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Article: Cardiac blood flow studies in fetuses with haemoglobin Bart's disease

TitleCardiac blood flow studies in fetuses with haemoglobin Bart's disease
Authors
Issue Date1994
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1994, v. 14 n. 7, p. 627-632 How to Cite?
AbstractBlood flow across the atrioventricular valves and outflow tracts was measured in 55 normal fetuses and 32 fetuses with haemoglobin (Hb) Bart's disease between 18 and 26 weeks of gestation. The mean velocities remained unchanged in both normal and affected fetuses over the gestations studied. The volume flow across both atrioventricular valves and outflow tracts increased as the gestation advanced in both normal and affected fetuses, but was significantly higher in affected than in normal fetuses. The same magnitude of increased flow was found in both hydropic and non-hydropic fetuses with Hb Bart's disease. These findings suggest that fetuses with severe and long-standing anaemia have a remarkable cardiac compensatory mechanism for the maintenance of tissue oxygenation. In response to anaemia and circulatory loading, the cardiac chambers and outflow tracts enlarge proportionately up to twice the normal values. Because of this response and the operation of the Frank-Starling mechanism, the heart is able to maintain a normal mean velocity of propulsion and the net output is increased to two to three times that in normal fetuses. Hydropic changes in these anaemic fetuses appear unrelated to cardiac failure as cardiac failure is not observed at the time that hydropic changes develop.
Persistent Identifierhttp://hdl.handle.net/10722/180622
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorTang, Men_US
dc.contributor.authorLeung, MPen_US
dc.contributor.authorFung, LMen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2013-01-28T01:40:43Z-
dc.date.available2013-01-28T01:40:43Z-
dc.date.issued1994en_US
dc.identifier.citationPrenatal Diagnosis, 1994, v. 14 n. 7, p. 627-632en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180622-
dc.description.abstractBlood flow across the atrioventricular valves and outflow tracts was measured in 55 normal fetuses and 32 fetuses with haemoglobin (Hb) Bart's disease between 18 and 26 weeks of gestation. The mean velocities remained unchanged in both normal and affected fetuses over the gestations studied. The volume flow across both atrioventricular valves and outflow tracts increased as the gestation advanced in both normal and affected fetuses, but was significantly higher in affected than in normal fetuses. The same magnitude of increased flow was found in both hydropic and non-hydropic fetuses with Hb Bart's disease. These findings suggest that fetuses with severe and long-standing anaemia have a remarkable cardiac compensatory mechanism for the maintenance of tissue oxygenation. In response to anaemia and circulatory loading, the cardiac chambers and outflow tracts enlarge proportionately up to twice the normal values. Because of this response and the operation of the Frank-Starling mechanism, the heart is able to maintain a normal mean velocity of propulsion and the net output is increased to two to three times that in normal fetuses. Hydropic changes in these anaemic fetuses appear unrelated to cardiac failure as cardiac failure is not observed at the time that hydropic changes develop.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshBlood Flow Velocityen_US
dc.subject.meshBlood Volumeen_US
dc.subject.meshCoronary Circulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHeart Valves - Embryologyen_US
dc.subject.meshHemoglobinopathies - Embryology - Physiopathologyen_US
dc.subject.meshHemoglobins, Abnormalen_US
dc.subject.meshHumansen_US
dc.subject.meshPregnancyen_US
dc.titleCardiac blood flow studies in fetuses with haemoglobin Bart's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailTang, M: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, M=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1970140720en_US
dc.identifier.pmid7971764-
dc.identifier.scopuseid_2-s2.0-0028024728en_US
dc.identifier.volume14en_US
dc.identifier.issue7en_US
dc.identifier.spage627en_US
dc.identifier.epage632en_US
dc.identifier.isiWOS:A1994NY25900019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGhosh, A=7403963873en_US
dc.identifier.scopusauthoridTang, M=8943401300en_US
dc.identifier.scopusauthoridLeung, MP=7201944800en_US
dc.identifier.scopusauthoridFung, LM=7101721365en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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