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Article: Justification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defects

TitleJustification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defects
Authors
Issue Date1986
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 1986, v. 6 n. 2, p. 83-87 How to Cite?
AbstractA prospective study of maternal serum alphafetoprotein (α-FP) screening of 9838 women in an area with low prevalence of neural tube defects and predominance of anencephalics revealed that an intervention point of single serum α-FP level above 2·8 times the median was appropriate for this population. Ninety per cent of anencephalics and all fetuses with anterior abdominal wall defects were detected. There was no spina bifida among the population screened. Two per cent of the population screened had serum α-FP level above this cut-off level. Thirty-two per cent of twin pregnancies, 7 per cent of small-for-gestational age infants and 9 per cent of pregnancies which ended in either abortion or perinatal death in the population screened also had one serum α-FP level above this intervention point. The false positive rate was 66 per cent. This false positive rate was only reduced to 63 per cent if insted of one, two serum α-FP level above this intervention point was considered abnormal. Using this strategy there was no significant reduction in the detection rate of fetal anomalies and other pregnancy complications. Because of the predominance of anencephalics in this population the diagnosis of fetas anomaly in women with abnormal serum α-FP level was made by ultrasound examination alone. The reason amniocentesis was not performed in these patients was to avoid unnecessary loss of normal pregnancies which may result from this procedure.
Persistent Identifierhttp://hdl.handle.net/10722/180615
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorTang, MHYen_US
dc.contributor.authorTai, Den_US
dc.contributor.authorNie, Gen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2013-01-28T01:40:40Z-
dc.date.available2013-01-28T01:40:40Z-
dc.date.issued1986en_US
dc.identifier.citationPrenatal Diagnosis, 1986, v. 6 n. 2, p. 83-87en_US
dc.identifier.issn0197-3851en_US
dc.identifier.urihttp://hdl.handle.net/10722/180615-
dc.description.abstractA prospective study of maternal serum alphafetoprotein (α-FP) screening of 9838 women in an area with low prevalence of neural tube defects and predominance of anencephalics revealed that an intervention point of single serum α-FP level above 2·8 times the median was appropriate for this population. Ninety per cent of anencephalics and all fetuses with anterior abdominal wall defects were detected. There was no spina bifida among the population screened. Two per cent of the population screened had serum α-FP level above this cut-off level. Thirty-two per cent of twin pregnancies, 7 per cent of small-for-gestational age infants and 9 per cent of pregnancies which ended in either abortion or perinatal death in the population screened also had one serum α-FP level above this intervention point. The false positive rate was 66 per cent. This false positive rate was only reduced to 63 per cent if insted of one, two serum α-FP level above this intervention point was considered abnormal. Using this strategy there was no significant reduction in the detection rate of fetal anomalies and other pregnancy complications. Because of the predominance of anencephalics in this population the diagnosis of fetas anomaly in women with abnormal serum α-FP level was made by ultrasound examination alone. The reason amniocentesis was not performed in these patients was to avoid unnecessary loss of normal pregnancies which may result from this procedure.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_US
dc.relation.ispartofPrenatal Diagnosisen_US
dc.subject.meshAnencephaly - Diagnosisen_US
dc.subject.meshFalse Positive Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshNeural Tube Defects - Diagnosisen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Trimester, Seconden_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshAlpha-Fetoproteins - Analysisen_US
dc.titleJustification of maternal serum alphafetoprotein screening in a population with low incidence of neural tube defectsen_US
dc.typeArticleen_US
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_US
dc.identifier.authorityTang, MHY=rp01701en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1970060202-
dc.identifier.pmid2422642-
dc.identifier.scopuseid_2-s2.0-0022591994en_US
dc.identifier.volume6en_US
dc.identifier.issue2en_US
dc.identifier.spage83en_US
dc.identifier.epage87en_US
dc.identifier.isiWOS:A1986A786600001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridGhosh, A=7403963873en_US
dc.identifier.scopusauthoridTang, MHY=8943401300en_US
dc.identifier.scopusauthoridTai, D=35863000800en_US
dc.identifier.scopusauthoridNie, G=55528515600en_US
dc.identifier.scopusauthoridMa, HK=36986403800en_US

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