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Conference Paper: Clinical characteristics and outcome of pediatric and adolescent patients with follicular lymphoma - The EICNHL and i-BFM study groups experience

TitleClinical characteristics and outcome of pediatric and adolescent patients with follicular lymphoma - The EICNHL and i-BFM study groups experience
Authors
KeywordsMedical sciences
Hematology
Issue Date2012
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
The 4th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma, New York, NY., 1-3 November 2012. In British Journal of Haematology, 2012, v. 159 suppl. S1, p. 10, abstract no. 17 How to Cite?
AbstractBACKGROUND: Follicular lymphoma (FL) rarely occurs in children and adolescents accounting for 2% of all B-cell non-Hodgkin’s lymphomas. Moreover, comprehensive data on clinical, histopathologic and outcome characteristics are scarce. OBJECTIVES/METHODS: The aim of this multinational retrospective study including 13 EICNHL and/or i-BFM study group members was to assess these parameters in a series of 63 patients with FL. RESULTS: The male to female ratio was 3:1 and median age was 13 years. Thirty-six suffered from stage I, 19 from stage II, six from stage III and two from stage IV disease. Median serum LDH level was 252 U/l. Ten percent demonstrated grade I/II and 66% grade III histopathology (not available in 24%). Seventy-nine percent had peripheral lymph node involvement. Of 36 stage I patients 30 had a complete resection. Of all 63 patients 44 received any chemotherapy and one rituximab only while 17 underwent a watch and wait strategy. Only one patient relapsed; 4-year pEFS was 94 ± 5%, overall survival 100% after a median follow-up of 2.2 years. CONCLUSIONS: FL in children and adolescents seems to be associated with male gender, >10 years of age, limited stage of disease, low LDH levels and peripheral lymph node involvement. Treatment outcome is excellent.
DescriptionThis journal suppl. is Special Issue: 4rth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma ... 2012
Persistent Identifierhttp://hdl.handle.net/10722/180304
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313

 

DC FieldValueLanguage
dc.contributor.authorMann, Gen_US
dc.contributor.authorRosolen, Aen_US
dc.contributor.authorHoribe, Ken_US
dc.contributor.authorUyttebroeck, Aen_US
dc.contributor.authorBeishuizen, Aen_US
dc.contributor.authorNiggli, Fen_US
dc.contributor.authorCsoka, Men_US
dc.contributor.authorKrenova, Zen_US
dc.contributor.authorMelgren, Ken_US
dc.contributor.authorKabickova, Een_US
dc.contributor.authorChiang, Aen_US
dc.contributor.authorReiter, Aen_US
dc.contributor.authorWilliams, Den_US
dc.contributor.authorBurkhardt, Ben_US
dc.date.accessioned2013-01-21T01:35:31Z-
dc.date.available2013-01-21T01:35:31Z-
dc.date.issued2012en_US
dc.identifier.citationThe 4th International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma, New York, NY., 1-3 November 2012. In British Journal of Haematology, 2012, v. 159 suppl. S1, p. 10, abstract no. 17en_US
dc.identifier.issn0007-1048-
dc.identifier.urihttp://hdl.handle.net/10722/180304-
dc.descriptionThis journal suppl. is Special Issue: 4rth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin's Lymphoma ... 2012-
dc.description.abstractBACKGROUND: Follicular lymphoma (FL) rarely occurs in children and adolescents accounting for 2% of all B-cell non-Hodgkin’s lymphomas. Moreover, comprehensive data on clinical, histopathologic and outcome characteristics are scarce. OBJECTIVES/METHODS: The aim of this multinational retrospective study including 13 EICNHL and/or i-BFM study group members was to assess these parameters in a series of 63 patients with FL. RESULTS: The male to female ratio was 3:1 and median age was 13 years. Thirty-six suffered from stage I, 19 from stage II, six from stage III and two from stage IV disease. Median serum LDH level was 252 U/l. Ten percent demonstrated grade I/II and 66% grade III histopathology (not available in 24%). Seventy-nine percent had peripheral lymph node involvement. Of 36 stage I patients 30 had a complete resection. Of all 63 patients 44 received any chemotherapy and one rituximab only while 17 underwent a watch and wait strategy. Only one patient relapsed; 4-year pEFS was 94 ± 5%, overall survival 100% after a median follow-up of 2.2 years. CONCLUSIONS: FL in children and adolescents seems to be associated with male gender, >10 years of age, limited stage of disease, low LDH levels and peripheral lymph node involvement. Treatment outcome is excellent.-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH-
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectMedical sciences-
dc.subjectHematology-
dc.titleClinical characteristics and outcome of pediatric and adolescent patients with follicular lymphoma - The EICNHL and i-BFM study groups experienceen_US
dc.typeConference_Paperen_US
dc.identifier.emailChiang, A: chiangak@hku.hken_US
dc.identifier.authorityChiang, A=rp00403en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-2141.2012.12053.x-
dc.identifier.hkuros213046en_US
dc.identifier.volume159-
dc.identifier.issuesuppl. S1-
dc.identifier.spage10-
dc.identifier.epage10-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablesml 140226-

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