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Article: A breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depression

TitleA breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depression
Authors
KeywordsActin
Cytoskeleton
Depression
Microtubule
Post-translational modification
Tubulin
Issue Date2013
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr
Citation
Ageing Research Reviews, 2013, v. 12 n. 1, p. 67-75 How to Cite?
AbstractDepression is one of the most common psychiatric disorders with inadequately understood disease mechanisms. It has long been considered that dendritic regression and decrease in the number of dendritic spines are involved in depression. Dendrites made up of microtubules and actin filaments form synapses with neighboring neurons, which come together as an important communication network. Cytoskeletal proteins undergo post-translational modifications to define their structure and function. In depression and other psychiatric disorders, post-translational modifications may be disrupted that can result in altered cytoskeletal functions. The disruption of microtubule and actin in terms of morphology and functions may be a leading cause of dendritic regression and decrease in dendritic spine in depression.
Persistent Identifierhttp://hdl.handle.net/10722/180126
ISSN
2015 Impact Factor: 7.526
2015 SCImago Journal Rankings: 3.289
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, GTHen_US
dc.contributor.authorChang, RCCen_US
dc.contributor.authorLaw, ACKen_US
dc.date.accessioned2013-01-21T01:29:12Z-
dc.date.available2013-01-21T01:29:12Z-
dc.date.issued2013en_US
dc.identifier.citationAgeing Research Reviews, 2013, v. 12 n. 1, p. 67-75en_US
dc.identifier.issn1568-1637-
dc.identifier.urihttp://hdl.handle.net/10722/180126-
dc.description.abstractDepression is one of the most common psychiatric disorders with inadequately understood disease mechanisms. It has long been considered that dendritic regression and decrease in the number of dendritic spines are involved in depression. Dendrites made up of microtubules and actin filaments form synapses with neighboring neurons, which come together as an important communication network. Cytoskeletal proteins undergo post-translational modifications to define their structure and function. In depression and other psychiatric disorders, post-translational modifications may be disrupted that can result in altered cytoskeletal functions. The disruption of microtubule and actin in terms of morphology and functions may be a leading cause of dendritic regression and decrease in dendritic spine in depression.-
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr-
dc.relation.ispartofAgeing Research Reviewsen_US
dc.subjectActin-
dc.subjectCytoskeleton-
dc.subjectDepression-
dc.subjectMicrotubule-
dc.subjectPost-translational modification-
dc.subjectTubulin-
dc.titleA breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depressionen_US
dc.typeArticleen_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.emailLaw, ACK: acklaw@hku.hken_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.authorityLaw, ACK=rp00262en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.arr.2012.08.004-
dc.identifier.pmid22995339-
dc.identifier.scopuseid_2-s2.0-84867456287-
dc.identifier.hkuros212921en_US
dc.identifier.volume12en_US
dc.identifier.issue1-
dc.identifier.spage67en_US
dc.identifier.epage75en_US
dc.identifier.isiWOS:000315125800008-
dc.publisher.placeIreland-

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