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Conference Paper: Computational identification of reassortments in avian influenza viruses

TitleComputational identification of reassortments in avian influenza viruses
Authors
Issue Date2007
PublisherAmerican Association of Avian Pathologists, Inc. The Journal's web site is located at http://avdi.allenpress.com/avdionline/?request=index-html
Citation
Avian Diseases, 2007, v. 51 SUPPL. 1, p. 434-439 How to Cite?
AbstractThe avian influenza virus (AIV) has eight genomic segments (hemagglutinin [HA], neuraminidase [NA], RNA polymerase subunit A [PA], RNA polymerase subunit B1 [PB1], RNA polymerase subunit B2 [PB2], nucleoprotein [NP], nonstructural gene [NS], and matrix protein [M]). The genetic reassortments, recombinations, and mutations lead to a rapid emergence of novel genotypes of the AIVs during their evolution. These emerging viruses provide a large reservoir for pandemic strains. Here we describe a novel computational strategy for genetic reassortment identification. In contrast to the traditional phylogenetic approaches, our method views the genotypes through the modules in networks. Genetic segments with short phylogenetic distance are grouped into modules. Our method is not limited to the number of sequences. We applied this method in reassortment identification of NP segments in H5N1 AIVs. We identified two new potential reassortments for H5N, AIVs beyond the reported genotypes in literature.
Persistent Identifierhttp://hdl.handle.net/10722/179847
ISSN
2015 Impact Factor: 1.104
2015 SCImago Journal Rankings: 0.772
References

 

DC FieldValueLanguage
dc.contributor.authorWan, XFen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorLin, Gen_US
dc.contributor.authorHolton, SBen_US
dc.contributor.authorDesmone, RAen_US
dc.contributor.authorShyu, CRen_US
dc.contributor.authorGuan, Yen_US
dc.contributor.authorEmch, MEen_US
dc.date.accessioned2012-12-19T10:06:04Z-
dc.date.available2012-12-19T10:06:04Z-
dc.date.issued2007en_US
dc.identifier.citationAvian Diseases, 2007, v. 51 SUPPL. 1, p. 434-439en_US
dc.identifier.issn0005-2086en_US
dc.identifier.urihttp://hdl.handle.net/10722/179847-
dc.description.abstractThe avian influenza virus (AIV) has eight genomic segments (hemagglutinin [HA], neuraminidase [NA], RNA polymerase subunit A [PA], RNA polymerase subunit B1 [PB1], RNA polymerase subunit B2 [PB2], nucleoprotein [NP], nonstructural gene [NS], and matrix protein [M]). The genetic reassortments, recombinations, and mutations lead to a rapid emergence of novel genotypes of the AIVs during their evolution. These emerging viruses provide a large reservoir for pandemic strains. Here we describe a novel computational strategy for genetic reassortment identification. In contrast to the traditional phylogenetic approaches, our method views the genotypes through the modules in networks. Genetic segments with short phylogenetic distance are grouped into modules. Our method is not limited to the number of sequences. We applied this method in reassortment identification of NP segments in H5N1 AIVs. We identified two new potential reassortments for H5N, AIVs beyond the reported genotypes in literature.en_US
dc.languageengen_US
dc.publisherAmerican Association of Avian Pathologists, Inc. The Journal's web site is located at http://avdi.allenpress.com/avdionline/?request=index-htmlen_US
dc.relation.ispartofAvian Diseasesen_US
dc.subject.meshAlgorithmsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBirds - Virologyen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshGenotypeen_US
dc.subject.meshInfluenza A Virus, H5n1 Subtype - Geneticsen_US
dc.subject.meshInfluenza In Birds - Virologyen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshReassortant Viruses - Geneticsen_US
dc.subject.meshSoftwareen_US
dc.subject.meshViral Proteins - Geneticsen_US
dc.titleComputational identification of reassortments in avian influenza virusesen_US
dc.typeConference_Paperen_US
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, Y=rp00397en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17494602-
dc.identifier.scopuseid_2-s2.0-34247574837en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247574837&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spage434en_US
dc.identifier.epage439en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWan, XF=9335365800en_US
dc.identifier.scopusauthoridWu, X=14623363500en_US
dc.identifier.scopusauthoridLin, G=7401699810en_US
dc.identifier.scopusauthoridHolton, SB=16245464200en_US
dc.identifier.scopusauthoridDesmone, RA=16244632800en_US
dc.identifier.scopusauthoridShyu, CR=7005681170en_US
dc.identifier.scopusauthoridGuan, Y=7202924055en_US
dc.identifier.scopusauthoridEmch, ME=6603096379en_US

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