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Article: Predictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy

TitlePredictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapy
Authors
KeywordsCranial Nerve Palsy
Nasopharyngeal Carcinoma
Radiotherapy
Issue Date2013
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2013, v. 49 n. 1, p. 49-54 How to Cite?
AbstractObjectives: To identify the key predictive factors of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma (NPC). Method and materials: From November 1998 to December 2007, all consecutive patients with newly diagnosed NPC who were curatively treated with radiotherapy and subsequently developed radiation-induced cranial nerve palsy (RICNP) were included in our study. Patients with cranial nerve palsy due to disease recurrence were excluded. Their records were retrospectively reviewed. Results: Amongst 965 patients with NPC treated with radical radiotherapy, 41 developed new cranial nerve palsy. After exclusion of 5 patients with cranial nerve palsy due to recurrence, 36 (3.7%) developed RICNP. The median follow-up was 8.9 years (range, 3.2-11.3 years). Ten of the 36 patients had cranial nerve palsy at presentation. Twenty-seven patients had single cranial nerve palsy and 9 patients had multiple cranial nerve palsy. The most commonly involved cranial nerve was cranial nerve XII, with 30 patients having palsy of cranial nerve XII and 6 of them having bilateral cranial nerve XII palsies. Magnetic resonance imaging features of radiation-induced hypoglossal nerve palsy were demonstrated in our study. Multivariate analysis revealed that cranial nerve palsy at presentation was an independent prognostic factor for the development of RICNP. Other factors including T staging, N staging, gender, age, radiotherapy technique and the use of chemotherapy have no significant relationship with the risk of developing RICNP. Conclusion: RICNP in patients with NPC is not a rare complication, and cranial nerve palsy at presentation is an important prognostic factor. © 2012 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/180454
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuk, YSen_US
dc.contributor.authorShum, JSFen_US
dc.contributor.authorSze, HCKen_US
dc.contributor.authorChan, LLKen_US
dc.contributor.authorNg, WTen_US
dc.contributor.authorLee, AWMen_US
dc.date.accessioned2013-01-28T01:38:15Z-
dc.date.available2013-01-28T01:38:15Z-
dc.date.issued2013en_US
dc.identifier.citationOral Oncology, 2013, v. 49 n. 1, p. 49-54en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttp://hdl.handle.net/10722/180454-
dc.description.abstractObjectives: To identify the key predictive factors of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma (NPC). Method and materials: From November 1998 to December 2007, all consecutive patients with newly diagnosed NPC who were curatively treated with radiotherapy and subsequently developed radiation-induced cranial nerve palsy (RICNP) were included in our study. Patients with cranial nerve palsy due to disease recurrence were excluded. Their records were retrospectively reviewed. Results: Amongst 965 patients with NPC treated with radical radiotherapy, 41 developed new cranial nerve palsy. After exclusion of 5 patients with cranial nerve palsy due to recurrence, 36 (3.7%) developed RICNP. The median follow-up was 8.9 years (range, 3.2-11.3 years). Ten of the 36 patients had cranial nerve palsy at presentation. Twenty-seven patients had single cranial nerve palsy and 9 patients had multiple cranial nerve palsy. The most commonly involved cranial nerve was cranial nerve XII, with 30 patients having palsy of cranial nerve XII and 6 of them having bilateral cranial nerve XII palsies. Magnetic resonance imaging features of radiation-induced hypoglossal nerve palsy were demonstrated in our study. Multivariate analysis revealed that cranial nerve palsy at presentation was an independent prognostic factor for the development of RICNP. Other factors including T staging, N staging, gender, age, radiotherapy technique and the use of chemotherapy have no significant relationship with the risk of developing RICNP. Conclusion: RICNP in patients with NPC is not a rare complication, and cranial nerve palsy at presentation is an important prognostic factor. © 2012 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_US
dc.relation.ispartofOral Oncologyen_US
dc.subjectCranial Nerve Palsyen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectRadiotherapyen_US
dc.titlePredictive factors and radiological features of radiation-induced cranial nerve palsy in patients with nasopharyngeal carcinoma following radical radiotherapyen_US
dc.typeArticleen_US
dc.identifier.emailSze, HCK: henrysze@graduate.hku.hken_US
dc.identifier.authoritySze, HCK=rp01697en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.oraloncology.2012.07.011en_US
dc.identifier.pmid22892236-
dc.identifier.scopuseid_2-s2.0-84871461356en_US
dc.identifier.hkuros219063-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84871461356&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue1en_US
dc.identifier.spage49en_US
dc.identifier.epage54en_US
dc.identifier.isiWOS:000312832200010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLuk, YS=36646421700en_US
dc.identifier.scopusauthoridShum, JSF=55535126000en_US
dc.identifier.scopusauthoridSze, HCK=23490726900en_US
dc.identifier.scopusauthoridChan, LLK=47461072500en_US
dc.identifier.scopusauthoridNg, WT=14825781500en_US
dc.identifier.scopusauthoridLee, AWM=55534836100en_US

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