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Article: Second-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian women

TitleSecond-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian women
Authors
KeywordsDown syndrome
Screening
Urinary gonadotrophin peptide (UGP)
Issue Date1997
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1997, v. 17 n. 12, p. 1101-1106 How to Cite?
AbstractMaternal urinary gonadotrophin peptide (UGP) was recently found to be elevated in second-trimester Down syndrome pregnancies. There is controversy about its screening efficacy. Data in the Asian population are scanty. We measured the UGP levels in 29 Down syndrome pregnancies and 297 controls and expressed them as a ratio of the urine creatinine concentration. Median UGP MOM was elevated to 3.44 (95 per cent confidence interval 1.99-5.13) in cases, compared with controls. UGP values were widely scattered in cases and controls with extensive overlap such that only 35 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. The data of the present study and previous reports show that there is a wide variability of gestation-specific UGP median values. UGP alone does not appear to be an effective screening marker for fetal Down syndrome.
Persistent Identifierhttp://hdl.handle.net/10722/180627
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
References

 

DC FieldValueLanguage
dc.contributor.authorLam, YHen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorTang, LCHen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorHo, PKHen_HK
dc.date.accessioned2013-01-28T01:40:45Z-
dc.date.available2013-01-28T01:40:45Z-
dc.date.issued1997en_HK
dc.identifier.citationPrenatal Diagnosis, 1997, v. 17 n. 12, p. 1101-1106en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/180627-
dc.description.abstractMaternal urinary gonadotrophin peptide (UGP) was recently found to be elevated in second-trimester Down syndrome pregnancies. There is controversy about its screening efficacy. Data in the Asian population are scanty. We measured the UGP levels in 29 Down syndrome pregnancies and 297 controls and expressed them as a ratio of the urine creatinine concentration. Median UGP MOM was elevated to 3.44 (95 per cent confidence interval 1.99-5.13) in cases, compared with controls. UGP values were widely scattered in cases and controls with extensive overlap such that only 35 per cent of Down syndrome cases were expected to be detected at a 5 per cent false-positive rate. The data of the present study and previous reports show that there is a wide variability of gestation-specific UGP median values. UGP alone does not appear to be an effective screening marker for fetal Down syndrome.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.subjectDown syndromeen_HK
dc.subjectScreeningen_HK
dc.subjectUrinary gonadotrophin peptide (UGP)en_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBiological Markers - Urineen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Urineen_US
dc.subject.meshDown Syndrome - Diagnosis - Embryology - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Diagnosis - Ethnology - Urineen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshNormal Distributionen_US
dc.subject.meshPeptide Fragments - Urineen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshPrenatal Diagnosis - Methods - Statistics & Numerical Dataen_US
dc.subject.meshProspective Studiesen_US
dc.titleSecond-trimester maternal urinary gonadotrophin peptide screening for fetal Down syndrome in Asian womenen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailTang, LCH: lchtang@hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityTang, LCH=rp01756en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0223(199712)17:12<1101::AID-PD195>3.0.CO;2-Sen_HK
dc.identifier.pmid9467806en_HK
dc.identifier.scopuseid_2-s2.0-0031436013en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031436013&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1101en_HK
dc.identifier.epage1106en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, YH=55665136900en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridTang, LCH=7402081111en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridHo, PKH=37044515500en_HK

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