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Article: Second-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for Down's syndrome in Hong Kong

TitleSecond-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for Down's syndrome in Hong Kong
Authors
KeywordsChinese
Down's syndrome
Screening
Second trimester
Issue Date1998
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1998, v. 18 n. 6, p. 585-589 How to Cite?
AbstractSecond-trimester maternal serum screening for fetal Down's syndrome is well established in many Western countries. Its usefulness and acceptability is unknown in the Asian countries. Between June 1994 and December 1996, we offered second-trimester serum AFP and hCG screening to pregnant women in Hong Kong who were less than 35 years old and without other risk factors for chromosomal abnormalities. Each woman was assigned a risk of having a Down's syndrome term pregnancy by using a computer software program that took into account her age, weight, AFP and hCG MOMs. All those with a risk of one in 250 or greater were designated screen-positive, subject to the revision of gestation by ultrasound examination. 9177 women with singleton pregnancies (93 per cent were Chinese) were screened. The uptake of screening was 75 per cent. 281 women (three per cent) were initially classified to be screen-positive. After revision of the gestation by ultrasound examination, 183 women (two per cent) were 'true' screen-positive and 164 (90 per cent) accepted the offer of amniocentesis. Eight of these pregnancies were affected by Down's syndrome and all the women elected pregnancy termination. The odds of being affected, given a positive screening result, were one in 23. Six Down's syndrome pregnancies were missed by the screening programme. The detection rate was 57 per cent. The study showed that second-trimester serum screening for fetal Down's syndrome was feasible and acceptable in the Hong Kong population.
Persistent Identifierhttp://hdl.handle.net/10722/180634
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_HK
dc.contributor.authorGhosh, Aen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorTang, LCHen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorSin, SYen_HK
dc.contributor.authorHo, PKHen_HK
dc.date.accessioned2013-01-28T01:40:47Z-
dc.date.available2013-01-28T01:40:47Z-
dc.date.issued1998en_HK
dc.identifier.citationPrenatal Diagnosis, 1998, v. 18 n. 6, p. 585-589en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/180634-
dc.description.abstractSecond-trimester maternal serum screening for fetal Down's syndrome is well established in many Western countries. Its usefulness and acceptability is unknown in the Asian countries. Between June 1994 and December 1996, we offered second-trimester serum AFP and hCG screening to pregnant women in Hong Kong who were less than 35 years old and without other risk factors for chromosomal abnormalities. Each woman was assigned a risk of having a Down's syndrome term pregnancy by using a computer software program that took into account her age, weight, AFP and hCG MOMs. All those with a risk of one in 250 or greater were designated screen-positive, subject to the revision of gestation by ultrasound examination. 9177 women with singleton pregnancies (93 per cent were Chinese) were screened. The uptake of screening was 75 per cent. 281 women (three per cent) were initially classified to be screen-positive. After revision of the gestation by ultrasound examination, 183 women (two per cent) were 'true' screen-positive and 164 (90 per cent) accepted the offer of amniocentesis. Eight of these pregnancies were affected by Down's syndrome and all the women elected pregnancy termination. The odds of being affected, given a positive screening result, were one in 23. Six Down's syndrome pregnancies were missed by the screening programme. The detection rate was 57 per cent. The study showed that second-trimester serum screening for fetal Down's syndrome was feasible and acceptable in the Hong Kong population.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.subjectChineseen_HK
dc.subjectDown's syndromeen_HK
dc.subjectScreeningen_HK
dc.subjectSecond trimesteren_HK
dc.subject.meshAdulten_US
dc.subject.meshChorionic Gonadotropin - Blooden_US
dc.subject.meshDown Syndrome - Diagnosisen_US
dc.subject.meshFalse Negative Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaternal Ageen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleSecond-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for Down's syndrome in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailTang, LCH: lchtang@hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityTang, LCH=rp01756en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(199806)18:6<585::AID-PD305>3.0.CO;2-Ren_HK
dc.identifier.pmid9664604-
dc.identifier.scopuseid_2-s2.0-0031778653en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031778653&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue6en_HK
dc.identifier.spage585en_HK
dc.identifier.epage589en_HK
dc.identifier.isiWOS:000074568800007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, YH=55665136900en_HK
dc.identifier.scopusauthoridGhosh, A=7403963873en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridTang, LCH=7402081111en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridSin, SY=7006553270en_HK
dc.identifier.scopusauthoridHo, PKH=37044515500en_HK

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