in the first and second trimesters

TitleEchogenic bowel in fetuses with homozygous α-thalassemia-1 in the first and second trimesters
Authors
Issue Date1999
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/
Citation
Ultrasound In Obstetrics And Gynecology, 1999, v. 14 n. 3, p. 180-182 How to Cite?
AbstractObjective: Fetal echogenic bowel has been observed in fetuses with meconium peritonitis, cystic fibrosis, aneuploidy, congenital viral infection and intrauterine growth restriction. The pathogenesis of echogenic bowel is unknown, but it may be attributed to bowel ischemia. Fetuses affected by homozygous α-thalassemia-1 are severely anemic and hypoxic. We investigated the incidence of echogenic bowel in these hypoxic fetuses in the first and second trimesters. Design: Prospective observational study. Subjects: Women referred for the prenatal diagnosis of homozygous α-thalassemia-1 before 24 weeks' gestation. Methods: All subjects had one or more abdominal and/or vaginal ultrasound examination between 12 and 24 weeks' gestation. Echogenic bowel was diagnosed if the bowel appeared either isoechogenic or more echogenic than the bone. Results: Between March 1997 and July 1998, 126 pregnancies were studied. Thirty-six fetuses were confirmed to be affected by homozygous α-thalassemia-1, and 11 of them (31%, 95% CI 16-48%) had echogenic bowel. These observations were made before the invasive test results were available. None of the fetuses unaffected by homozygous α-thalassemia-1 had echogenic bowel. Conclusion: There is a strong association between homozygous α-thalassemia-1 and echogenic bowel. The pathogenesis is unknown. Speculations include bowel hypoperistalsis or bowel wall edema due to severe anemia and hypoxia.
Persistent Identifierhttp://hdl.handle.net/10722/180638
ISSN
2015 Impact Factor: 4.197
2015 SCImago Journal Rankings: 1.766
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorLee, CPen_US
dc.contributor.authorTse, HYen_US
dc.date.accessioned2013-01-28T01:40:49Z-
dc.date.available2013-01-28T01:40:49Z-
dc.date.issued1999en_US
dc.identifier.citationUltrasound In Obstetrics And Gynecology, 1999, v. 14 n. 3, p. 180-182en_US
dc.identifier.issn0960-7692en_US
dc.identifier.urihttp://hdl.handle.net/10722/180638-
dc.description.abstractObjective: Fetal echogenic bowel has been observed in fetuses with meconium peritonitis, cystic fibrosis, aneuploidy, congenital viral infection and intrauterine growth restriction. The pathogenesis of echogenic bowel is unknown, but it may be attributed to bowel ischemia. Fetuses affected by homozygous α-thalassemia-1 are severely anemic and hypoxic. We investigated the incidence of echogenic bowel in these hypoxic fetuses in the first and second trimesters. Design: Prospective observational study. Subjects: Women referred for the prenatal diagnosis of homozygous α-thalassemia-1 before 24 weeks' gestation. Methods: All subjects had one or more abdominal and/or vaginal ultrasound examination between 12 and 24 weeks' gestation. Echogenic bowel was diagnosed if the bowel appeared either isoechogenic or more echogenic than the bone. Results: Between March 1997 and July 1998, 126 pregnancies were studied. Thirty-six fetuses were confirmed to be affected by homozygous α-thalassemia-1, and 11 of them (31%, 95% CI 16-48%) had echogenic bowel. These observations were made before the invasive test results were available. None of the fetuses unaffected by homozygous α-thalassemia-1 had echogenic bowel. Conclusion: There is a strong association between homozygous α-thalassemia-1 and echogenic bowel. The pathogenesis is unknown. Speculations include bowel hypoperistalsis or bowel wall edema due to severe anemia and hypoxia.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0960-7692/en_US
dc.relation.ispartofUltrasound in Obstetrics and Gynecologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Ultrasonographyen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestines - Embryology - Ultrasonographyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Firsten_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshUltrasonography, Prenatalen_US
dc.subject.meshAlpha-Thalassemia - Ultrasonographyen_US
dc.titleEchogenic bowel in fetuses with homozygous α-thalassemia-1 in the first and second trimestersen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1469-0705.1999.14030180.xen_US
dc.identifier.pmid10550877-
dc.identifier.scopuseid_2-s2.0-0032710327en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032710327&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.spage180en_US
dc.identifier.epage182en_US
dc.identifier.isiWOS:000083396700007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, YH=7202563903en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridLee, CP=7410149538en_US
dc.identifier.scopusauthoridTse, HY=36772585300en_US

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